News
Le Centre de Biologie Structurale (CBS) de Montpellier s’engage à accueillir 6 stagiaires de seconde générale et technologique, du 17 au 28 juin 2024
Created on 07/03/2024
STAGES de SECONDE
Le Centre de Biologie Structurale (CBS) de Montpellier s’engage à accueillir 6 stagiaires de seconde générale et technologique, du ...
The “Impulscience” prize awarded to Ashley Nord
Created on 22/11/2023
The Impulscience® program aims to reward and support excellent researchers in France, and to strengthen the attractiveness of France as a place of res...
Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria
Created on 05/10/2023
Overlay of Myxococcus xanthus bacteria trajectories
during the invasion of an Escherichia coli colony.
Publication link: Rombouts, S., Ma...
Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction
Created on 08/09/2023
Link to publication: https://www.sciencedirect.com/science/article/abs/pii/S0969212623002897?dgcid=author
The signaling pathways of arre...
Combining mechanical and superresolution measurements to reveal the plasticity of the Nuclear Pore Complexes
Created on 29/03/2023
Nuclear pore complexes (NPCs) are the only gateways between the nucleus and cytoplasm in eukaryotic cells, facilitating the transport of selec...
The structure of pathogenic huntingtin exon-1 defines the bases of its aggregation propensity
Created on 10/03/2023
Link to publication: https://www.nature.com/articles/s41594-023-00920-0
Huntington’s Disease (HD) is a deadly neurodegenerative disorder caused by an...
Structure of the dioxin receptor (AHR) revealed by cryo-electron microscopy
Created on 22/11/2022
Living organisms have evolved protein sensors that help them adapt to their environment. The aromatic hydrocarbon receptor (AHR) is an emblematic memb...
Get out of here, let me get on it ! The G protein and the beta-arrestiin
Created on 10/10/2022
Arginine-vasopressin (AVP) is known as the antidiuretic hormone, and it regulates a vital function of our body: water homeostasis. It plays a role in ...
Original structure and regulation by acetylation of human NADK2
Created on 30/09/2022
NAD+ kinases (NADKs) are metabolite kinases that phosphorylate NAD+ molecules to make NADP+, a limiting substrate for the generation of reducing power...
DNA origami to explore cell mechanotransduction
Created on 01/09/2022
How cells respond to mechanical forces by converting them into biological signals underlie crucial cellular processes. Our understanding of mechanotra...
The C-terminal domains of GPCR are disordered with transient secondary structures
Created on 05/07/2022
Arrestin-dependent pathways are a central component of G protein-coupled receptor (GPCR) signaling. This pathway is activated after the phosphorylatio...
Dynamic stiffening of the flagellar hook
Created on 13/06/2022
For many bacteria, motility stems from one or more flagella, each rotated by the bacterial flagellar motor, a powerful rotary molecular machine. The h...
Cryo-EM structure of the V2R:AVP:Gs complex
Created on 11/06/2021
The cryo-EM structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex
Arginine-vasopressin (AVP) is known as...
Phd Postdoc Day - 2021 July 5th
Created on 08/06/2021
The first CBS PhD/postdoc meeting will be held on Monday, the 5th of July via Zoom ! This day will gather all non-permanent young researchers from the...
Quantifying ribosome traffic from profiling data
Created on 28/01/2021
A non-equilibrium analysis model was developed for inferring the relative rates of translation initiation and elongation rates from ribosome profiling...
Programming history-dependent logic in cellular populations
Created on 26/01/2021
Genetic programs operating in a history-dependent fashion are ubiquitous in nature and govern sophisticated processes such as development and differen...
How chemical pollutants can become more harmful when combined
Created on 25/01/2021
So-called endocrine disruptors — environmental pollutants that can cause reproductive, metabolic, or neurological disorders — target the pregnane X re...
Speech can propagate pathogens
Created on 09/10/2020
Speech is a potent route for viral transmission in the COVID-19 pandemic. Informed mitigation strategies are difficult to develop since no aerosolizat...
Important implication of intrinsically disordered protein in signaling pathways
Created on 17/07/2020
Cellular signaling machinery is involved in major physiological processes and therefore in a large number of diseases. However, full understanding of ...
ATP-driven separation of liquid phase condensates in bacteria
Created on 15/07/2020
Liquid-liquid phase separated (LLPS) states are key to compartmentalise components in the absence of membranes, however it is unclear whether LLPS con...
Study on cis-regulatory chromatin loops
Created on 08/07/2020
Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during development
Sergio Martin Espinola, Mar...
Transcription and chromosome observation in single cells with Hi-M
Created on 08/07/2020
Direct and simultaneous observation of transcription and chromosome architecture in single cells with Hi-M
Andrés M. Cardozo Gizzi, Sergio M. Espinol...
Engineering ‘Plug-and-Play’ Cell-Free Biosensors
Created on 07/07/2020
Cell-free protein synthesis represents a promising avenue for developing next-generation diagnostics. Researchers at the Center for Structural Biology...
Absence of proline cis-conformation in poly-proline tracts
Created on 02/07/2020
The study of prolines within proteins has been traditionally a challenge, especially in repetitions (poly-proline). By combining site-specific isotopi...
COVID generation: workshop in an elementary school
Created on 01/07/2020
What is a microbe? What are the differences between a bacteria and a virus? How does soap protect against viruses? Animated debates, experiences ... C...
High-Res Photonic Force Microscopy Based on Sharp Nanofabricated Tips
Created on 26/06/2020
The photonic force microscope (PhFM) is better suited than the atomic force microscope (AFM) to the observation of soft tissues, in particular biologi...
CBS Lifetime Seminar Series
Created on 23/09/2019
This year, the Centre of Structural Biochemistry is organizing a series of seminars on topics related to the LifeTime Initiative.
If you want to meet...
Le CBS participe à la Fête de la Science
Created on 08/09/2019
Le Cente de Biochimie Structurale ouvre ses portes et organise plusieurs évenements pour fêter les 80 an...
Mechanism of host-pathogen recognition
Created on 12/11/2018
Rice, like other plants, has immune receptors represented largely by the family of NLR proteins. Some of these proteins have an integrated decoy domai...
A new mecanism for transcription initiation in M. Tuberculosis
Created on 28/05/2018
In bacteria, the sigma subunit of RNA polymerase controls promoter recognition and initiation of RNA synthesis. Using Förster energy transfer between ...
Une nouvelle méthode ouvre la voie à l’étude des protéines à séquence répétée
Created on 24/04/2018
Certaines pathologies – c'est notamment le cas de la maladie de Huntington - sont causées par des protéines présentant un nombre anormalement élevé de...
25th anniversary of the CBS
Created on 20/03/2018
The CBS organizes a special event to celebrate its twenty-fifth anniversary on May 24 and 25, 2018. The research that has been conducted there for 25 ...
Teaching bacteria to recognize new molecules
Created on 20/03/2018
Microbes can be engineered for different applications in our daily life, such as microbiome therapeutics, diagnosis of disease, or environmental monit...
Biochemical approach to understand Huntington's disease and poly-glutamine-related pathologies
Created on 05/03/2018
Huntington's Disease (HD) is a hereditary neurodegenerative disorder that is characterized by involuntary movements, general motor impairment, psychia...
Rare yet specific interactions shape the 3D folding of chromatin
Created on 16/01/2018
The organization of DNA in the three-dimensional space of the cell nucleus determines the regulation of most cellular activities. In recent years, a n...
Catch-bond and mechanosensing of the bacterial flagellar motor
Created on 11/12/2017
The bacterial flagellar motor (BFM) is the rotary motor that rotates each bacterial flagellum, powering the swimming and swarming of many motile bacte...
Impact of fluorescent protein fusions on the bacterial flagellar motor
Created on 02/11/2017
Fluorescent fusion proteins open a direct and unique window onto protein function. However, they also introduce the risk of perturbation of the functi...
3D supramolecular assemblies from 2D super-resolution microscopy images
Created on 05/10/2017
HOW TO GET 3D RECONSTRUCTION OF SUPRAMOLECULAR ASSEMBLIES FROM 2D SUPER-RESOLUTION LIGHT MICROSCOPY IMAGES?
Super-resolution microscopies ena...
Monitoring protein folding through high pressure NMR spectroscopy
Created on 14/06/2017
Everything you always wanted to know on the use of High-Pressure NMR to study Protein Folding (but were afraid to ask).
"Monitoring protein f...
Host-pathogen recognition by the integrated decoy model
Created on 19/01/2017
NLR multidomain proteins largely mediate the immune response in plants. These immune receptors are the key elements in the recognition of the pathogen...
Unravelling bacterial motility
Created on 20/10/2016
During its evolution, the gram-negative bacteria Myxococcus xanthus has developed an original property : the ability to move on surfaces in the absenc...
DNA segregation super-resolved
Created on 19/10/2016
To ensure proper growth, bacterial genome must be faithfully segregated so that each daughter cell, resulting from cellular division, inherits an iden...
Vanessa Delfosse receives the "Grandes avancées françaises en biologie" prize
Created on 28/04/2016
The french Academy of sciences rewards young researchers for their contribution to major scientific advances in biology.
Links:
Video Académie des S...
Tournants et bifurcations, acteurs de la vasoocclusion drépanocytaire?
Created on 21/10/2015
La drépanocytose affecte plus de 50 millions de personnes dans le monde et se caractérise par des crises douloureuses de vasoocclusion dont la lo...
Insights into the "cocktail effect" of endocrine disruptors
Created on 07/09/2015
Chemicals which taken in isolation are safe for humans may become harmful when mixed . The team of William Bourguet in Structural Biochemistry Center ...
New Structure of a Protein Modulating Bacterial Gene Silencing
Created on 02/09/2015
Antibiotic resistance and the appearance of new virulent bacterial strains constitute a major threat to human health. The problem is aggravated by the...
Activation Mechanism of the Morphine Receptor Revealed
Created on 31/08/2015
A close collaboration between the team of Sebastien Granier (IGF) in Montpellier, Hélène Déméné (CBS, team "NMR, Structure, Dynamics and Function of B...
Programming bacteria to detect disease
Created on 28/05/2015
Bacteria have a bad reputation and are often seen as enemies causing many diseases such as tuberculosis and cholera. However, bacteria can also be our...
Variable Effect of Kinase Inhibitors on Breast Cancer Cell Lines
Created on 21/04/2015
Breast tumors belonging to the triple negative subgroup (TN) (no estrogen, no progesterone and no ERBB2 receptors expressed) are the most aggressive a...
Two CBS students receive prizes for youg researchers
Created on 01/04/2015
Congratulations to Patrice Rassam (PhD student 2008-2012 in the team of P.E. Milhiet) who has just been selected to receive the "Prix du Jeune Cherche...