Tools

SelenoCYS

A protocol for the incorporation of selenomethionine and selenocysteine into recombinant proteins overexpressed in Escherichia coli based on the use of a suitable cysteine auxotrophic strain.

Strub MP., Hoh F., Sanchez JF., Strub JM., Böck A., Aumelas A. & Dumas C. (2003) "Selenomethionine and Selenocysteine Double Labeling Strategy for Crystallographic Phasing", Structure , 11, 1359-1367.

SUPERFLIP

Adapting the Charge Flipping algorithm to biological macromolecule diffraction data :
* ab initio determination of protein crystal structures at atomic resolution
* heavy atom or anomalous scatterers substructure determination

Dumas C. & van der Lee A. (2008) "Macromolecular structure solution by charge flipping", Acta Cryst D64, 864-873.

Palatinus L. & Chapuis G. (2007) "SUPERFLIP, a computer program for the solution of crystal structures by charge flipping in arbitrary dimensions", J. Appl. Cryst.40,786-790.

CINDY

A graphical NMR assignment software.
André PADILLA (CBS)

CRAACK

Consensus Rules for Amino-Acid Characterisation using a Kernel method (SVM).
The spin system typing consensus is based on the following softwares : Rescue, RescueN, Rescue2, Platon, and one other using SVM algorithm.
Benod C., Delsuc MA., Pons JL (2006) J. Chem. Inf. Model. 46 (3) 1517-1522

Additional Sponsors : ACI-IMPBio

EDMON v3

Endocrine Disruptor MONitoring - A computational tool to study interactions between nuclear hormone receptors and endocrine-disrupting chemicals
Delfosse et al, PNAS, 2012 - Doi : 10.1073/pnas.1203574109

Additional Sponsors : ANR BISCOT

Admin.Resp.	Florence Lepage
	(33) 04 67 41 79 04

Admin.Resp.	Didier Debain
	(33) 04 67 41 79 01

Manager.Assist.	Marion Boutin
	(33) 04 67 41 79 04

Centre de Biologie Structurale

Latest publications

The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited

Free-Standing DNA Origami Superlattice to Facilitate Cryo-EM Visualization of Membrane Vesicles

Multiplexed chromatin imaging reveals predominantly pairwise long-range coordination between Drosophila Polycomb genes

Phosphorylation of the F-BAR protein Hof1 drives septin ring splitting in budding yeast

1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors-a PARC project

1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM

Hi-M: A Multiplex Oligopaint FISH Method to Capture Chromatin Conformations In Situ and Accompanying Open-Source Acquisition Software

Emergence of slip-ideal-slip behavior in tip-links serve as force filters of sound in hearing

Increases in cyclin A/Cdk activity and in PP2A-B55 inhibition by FAM122A are key mitosis-inducing events

pyHiM: a new open-source, multi-platform software package for spatial genomics based on multiplexed DNA-FISH imaging

LactoSpanks: A Collection of IPTG Inducible Promoters for the Commensal Lactic Acid Bacteria Lactobacillus gasseri

PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins

An innovative in situAFM system for a soft X-ray spectromicroscopy synchrotron beamline

Critical micellar concentration determination of pure phospholipids and lipid-raft and their mixtures with cholesterol

Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric alphaD pocket

Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds

Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration

The genome of a bunyavirus cannot be defined at the level of the viral particle but only at the scale of the viral population

A single-domain intrabody targeting the follicle-stimulating hormone receptor impacts FSH-induced G protein-dependent signalling

Structure-function relationships in protein homorepeats

3D chromatin interactions involving Drosophila insulators are infrequent but preferential and arise before TADs and transcription

A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation

wTSA-CRAFT: an open-access web server for rapid analysis of thermal shift assay experiments

Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings

Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae

Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria

Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction

The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia-reperfusion injury via mitoprotection

Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies

SelenoCYS

SUPERFLIP

CINDY

CRAACK

EDMON v3

More Articles ...

CBS Teams

Structure, Dynamics and Function of biomolecules by NMR

Structure and function of highly flexible proteins

Multi-scale structural biology

ABCIS

Nuclear Receptors as Integrators of Endogenous and Environmental Signals

Mechanisms of DNA Segregation and Remodelling

Physics and mechanics of biological systems

Integrative Biophysics of Membranes

Multiscale Biomolecular Modeling

Synthetic Biology

Chromosome structure and homologous recombination in meiosis

Functional and synthetic genomics

Structure and function of the aryl hydrocarbon receptor

Postdoctoral position – Team Integrative Biophysics of Membranes

Postdoctoral position – Team Integrative Biophysics of Membranes

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