Structure and function of highly flexible proteins

Presentation

Team leaders: Pau Bernadó & Nathalie Sibille

 

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Members of the Team:

Researchers

  • Pau Bernadó, INSERM
  • Nathalie Sibille, CNRS

Engineers and technicians

  • Frédéric Allemand, CNRS
  • Aurélie Fournet, INSERM

Non-permanent

  • Annika Urbanek, Post-doc ERC
  • Lucile Sénicourt, Post-doc Labex
  • Amin Sagar, Post-doc Labex
  • Carlos Elena-Real, Post-doc ERC
  • Assia Mouhand, Post-doc ANR
  • Alejandro Estaña, PhD ERC
  • Myriam Guillien, PhD Labex
  • Anna Morató, Engineer ERC

 

Aims of the group: The underlying concept in the structure-function paradigm is that a rigid 3D structure is necessary to perform a biological task. Recent findings have demonstrated that flexibility is crucial for the functioning of biomolecules. Biophysical characterization of highly flexible biomolecules such as IDPs is a challenge for traditional structural biology methods. We propose to address these challenges by integrative approaches where structural and dynamic information derived from different structural biology methods will be integrated into computational tools to achieve more complete models that can provide direct functional insights. The two principal techniques we use are NMR and SAXS. High magnetic fields (>700 MHz) are mandatory to address the challenges posed by IDPs. This line of research will be led by PB and NS that will address two biological systems.

 

Areas of Expertise: Nuclear Magnetic Resonance, Small-Angle X-ray Scattering, Intrinsically Disordered Proteins, Residual Dipolar Couplings, Structural Modelling.


Funding:

- ANR GPCteR (2018-2022)

- ERC-CoG (2015-2020)

- Labex – EpiGenMed

- FRM – Postdoc grant (2016-2017)

- SUDOE-NEUROMED (2014-2015)

- ATIP-AVENIR (2012-2015)

- SPIN-HD: ANR-CHEX-2011. (2012-2015)

 
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