Nuclear Receptors as Integrators of Endogenous and Environmental Signals


Team leader William Bourguet

Team5 small 

Nuclear receptors are master regulators of gene expression in humans. Their biological functions depend on their ability to bind other molecules such as ligands (hormones, vitamins, etc.), DNA and coregulatory proteins. They are also the primary targets of many environmental endocrine disruptors that mimic the action of endogenous ligands and cause a wide range of diseases. A major interest of the group is to reach a detailed understanding of the mechanisms involved in the (de)regulation of nuclear receptor signaling.