Centre de Biologie Structurale

Séminaires

06 Mai

Conseil de Direction 06 Mai 2025 14:00 to 16:00
12 Mai

Biophysics Seminar: Manu/Pem team 12 Mai 2025 11:00 to 12:00
13 Mai

Introductory course on fluid mechanics & microfluidics -VI-Manouk Abkarian 13 Mai 2025 12:30 to 13:45

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Dernières publications

GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation
Gorgues L, Smokvarska M, Mercier C, Igisch CP, Crabos A, Dongois A, Bayle V, Fiche JB, Nacry P, Nollmann M, Jaillais Y, Martiniere A, EMBO Rep, 2025
A mechanism for ligand-dependent activation of AHR
Guesdon A, Bourguet W, Trends Pharmacol Sci, 2025
A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target
Carivenc C, Laconde G, Blanc P, Amblard M, Bourguet W, Delfosse V, Acta Crystallogr F Struct Biol Commun, 2025
An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice
Wang X, Zhang G, Bian Z, Chow V, Grimaldi M, Carivenc C, Sirounian S, Li H, Sladekova L, Mott S, Luperi Y, Gong Y, Costello C, Li L, Jachimowicz M, Guo M, Hu S, Wilson D, Balaguer P, Bourguet W, Mani S, Bonati L, Peng H, March J, Wang H, Wang S, Krause HM, Liu J, Nat Commun, 2025
Cryo-EM structure and regulation of human NAD kinase
Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G, Sci Adv, 2025
Binding-Site Switch for Protein Kinase CK2 Inhibitors
Grenier D, Gelin M, Yang Y, Mularoni A, Guichou JF, Delcros JG, Krimm I, ChemMedChem, 2025
Binding-site switch of Protein Kinase CK2 inhibitors
Krimm I, Grenier D, Gelin M, Yang Cbs Cnrs Fr Y, Mularoni A, Guichou JF, Delcros JG, ChemMedChem, 2025
APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus
Kaplan E, Chaloin L, Guichou JF, Berrou K, Rahimova R, Labesse G, Lionne C, ChemMedChem, 2025
Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides
Pradeau-Phelut L, Alves S, Le Tareau L, Larralde C, Bernard E, Schirmer C, Lai-Kee-Him J, Lepvrier E, Bron P, Delamarche C, Garnier C, Anal Chem, 2025
Microbes Saving Lives and Reducing Suffering
Timmis K, Karahan ZC, Ramos JL, Koren O, Perez-Cobas AE, Steward K, de Lorenzo V, Caselli E, Douglas M, Schwab C, Rivero V, Giraldo R, Garmendia J, Turner RJ, Perlmutter J, Borrero de Acuna JM, Nikel PI, Bonnet J, Sessitsch A, Timmis JK, Pruzzo C, Prieto MA, Isazadeh S, Huang WE, Clarke G, Ercolini D, Haggblom M, Microb Biotechnol, 2025
Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues
Elena-Real CA, Urbanek A, Sagar A, Mohanty P, Levy G, Morato A, Fournet A, Allemand F, Sibille N, Mittal J, Sinnaeve D, Bernado P, Chemistry, 2024
Measuring Bacterial Flagellar Motor Dynamics via a Bead Assay
Hoffmann WH, Biquet-Bisquert A, Pedaci F, Nord AL, Methods Mol Biol, 2024
Determining the Relative Affinity of ORPs for Lipid Ligands Using Fluorescence and Thermal Shift Assays
Delfosse V, Drin G, Methods Mol Biol, 2024
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants
le Maire A, Bourguet W, Annu Rev Pharmacol Toxicol, 2024
Structural Insights Into Thyroid Hormone Receptors
Tambones I, le Maire A, Endocrinology, 2024
Structural basis of orientated asymmetry in a mGlu heterodimer
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J, Nat Commun, 2024
Structure of the aminoterminal domain of the birnaviral multifunctional VP3 protein and its unexplored critical role
Ferrero DS, Gimenez MC, Sagar A, Rodriguez JM, Caston JR, Terebiznik MR, Bernado P, Verdaguer N, PNAS Nexus, 2024
Microbial biosensors for diagnostics, surveillance and epidemiology: Today's achievements and tomorrow's prospects
Capin J, Chabert E, Zuniga A, Bonnet J, Microb Biotechnol, 2024
Towards the design of ligands of the internal pocket TEADs C-terminal domain
Toulotte F, Coevoet M, Liberelle M, Bailly F, Zagiel B, Gelin M, Allemand F, Fourquet P, Melnyk P, Guichou JF, Cotelle P, Eur J Med Chem, 2024
Weighted families of contact maps to characterize conformational ensembles of (highly-)flexible proteins
Gonzalez-Delgado J, Bernado P, Neuvial P, Cortes J, Bioinformatics, 2024
Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies
Fouillen A, Couvineau P, Gaibelet G, Riche S, Orcel H, Mendre C, Kanso A, Lanotte R, Nguyen J, Dimon J, Urbach S, Sounier R, Granier S, Bonnet D, Cong X, Mouillac B, Demene H, Comput Struct Biotechnol J, 2024
Molecular model of a bacterial flagellar motor in situreveals a parts-list of protein adaptations to increase torque
Drobnic T, Cohen EJ, Calcraft T, Alzheimer M, Froschauer K, Svensson S, Hoffmann WH, Singh N, Garg SG, Henderson L, Umrekar TR, Nans A, Ribardo D, Pedaci F, Nord AL, Hochberg GKA, Hendrixson DR, Sharma CM, Rosenthal PB, Beeby M, bioRxiv, 2024
The flavonoid resokaempferol improves insulin secretion from healthy and dysfunctional pancreatic beta-cells
Gautheron G, Peraldi-Roux S, Vaille J, Belhadj S, Patyra A, Bayle M, Youl E, Omhmmed S, Guyot M, Cros G, Guichou JF, Uzan B, Movassat J, Quignard JF, Neasta J, Oiry C, Br J Pharmacol, 2024
Split Reporters Facilitate Monitoring of Gene Expression and Peptide Production in Linear Cell-Free Transcription-Translation Systems
Levrier A, Capin J, Mayonove P, Karpathakis II, Voyvodic P, DeVisch A, Zuniga A, Cohen-Gonsaud M, Cabantous S, Noireaux V, Bonnet J, ACS Synth Biol, 2024
A molten globule ensemble primes Arf1-GDP for the nucleotide switch
Koduru T, Hantman N, Peters EV, Jaworek MW, Wang J, Zhang S, McCallum SA, Gillilan RE, Fossat MJ, Roumestand C, Sagar A, Winter R, Bernado P, Cherfils J, Royer CA, Proc Natl Acad Sci U S A, 2024
The TOPOVIBL meiotic DSB formation protein: new insights from its biochemical and structural characterization
Diagouraga B, Tambones I, Carivenc C, Bechara C, Nadal M, de Massy B, le Maire A, Robert T, Nucleic Acids Res, 2024
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer-promoter communication
Denaud S, Bardou M, Papadopoulos GL, Grob S, Di Stefano M, Sabaris G, Nollmann M, Schuettengruber B, Cavalli G, Nat Struct Mol Biol, 2024
Quantifying surface tension and viscosity in biomolecular condensates by FRAP-ID
Santamaria A, Hutin S, Doucet CM, Zubieta C, Milhiet PE, Costa L, Biophys J, 2024
A fully sequenced collection of homozygous EMS mutants for forward and reverse genetic screens in Arabidopsis thaliana
Carrere S, Routaboul JM, Savourat P, Bellenot C, Lopez H, Sahoo A, Quiroz Monnens T, Ricou A, Camilleri C, Declerck N, Laufs P, Mercier R, Noel LD, Plant J, 2024
@TOME 3.0: Interfacing Protein Structure Modeling and Ligand Docking
Pons JL, Reys V, Grand F, Moreau V, Gracy J, Exner TE, Labesse G, J Mol Biol, 2024

Voir toutes les publications

Microscopies Optiques

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Matériels techniques

Etude type en Biophysique

o 1 : Objectif

Cette plateforme propose un ensemble d'approches basées sur la spectroscopie de fluorescence applicables à des études d'interactions entre biomolécules et de dynamique structurale (repliement, assemblage, diffusion, fluctuations, changements conformationnels). Contactez Emmanuel Margeat ou Caroline Clerte pour discuter des possibilités d'utilisation de la plateforme et de la conception des expériences.
Ci dessous une présentation des différentes techniques utilisées au CBS (bientôt disponible).

Les équipes du CBS

Structure, dynamique et fonctions des biomolécules par RMN

Christian Roumestand et Nathalie Declerck
Structure et fonction de protéines hautement flexibles

Pau Bernadó et Nathalie Sibille
Biologie structurale multi-échelles (BSME)

Patrick Bron
Atelier de Biologie-Chimie-Informatique Structurale

Gilles Labesse
Les récepteurs nucléaires, intégrateurs de signaux endogènes et environnementaux

William Bourguet et Albane Le Maire
Modélisation moléculaire multi-échelle

Alessandro Barducci
Mécanismes de la ségrégation de l’ADN et du remodelage

Marcelo Nollmann
Physique et mécanique des systèmes biologiques

Manouk Abkarian et Francesco Pedaci
Biophysique Intégrative des Membranes

Pierre-Emmanuel Milhiet et Emmanuel Margeat
Biologie Synthétique

Jérôme Bonnet et Martin Cohen-Gonsaud
Modélisation moléculaire multi-échelle

Alessandro Barducci
Structure du chromosome et recombinaison en méiose

Thomas Robert
Génomique fonctionnelle et synthétique

Guillaume Cambray
Structure et fonction du récepteur AhR

Jakub Gruszczyk

Resp. Admin.	Didier Debain
	(33) 04 67 41 79 01

Resp.Admin.	Florence Lepage
	(33) 04 67 41 79 04

Assist.Gest.	Marion Boutin
	(33) 04 67 41 79 04

Centre de Biologie Structurale

Dernières publications

GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation

A mechanism for ligand-dependent activation of AHR

A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target

An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice

Cryo-EM structure and regulation of human NAD kinase

Binding-Site Switch for Protein Kinase CK2 Inhibitors

Binding-site switch of Protein Kinase CK2 inhibitors

APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus

Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides

Microbes Saving Lives and Reducing Suffering

Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues

Measuring Bacterial Flagellar Motor Dynamics via a Bead Assay

Determining the Relative Affinity of ORPs for Lipid Ligands Using Fluorescence and Thermal Shift Assays

What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants

Structural Insights Into Thyroid Hormone Receptors

Structural basis of orientated asymmetry in a mGlu heterodimer

Structure of the aminoterminal domain of the birnaviral multifunctional VP3 protein and its unexplored critical role

Microbial biosensors for diagnostics, surveillance and epidemiology: Today's achievements and tomorrow's prospects

Towards the design of ligands of the internal pocket TEADs C-terminal domain

Weighted families of contact maps to characterize conformational ensembles of (highly-)flexible proteins

Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies

Molecular model of a bacterial flagellar motor in situreveals a parts-list of protein adaptations to increase torque

The flavonoid resokaempferol improves insulin secretion from healthy and dysfunctional pancreatic beta-cells

Split Reporters Facilitate Monitoring of Gene Expression and Peptide Production in Linear Cell-Free Transcription-Translation Systems

A molten globule ensemble primes Arf1-GDP for the nucleotide switch

The TOPOVIBL meiotic DSB formation protein: new insights from its biochemical and structural characterization

A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer-promoter communication

Quantifying surface tension and viscosity in biomolecular condensates by FRAP-ID

A fully sequenced collection of homozygous EMS mutants for forward and reverse genetic screens in Arabidopsis thaliana

@TOME 3.0: Interfacing Protein Structure Modeling and Ligand Docking

Microscopies Optiques

Les équipes du CBS

Postdoctoral position – Team Integrative Biophysics of Membranes

Structure, dynamique et fonctions des biomolécules par RMN

Structure et fonction de protéines hautement flexibles

Biologie structurale multi-échelles (BSME)

Atelier de Biologie-Chimie-Informatique Structurale

Les récepteurs nucléaires, intégrateurs de signaux endogènes et environnementaux

Mécanismes de la ségrégation de l’ADN et du remodelage

Physique et mécanique des systèmes biologiques

Biophysique Intégrative des Membranes

Modélisation moléculaire multi-échelle

Biologie Synthétique

Structure du chromosome et recombinaison en méiose

Génomique fonctionnelle et synthétique

Structure et fonction du récepteur AhR

Postdoctoral position – Team Integrative Biophysics of Membranes

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