Génomique synthétique, fonctionnelle et évolutive

Présentation

Genomes are heavily biased by evolutionary processes: this greatly limits how we can approach sequence-activity-fitness relationships.

We use DNA synthesis to precisely program sequence variants that, taken together, are most informative of a biological process. We then develop multiplex, deep-sequencing-based phenotyping assays to rapidly measure phenotypic consequences at different levels of organization. Analysis of resulting designer datasets provides unique opportunities to decipher biological complexities.

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