Team 1 comprises experienced researchers in structural biology (Biochemistry, NMR, Crystallography and SAXS) in order to address challenging biological questions. The aim of the team is to take advantage of this broad spectrum of complementary skills to study complex biological systems from an interdisciplinary perspective. The capacity to master several structural biology techniques will ensure the proper development of the scientific challenges. The activities of the team in the last years can be divided in two axes : structural biology of infectious diseases, and High-Pressure NMR and protein unfolding. Important achievements have been accomplished and these broad research lines will be continued in the following years in a more interdisciplinary and integrative approaches will be used to reach better structural and dynamic description of the biomolecular systems targeted.