2021
Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
Arsic N, Slatter T, Gadea G, Villain E, Fournet A, Kazantseva M, Allemand F, Sibille N, Seveno M, de Rossi S, Mehta S, Urbach S, Bourdon JC, Bernado P, Kajava AV, Braithwaite A, Roux P, Nat Commun, 2021
Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state
Cao AM, Quast RB, Fatemi F, Rondard P, Pin JP, Margeat E, Nat Commun, 2021
Misic, a general deep learning-based method for the high-throughput cell segmentation of complex bacterial communities
Panigrahi S, Murat D, Le Gall A, Martineau E, Goldlust K, Fiche JB, Rombouts S, Nollmann M, Espinosa L, Mignot T, Elife, 2021
Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors
Sturbaut M, Bailly F, Coevoet M, Sileo P, Pugniere M, Liberelle M, Magnez R, Thuru X, Chartier-Harlin MC, Melnyk P, Gelin M, Allemand F, Guichou JF, Cotelle P, Eur J Med Chem, 2021
Programmable receptors enable bacterial biosensors to detect pathological biomarkers in clinical samples
Chang HJ, Zuniga A, Conejero I, Voyvodic PL, Gracy J, Fajardo-Ruiz E, Cohen-Gonsaud M, Cambray G, Pageaux GP, Meszaros M, Meunier L, Bonnet J, Nat Commun, 2021
Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Baneres JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gomez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, Lebon G, Cell Rep, 2021
Molecular insights into the biased signaling mechanism of the μ-opioid receptor
Cong X, Maurel D, Demene H, Vasiliauskaite-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R, Mol Cell, 2021
RNA imaging in bacteria
Rombouts S, Nollmann M, FEMS Microbiol Rev, 2021
Capsid Proteins Are Necessary for Replication of a Parvovirus
Labadie T, Garcia D, Mutuel D, Ogliastro M, Cambray G, J Virol, 2021
CD82 and Gangliosides Tune CD81 Membrane Behavior
Fernandez L, Malrieu M, Benistant C, Dosset P, Rubinstein E, Odintsova E, Berditchevski F, Milhiet PE, Int J Mol Sci, 2021
Melanotransferrin is efficiently sorted on the surface of exosomes secreted by melanoma cells
Bonhoure A, Henry L, Morille M, Aissaoui N, Bellot G, Stoebner PE, Vidal M, Melanoma Res, 2021
Ligands and DNA in the allosteric control of retinoid receptors function
Germain P, Rochel N, Bourguet W, Essays Biochem, 2021
Proteo3Dnet: a web server for the integration of structural information with interactomics data
Postic G, Andreani J, Marcoux J, Reys V, Guerois R, Rey J, Mouton-Barbosa E, Vandenbrouck Y, Cianferani S, Burlet-Schiltz O, Labesse G, Tuffery P, Nucleic Acids Res, 2021
Comparative Assessment of NMR Probes for the Experimental Description of Protein Folding Pathways with High-Pressure NMR
Van Deuren V, Yang YS, deGuillen K, Dubois C, Royer CA, Roumestand C, Barthe P, Biology (Basel), 2021
The Impact of Space and Time on the Functional Output of the Genome
Nollmann M, Bennabi I, Gotz M, Gregor T, Cold Spring Harb Perspect Biol, 2021
Correlative AFM and fluorescence imaging demonstrate nanoscale membrane remodeling and ring-like and tubular structure formation by septins
Vial A, Taveneau C, Costa L, Chauvin B, Nasrallah H, Godefroy C, Dosset P, Isambert H, Ngo KX, Mangenot S, Levy D, Bertin A, Milhiet PE, Nanoscale, 2021
A Novel Approach to the Facile Growth and Organization of Photothermal Prussian Blue Nanocrystals on Different Surfaces
Ngo G, Felix G, Dorandeu C, Devoisselle JM, Costa L, Milhiet PE, Guari Y, Larionova J, Chopineau J, Nanomaterials (Basel), 2021
Design, Synthesis and Evaluation of a Series of 1,5-Diaryl-1,2,3-triazole-4-carbohydrazones as Inhibitors of the YAP-TAZ/TEAD Complex
Gibault F, Sturbaut M, Coevoet M, Pugniere M, Burtscher A, Allemand F, Melnyk P, Hong W, Rubin BP, Pobbati AV, Guichou JF, Cotelle P, Bailly F, ChemMedChem, 2021
Exploring the conformational space of a receptor for drug design: An ERα case study
Schneider M, Pons JL, Labesse G, J Mol Graph Model, 2021
The diversity of molecular interactions involving intrinsically disordered proteins: A molecular modeling perspective
Clerc I, Sagar A, Barducci A, Sibille N, Bernado P, Cortes J, Comput Struct Biotechnol J, 2021
Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1
Ordas L, Costa L, Lozano A, Chevillard C, Calovoulos A, Kantar D, Fernandez L, Chauvin L, Dosset P, Doucet C, Heron-Milhavet L, Odintsova E, Berditchevski F, Milhiet PE, Benistant C, Cells, 2021
Single-molecule FRET on its way to structural biology in live cells
Quast RB, Margeat E, Nat Methods, 2021
The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
Labbe JC, Vigneron S, Mechali F, Robert P, Roque S, Genoud C, Goguet-Rubio P, Barthe P, Labesse G, Cohen-Gonsaud M, Castro A, Lorca T, Nat Commun, 2021
Protein-Ligand Binding Volume Determined from a Single 2D NMR Spectrum with Increasing Pressure
Skvarnavičius G, Toleikis Z, Michailovienė V, Roumestand C, Matulis D, Petrauskas V, J Phys Chem B, 2021
Arginine multivalency stabilizes protein/RNA condensates
Paloni M, Bussi G, Barducci A, Protein Sci, 2021
Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex
Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B, Sci Adv, 2021
A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays
Creusot N, Garoche C, Grimaldi M, Boulahtouf A, Chiavarina B, Bourguet W, Balaguer P, Front Endocrinol (Lausanne), 2021
Synergy and allostery in ligand binding by HIV-1 Nef
Aldehaiman AM, Momin AA, Restouin A, Wang L, Shi X, Aljedani S, Opi S, Lugari A, Shahul Hameed UF, Ponchon L, Morelli X, Huang M, Dumas C, Collette Y, Arold S, Biochem J, 2021
Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures
Delfosse V, Huet T, Harrus D, Granell M, Bourguet M, Gardia-Parege C, Chiavarina B, Grimaldi M, Le Mevel S, Blanc P, Huang D, Gruszczyk J, Demeneix B, Cianferani S, Fini JB, Balaguer P, Bourguet W, Proc Natl Acad Sci U S A, 2021
Folding of phosphodiester-linked donor-acceptor oligomers into supramolecular nanotubes in water
Perez de Carvasal K, Aissaoui N, Vergoten G, Bellot G, Vasseur JJ, Smietana M, Morvan F, Chem Commun (Camb), 2021
Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets
Sagar A, Herranz-Trillo F, Langkilde AE, Vestergaard B, Bernado P, Structure, 2021
The Dynamic Ion Motive Force Powering the Bacterial Flagellar Motor
Biquet-Bisquert A, Labesse G, Pedaci F, Nord AL, Front Microbiol, 2021
Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development
Espinola SM, Gotz M, Bellec M, Messina O, Fiche JB, Houbron C, Dejean M, Reim I, Cardozo Gizzi AM, Lagha M, Nollmann M, Nat Genet, 2021
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernandez XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linn, Nature, 2021
Pressure and Chemical Unfolding of an α-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1
Dubois C, Planelles-Herrero VJ, Tillatte-Tripodi C, Delbecq S, Mammri L, Sirkia EM, Ropars V, Roumestand C, Barthe P, Int J Mol Sci, 2021
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices
Lerner E, Barth A, Hendrix J, Ambrose B, Birkedal V, Blanchard SC, Borner R, Sung Chung H, Cordes T, Craggs TD, Deniz AA, Diao J, Fei J, Gonzalez RL, Gopich IV, Ha T, Hanke CA, Haran G, Hatzakis NS, Hohng S, Hong SC, Hugel T, Ingargiola A, Margeat E, Joo , Elife, 2021
Resolving the activation mechanism of the D99N antiterminator LicT protein
Yang Y, Gracy J, Declerck N, Demene H, J Struct Biol, 2021
Computational Methods for the Design of Recombinase Logic Circuits
Guiziou S, Bonnet J, Methods Mol Biol, 2021
An integrative structural biology analysis of von Willebrand factor binding and processing by ADAMTS-13 in solution
Del Amo-Maestro L, Sagar A, Pompach P, Goulas T, Scavenius C, Ferrero DS, Castrillo-Briceno M, Taules M, Enghild JJ, Bernado P, Xavier Gomis-Ruth F, J Mol Biol, 2021
Comment on the Optimal Parameters to Derive Intrinsically Disordered Protein Conformational Ensembles from Small-Angle X-ray Scattering Data Using the Ensemble Optimization Method
Sagar A, Jeffries CM, Petoukhov MV, Svergun DI, Bernado P, J Chem Theory Comput, 2021
MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis
Kantar D, Mur EB, Mancini M, Slaninova V, Salah YB, Costa L, Forest E, Lassus P, Geminard C, Boissiere-Michot F, Orsetti B, Theillet C, Colinge J, Benistant C, Maraver A, Heron-Milhavet L, Djiane A, Sci Rep, 2021
Interdomain linkers tailor the stability of immunoglobulin repeats in polyproteins
Joshi T, Garg S, Estana A, Cortes J, Bernado P, Das S, Kammath AR, Sagar A, Rakshit S, Biochem Biophys Res Commun, 2021
Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR)
Senicourt L, le Maire A, Allemand F, Carvalho JE, Guee L, Germain P, Schubert M, Bernado P, Bourguet W, Sibille N, J Mol Biol, 2021
Single-particle tracking photoactivated localization microscopy of membrane proteins in living plant tissues
Bayle V, Fiche JB, Burny C, Platre MP, Nollmann M, Martiniere A, Jaillais Y, Nat Protoc, 2021
Biology across scales: from atomic processes to bacterial communities through the lens of the microscope
Mignot T, Nollmann M, FEMS Microbiol Rev, 2021
Modular Imaging Scaffold for Single-Particle Electron Microscopy
Aissaoui N, Lai-Kee-Him J, Mills A, Declerck N, Morichaud Z, Brodolin K, Baconnais S, Le Cam E, Charbonnier JB, Sounier R, Granier S, Ropars V, Bron P, Bellot G, ACS Nano, 2021
Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
Bada Juarez JF, Judge PJ, Adam S, Axford D, Vinals J, Birch J, Kwan TOC, Hoi KK, Yen HY, Vial A, Milhiet PE, Robinson CV, Schapiro I, Moraes I, Watts A, Nat Commun, 2021
PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins
Lazar T, Martinez-Perez E, Quaglia F, Hatos A, Chemes LB, Iserte JA, Mendez NA, Garrone NA, Saldano TE, Marchetti J, Rueda AJV, Bernado P, Blackledge M, Cordeiro TN, Fagerberg E, Forman-Kay JD, Fornasari MS, Gibson TJ, Gomes GW, Gradinaru CC, Head-Gordon , Nucleic Acids Res, 2021
A proline rich protein from the gingival seal around teeth exhibits antimicrobial properties against Porphyromonas gingivalis
Fouillen A, Mary C, Ponce KJ, Moffatt P, Nanci A, Sci Rep, 2021
Author Correction: Molecular dissection of amyloid disaggregation by human HSP70
Wentink AS, Nillegoda NB, Feufel J, Ubartaitė G, Schneider CP, De Los Rios P, Hennig J, Barducci A, Bukau B, Nature, 2021
New Insights Into Acidithiobacillus thiooxidans Sulfur Metabolism Through Coupled Gene Expression, Solution Chemistry, Microscopy, and Spectroscopy Analyses
Camacho D, Frazao R, Fouillen A, Nanci A, Lang BF, Apte SC, Baron C, Warren LA, Front Microbiol, 2021
Laminin γ2 knockout mice rescued with the human protein exhibit enamel maturation defects
Wazen RM, Viegas-Costa LC, Fouillen A, Moffatt P, Adair-Kirk TL, Senior RM, Nanci A, Matrix Biol, 2021