Centre de Biologie Structurale

Actualités

Séminaires

05 Aoû

Conseil de Direction 05 Aoû 2025 14:00 to 16:00
02 Sep

Conseil Labo 02 Sep 2025 14:00 to 14:30
02 Sep

Conseil de Direction 02 Sep 2025 14:00 to 16:00

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Dernières publications

In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque
Drobnic T, Cohen EJ, Calcraft T, Alzheimer M, Froschauer K, Svensson S, Hoffman WH, Singh N, Garg SG, Henderson LD, Umrekar TR, Nans A, Ribardo D, Pedaci F, Nord AL, Hochberg GKA, Hendrixson DR, Sharma CM, Rosenthal PB, Beeby M, Nat Microbiol, 2025
Sequence- and Docking-Site-Dependent Contributions to Multi-Site Phosphorylation of an Intrinsically Disordered MAPK Substrate
Orand T, Delaforge E, Chenal M, Tengo M, Herrmann T, Cortes J, Bernado P, Jensen MR, Adv Sci (Weinh), 2025
The dependence of the amino acid backbone conformation on the translated synonymous codon is not statistically significant
Gonzalez-Delgado J, Mier P, Bernado P, Neuvial P, Cortes J, Proc Natl Acad Sci U S A, 2025
A coiled-coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor
Couston J, Feuillard J, Ancelin A, Lai-Kee-Him J, Brodolin K, Chalut C, Gourdon P, Blaise M, FEBS Lett, 2025
Lipids modulate the dynamics of GPCR:beta-arrestin interaction
Gomes AAS, Di Michele M, Roessner RA, Damian M, Bisch PM, Sibille N, Louet M, Baneres JL, Floquet N, Nat Commun, 2025
Picomolar bivalent inhibitors of protein kinase CK2 active against beta-coronavirus replication
Grenier D, Lopez Molina DS, Gelin M, Mularoni A, Guichou JF, Delcros JG, Martinasso C, Yang Y, Ahnou N, Pawlotsky JM, Ahmed-Belkacem A, Krimm I, Eur J Med Chem, 2025
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
Lleres D, Gizzi AC, Nollmann M, Curr Opin Cell Biol, 2025
Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET
Bonhomme L, Bilgen E, Clerte C, Pin JP, Rondard P, Margeat E, Lamb DC, Quast RB, J Am Chem Soc, 2025
Editorial overview: Emerging perspectives in genome architecture and gene regulation
Nollmann M, Hansen AS, Curr Opin Genet Dev, 2025
Structural and Functional Characterization of the 28kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti
Mouhand A, Pissarra J, Barthe P, Roumestand C, Delbecq S, Proteins, 2025
Molecular Assemblies of Amphiphilic Oligothiophenes at the Air-Water Interface
Idriss H, Albert S, Bae C, Poyac L, Gerbier P, Bonhomme O, Lai-Kee-Him J, Ancelin A, Richeter S, Sen I, Leo K, Biance AL, Clement S, Langmuir, 2025
Single-stranded DNA drives sigma subunit loading onto mycobacterial RNA polymerase to unlock initiation-competent conformations
Vishwakarma RK, Marechal N, Morichaud Z, Blaise M, Margeat E, Brodolin K, Nucleic Acids Res, 2025
Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations
Boccalini M, Berezovska Y, Bussi G, Paloni M, Barducci A, Proc Natl Acad Sci U S A, 2025
Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli
Droghetti R, Fuchs P, Iuliani I, Firmano V, Tallarico G, Calabrese L, Grilli J, Sclavi B, Ciandrini L, Cosentino Lagomarsino M, Nat Commun, 2025
Structure of the turnip yellows virus particles
Lai-Kee-Him J, Trapani S, Boissinot S, Reinbold C, Fallet C, Ancelin A, Lecorre F, Hoh F, Ziegler-Graff V, Brault V, Bron P, Virology, 2025
Structure-guided insights into the biology of fungal effectors
Le Naour-Vernet M, Lahfa M, Maidment JHR, Padilla A, Roumestand C, deGuillen K, Kroj T, Cesari S, New Phytol, 2025
K_DSAXS: A Tool for Analyzing Binding Equilibria With SAXS Data Using Explicit Models
Gomes T, Ruiz L, Martin-Malpartida P, Bernado P, Baptista AM, Macias MJ, Cordeiro TN, J Mol Biol, 2025
Understanding the Relationship between Pressure and Temperature Unfolding of Proteins
Roumestand C, Dudas E, Puglisi R, Calio A, Barthe P, Temussi PA, Pastore A, JACS Au, 2025
GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation
Gorgues L, Smokvarska M, Mercier C, Igisch CP, Crabos A, Dongois A, Bayle V, Fiche JB, Nacry P, Nollmann M, Jaillais Y, Martiniere A, EMBO Rep, 2025
A mechanism for ligand-dependent activation of AHR
Guesdon A, Bourguet W, Trends Pharmacol Sci, 2025
AFflecto: A web server to generate conformational ensembles of flexible proteins from AlphaFold models
Pajkos M, Clerc I, Zanon C, Bernado P, Cortes J, J Mol Biol, 2025
Binding-Site Switch for Protein Kinase CK2 Inhibitors
Grenier D, Gelin M, Yang Y, Mularoni A, Guichou JF, Delcros JG, Krimm I, ChemMedChem, 2025
A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target
Carivenc C, Laconde G, Blanc P, Amblard M, Bourguet W, Delfosse V, Acta Crystallogr F Struct Biol Commun, 2025
An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice
Wang X, Zhang G, Bian Z, Chow V, Grimaldi M, Carivenc C, Sirounian S, Li H, Sladekova L, Mott S, Luperi Y, Gong Y, Costello C, Li L, Jachimowicz M, Guo M, Hu S, Wilson D, Balaguer P, Bourguet W, Mani S, Bonati L, Peng H, March J, Wang H, Wang S, Krause HM, Liu J, Nat Commun, 2025
APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus
Kaplan E, Chaloin L, Guichou JF, Berrou K, Rahimova R, Labesse G, Lionne C, ChemMedChem, 2025
Cryo-EM structure and regulation of human NAD kinase
Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G, Sci Adv, 2025
Binding-site switch of Protein Kinase CK2 inhibitors
Krimm I, Grenier D, Gelin M, Yang Cbs Cnrs Fr Y, Mularoni A, Guichou JF, Delcros JG, ChemMedChem, 2025
Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides
Pradeau-Phelut L, Alves S, Le Tareau L, Larralde C, Bernard E, Schirmer C, Lai-Kee-Him J, Lepvrier E, Bron P, Delamarche C, Garnier C, Anal Chem, 2025
Microbes Saving Lives and Reducing Suffering
Timmis K, Karahan ZC, Ramos JL, Koren O, Perez-Cobas AE, Steward K, de Lorenzo V, Caselli E, Douglas M, Schwab C, Rivero V, Giraldo R, Garmendia J, Turner RJ, Perlmutter J, Borrero de Acuna JM, Nikel PI, Bonnet J, Sessitsch A, Timmis JK, Pruzzo C, Prieto MA, Isazadeh S, Huang WE, Clarke G, Ercolini D, Haggblom M, Microb Biotechnol, 2025
Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues
Elena-Real CA, Urbanek A, Sagar A, Mohanty P, Levy G, Morato A, Fournet A, Allemand F, Sibille N, Mittal J, Sinnaeve D, Bernado P, Chemistry, 2024

Voir toutes les publications

Biophysique de la molécule unique

Bienvenue dans le departement de Biophysique des Molécules Uniques du CBS.

Nous developpons et utilisons des methodes biophysiques basées notamment sur l'observation et de manipulation de molécules uniques, afin de comprendre les propriétés des systèmes biologiques. Notre département est organisé en trois groupes de recherche :

SIM-image-241-350

Mécanismes de la ségrégation de l’ADN et du remodelage

Marcelo Nollmann

image2-241-350

Dynamique angulaire au niveau de la molécule unique

Francesco Pedaci

SPT-241-350

Structure et Dynamique d’Assemblages Nucléoprotéiques et Membranaires

Pierre-Emmanuel Milhiet

Emmanuel Margeat

EquipeB-1

EquipeB-2

EquipeB-3

EquipeB-4

EquipeA-6

Les équipes du CBS

Structure, dynamique et fonctions des biomolécules par RMN

Christian Roumestand et Nathalie Declerck
Structure et fonction de protéines hautement flexibles

Pau Bernadó et Nathalie Sibille
Biologie structurale multi-échelles (BSME)

Patrick Bron
Atelier de Biologie-Chimie-Informatique Structurale

Gilles Labesse
Les récepteurs nucléaires, intégrateurs de signaux endogènes et environnementaux

William Bourguet et Albane Le Maire
Modélisation moléculaire multi-échelle

Alessandro Barducci
Mécanismes de la ségrégation de l’ADN et du remodelage

Marcelo Nollmann
Physique et mécanique des systèmes biologiques

Manouk Abkarian et Francesco Pedaci
Biophysique Intégrative des Membranes

Pierre-Emmanuel Milhiet et Emmanuel Margeat
Biologie Synthétique

Jérôme Bonnet et Martin Cohen-Gonsaud
Modélisation moléculaire multi-échelle

Alessandro Barducci
Structure du chromosome et recombinaison en méiose

Thomas Robert
Génomique fonctionnelle et synthétique

Guillaume Cambray
Structure et fonction du récepteur AhR

Jakub Gruszczyk

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