The French Infrastructure for Integrated Structural Biology (FRISBI) provides an infrastructure for integrative structural biology approaches, from the molecular to the cellular level, integrating multi-resolution data from X-ray crystallography, small angle X-ray scattering, NMR, Cryo-EM and functional data including development for protein expression and crystallization. FRISBI is open to structural and molecular and cell biologists from both academia and industry from France and Europe.
France‐BioImaging is a large‐scale national research infrastructure. France-Bioimaging will deploy a distributed biological imaging infrastructure in a coordinated and harmonized manner. At the frontier between molecular and cell biology, biophysics and engineering, mathematics and bioinformatics, France-BioImaging gathers, several outstanding biological Imaging Centerssupported by state of the art R&D teams with the aim to cover recent advances in microscopy, spectroscopy, probe engineering and signal processing. Thereby France-BioImaging will provide quantitative measurements, computational analysis and an integrative understanding of a wide range of cellular and tissular activities.
France-BioImaging is a highly pluridisciplinary project with participants in Biology, Physics, Chemistry, Computer science and engineering. The strength of the France-BioImaging consortium is to put efforts together to overcome technological barriers persisting at different levels of Cellular Imaging. Different solutions for each challenge are proposed among different nodes, justifying a second level of France BioImaging organization as shared technological and methodological Work Packages.
More information on the France BioImaging website
By ministerial decision of May 8, 2018, ChemBioFrance is created and registered on the national roadmap of research infrastructures. ChemBioFrance gathers four different ressources and networks: the national chemical library, a network of screening platforms, a distributed chemoinformatics platform, a network of ADME platforms.
Its management is entrusted to the Institute of Chemistry (INC) of the Centre National de la Recherche Scientifique (CNRS), which delegates management to a Research Federation: ChemBioFrance.
It offers « smart »chemical libraries with high potential for bioactivity, partnership with chemists for medicinal chemistry, drug screening services, tools for data analysis and data mining in chemical collections, ADME and toxicology services for the characterization and development of new biologically active molecules.
Its activities include :
- Conception and analyzing of chemical library for screening.
- Analyzing of screening gross data.
- Virtual screening (similarity 2D and 3D, pharmaceutical library, docking).
- Biological profiling of molecules (target prediction).
- Calcul/ Prediction of physicochemical properties (e.g: solubility, logP)
More information on the ChemBioFrance website