Centre de Biologie Structurale

Actualités

Séminaires

07 Mai

Conseil Labo 07 Mai 2024 14:00 to 14:30
13 Mai

LLPS Meeting 13 Mai 2024 11:00 to 12:00
16 Mai

Matthew Baker, University New South Wales, Sydney 16 Mai 2024 11:00 to 12:00
CBS invited talk Host: Ashley Nord

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Dernières publications

1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM
Mouhand A, Nakatani K, Kono F, Hippo Y, Matsuo T, Barthe P, Peters J, Suenaga Y, Tamada T, Roumestand C, Biomol NMR Assign, 2024
Hi-M: A Multiplex Oligopaint FISH Method to Capture Chromatin Conformations In Situ and Accompanying Open-Source Acquisition Software
Fiche JB, Schaeffer M, Houbron C, Elkhoury Youhanna C, Messina O, Barho F, Nollmann M, Methods Mol Biol, 2024
Emergence of slip-ideal-slip behavior in tip-links serve as force filters of sound in hearing
Arora N, Hazra JP, Roy S, Bhati GK, Gupta S, Yogendran KP, Chaudhuri A, Sagar A, Rakshit S, Nat Commun, 2024
Increases in cyclin A/Cdk activity and in PP2A-B55 inhibition by FAM122A are key mitosis-inducing events
Lacroix B, Vigneron S, Labbe JC, Pintard L, Lionne C, Labesse G, Castro A, Lorca T, EMBO J, 2024
pyHiM: a new open-source, multi-platform software package for spatial genomics based on multiplexed DNA-FISH imaging
Devos X, Fiche JB, Bardou M, Messina O, Houbron C, Gurgo J, Schaeffer M, Goetz M, Walter T, Mueller F, Nollmann M, Genome Biol, 2024
LactoSpanks: A Collection of IPTG Inducible Promoters for the Commensal Lactic Acid Bacteria Lactobacillus gasseri
Fristot E, Cambray G, Bonnet J, ACS Synth Biol, 2024
PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins
Ghafouri H, Lazar T, Del Conte A, Tenorio Ku LG, Tompa P, Tosatto SCE, Monzon AM, Aspromonte MC, Bernado P, Chaves-Arquero B, Chemes LB, Clementel D, Cordeiro TN, Elena-Real CA, Feig M, Felli IC, Ferrari C, Forman-Kay JD, Gomes T, Gondelaud F, Gradinaru CC, Ha-Duong T, Head-Gordon T, Heidarsson PO, Janson G, Jeschke G, Leonardi E, Liu ZH, Longhi S, Lund XL, Macias MJ, Martin-Malpartida P, Mercadante D, Mouhand A, Nagy G, Nugnes MV, Perez-Canadillas JM, Pesce G, Pierattelli R, Piovesan D, Quaglia F, Ricard-Blum S, Robustelli P, Sagar A, Salladini E, Senicourt L, Sibille N, Teixeira JMC, Tsangaris TE, Varadi M, Nucleic Acids Res, 2024
An innovative in situAFM system for a soft X-ray spectromicroscopy synchrotron beamline
Hafner A, Costa L, Kourousias G, Bonanni V, Zizic M, Stolfa A, Bazi B, Vincze L, Gianoncelli A, Analyst, 2024
Critical micellar concentration determination of pure phospholipids and lipid-raft and their mixtures with cholesterol
Serravalle S, Pisano M, Sciacca MFM, Salamone N, Sicali L, Mazzara G, Costa L, La Rosa C, Proteins, 2024
Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric alphaD pocket
Bancet A, Frem R, Jeanneret F, Mularoni A, Bazelle P, Roelants C, Delcros JG, Guichou JF, Pillet C, Coste I, Renno T, Battail C, Cochet C, Lomberget T, Filhol O, Krimm I, iScience, 2024
Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds
Kwong HS, Paloni M, Grandvuillemin L, Sirounian S, Ancelin A, Lai-Kee-Him J, Grimaldi M, Carivenc C, Lancey C, Ragan TJ, Hesketh EL, Balaguer P, Barducci A, Gruszczyk J, Bourguet W, J Mol Biol, 2023
Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration
Fnaiche A, Chan HC, Paquin A, Gonzalez Suarez N, Vu V, Li F, Allali-Hassani A, Cao MA, Szewczyk MM, Bolotokova A, Allemand F, Gelin M, Barsyte-Lovejoy D, Santhakumar V, Vedadi M, Guichou JF, Annabi B, Gagnon A, ACS Med Chem Lett, 2023
The genome of a bunyavirus cannot be defined at the level of the viral particle but only at the scale of the viral population
Yvon M, German TL, Ullman DE, Dasgupta R, Parker MH, Ben-Mahmoud S, Verdin E, Gognalons P, Ancelin A, Lai Kee Him J, Girard J, Vernerey MS, Fernandez E, Filloux D, Roumagnac P, Bron P, Michalakis Y, Blanc S, Proc Natl Acad Sci U S A, 2023
A single-domain intrabody targeting the follicle-stimulating hormone receptor impacts FSH-induced G protein-dependent signalling
Raynaud P, Jugnarain V, Vaugrente O, Vallet A, Boulo T, Gauthier C, Inoue A, Sibille N, Gauthier C, Jean-Alphonse F, Reiter E, Crepieux P, Bruneau G, FEBS Lett, 2023
Structure-function relationships in protein homorepeats
Elena-Real CA, Mier P, Sibille N, Andrade-Navarro MA, Bernado P, Curr Opin Struct Biol, 2023
3D chromatin interactions involving Drosophila insulators are infrequent but preferential and arise before TADs and transcription
Messina O, Raynal F, Gurgo J, Fiche JB, Pancaldi V, Nollmann M, Nat Commun, 2023
A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation
Valverde JM, Dubra G, Phillips M, Haider A, Elena-Real C, Fournet A, Alghoul E, Chahar D, Andres-Sanchez N, Paloni M, Bernado P, van Mierlo G, Vermeulen M, van den Toorn H, Heck AJR, Constantinou A, Barducci A, Ghosh K, Sibille N, Knipscheer P, Krasinska L, Fisher D, Altelaar M, Nat Commun, 2023
wTSA-CRAFT: an open-access web server for rapid analysis of thermal shift assay experiments
Reys V, Kowalewski J, Gelin M, Lionne C, Bioinform Adv, 2023
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings
Fnaiche A, Melin L, Suarez NG, Paquin A, Vu V, Li F, Allali-Hassani A, Bolotokova A, Allemand F, Gelin M, Cotelle P, Woo S, LaPlante SR, Barsyte-Lovejoy D, Santhakumar V, Vedadi M, Guichou JF, Annabi B, Gagnon A, Bioorg Med Chem Lett, 2023
Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae
Le Naour-Vernet M, Charriat F, Gracy J, Cros-Arteil S, Ravel S, Veillet F, Meusnier I, Padilla A, Kroj T, Cesari S, Gladieux P, PLoS Pathog, 2023
Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria
Rombouts S, Mas A, Le Gall A, Fiche JB, Mignot T, Nollmann M, Nat Commun, 2023
Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction
Guillien M, Mouhand A, Sagar A, Fournet A, Allemand F, Pereira GAN, Thureau A, Bernado P, Baneres JL, Sibille N, Structure, 2023
The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia-reperfusion injury via mitoprotection
Kheyar A, Ahnou N, Ahmed-Belkacem A, Hulin A, Pressiat C, Ghaleh B, Guichou JF, Morin D, Pawlotsky JM, Teixeira-Clerc F, JHEP Rep, 2023
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies
Elena-Real CA, Urbanek A, Imbert L, Morato A, Fournet A, Allemand F, Sibille N, Boisbouvier J, Bernado P, ACS Chem Biol, 2023
Does a Similar 3D Structure Mean a Similar Folding Pathway? The Presence of a C-Terminal alpha-Helical Extension in the 3D Structure of MAX60 Drastically Changes the Folding Pathway Described for Other MAX-Effectors from Magnaporthe oryzae
Lahfa M, Mouhand A, deGuillen K, Barthe P, Kroj T, Padilla A, Roumestand C, Molecules, 2023
Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs
Gedeon A, Ayoub N, Brule S, Raynal B, Karimova G, Gelin M, Mechaly A, Haouz A, Labesse G, Munier-Lehmann H, Protein Sci, 2023
Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins
Malinverni D, Zamuner S, Rebeaud ME, Barducci A, Nillegoda NB, De Los Rios P, Proc Natl Acad Sci U S A, 2023
Isothermal self-assembly of multicomponent and evolutive DNA nanostructures
Rossi-Gendron C, El Fakih F, Bourdon L, Nakazawa K, Finkel J, Triomphe N, Chocron L, Endo M, Sugiyama H, Bellot G, Morel M, Rudiuk S, Baigl D, Nat Nanotechnol, 2023
Structure, dynamics and transferability of the metal-dependent polyhistidine tetramerization motif TetrHis for single-chain Fv antibodies
Healey RD, Couillaud L, Hoh F, Mouhand A, Fouillen A, Couvineau P, Granier S, Leyrat C, Commun Chem, 2023
Linkers in fragment-based drug design: an overview of the literature
Grenier D, Audebert S, Preto J, Guichou JF, Krimm I, Expert Opin Drug Discov, 2023

Voir toutes les publications

Biophysique de la molécule unique

Bienvenue dans le departement de Biophysique des Molécules Uniques du CBS.

Nous developpons et utilisons des methodes biophysiques basées notamment sur l'observation et de manipulation de molécules uniques, afin de comprendre les propriétés des systèmes biologiques. Notre département est organisé en trois groupes de recherche :

SIM-image-241-350

Mécanismes de la ségrégation de l’ADN et du remodelage

Marcelo Nollmann

image2-241-350

Dynamique angulaire au niveau de la molécule unique

Francesco Pedaci

SPT-241-350

Structure et Dynamique d’Assemblages Nucléoprotéiques et Membranaires

Pierre-Emmanuel Milhiet

Emmanuel Margeat

EquipeB-1

EquipeB-2

EquipeB-3

EquipeB-4

EquipeA-6

Les équipes du CBS

Structure, dynamique et fonctions des biomolécules par RMN

Christian Roumestand et Nathalie Declerck
Structure et fonction de protéines hautement flexibles

Pau Bernadó et Nathalie Sibille
Biologie structurale multi-échelles (BSME)

Patrick Bron
Atelier de Biologie-Chimie-Informatique Structurale

Gilles Labesse
Les récepteurs nucléaires, intégrateurs de signaux endogènes et environnementaux

William Bourguet et Albane Le Maire
Modélisation moléculaire multi-échelle

Alessandro Barducci
Mécanismes de la ségrégation de l’ADN et du remodelage

Marcelo Nollmann
Physique et mécanique des systèmes biologiques

Manouk Abkarian et Francesco Pedaci
Biophysique Intégrative des Membranes

Pierre-Emmanuel Milhiet et Emmanuel Margeat
Biologie Synthétique

Jérôme Bonnet et Martin Cohen-Gonsaud
Modélisation moléculaire multi-échelle

Alessandro Barducci
Structure du chromosome et recombinaison en méiose

Thomas Robert
Génomique fonctionnelle et synthétique

Guillaume Cambray
Structure et fonction du récepteur AhR

Jakub Gruszczyk

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