Blood is the only fluid organ of the body and it is mainly composed of red blood cells (RBCs), whose high volume fraction controls blood rheology and its fundamental role of transporter. So far, the relationship between the complex molecular organization of RBCs and their behavior in microflows has not been elucidated. Our group explores the physics of blood flow with a multi-scale approach, tackling problems linking RBCs' membrane complex behavior under stress to cells flow in complex microcirculatory flows both in health and in diseases. Our team uses high-speed video-microscopy, sate-of-the-art force measurement techniques (micropipettes, optical tweezers and AFM), as well as microfluidics to produce both biomimetic flow conditions and textured lipid vesicles.