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Centre de Biologie Structurale
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News
Two folds, many faces: The Magnaporthe oryzae MAX effector AVR-Pia targets novel rice HMA domain-containing proteins
Science-Art film project : Resonances
CNRS Year of Engineering
Anjelica Kucinic awarded best poster at FNANO 2026
Registrations are now open for ESAB 2026 Conference, June 16-19 2026, Montpellier
BSI – Bordeaux 2025
ESAB 2026 Conference, June 16-19 2026
Dévoilement du projet d’extension du CBS - 19/09/2025
Synonymous codons do not influence the amino-acid backbone conformation
Pierre-Emmanuel Milhiet received into the Order of Academic Palms
Mirror doctoral project: Designing remote-accessible bioelectronic cell systems for autonomous biomedical solutions
Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations
Join the qbio Master's Program [Quantitative Biology: Molecular Mechanisms of Living Systems (parcours IDIL)] Q&A Session on Monday, February 10!
Le Centre de Biologie Structurale (CBS) de Montpellier s’engage à accueillir 6 stagiaires de seconde générale et technologique, du 16 au 27 juin 2025
Ashley Nord awarded with the bronze medal of CNRS
When cryo-electron tomography uncovers the in cellulo structural organization of the Chikungunya virus replication complex
2D DNA-origami assembly for Cryo-EM Applications
The “Impulscience” prize awarded to Ashley Nord
Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria
Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction
Combining mechanical and superresolution measurements to reveal the plasticity of the Nuclear Pore Complexes
The structure of pathogenic huntingtin exon-1 defines the bases of its aggregation propensity
Structure of the dioxin receptor (AHR) revealed by cryo-electron microscopy
Get out of here, let me get on it ! The G protein and the beta-arrestiin
Original structure and regulation by acetylation of human NADK2
DNA origami to explore cell mechanotransduction
The C-terminal domains of GPCR are disordered with transient secondary structures
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Latest publications
Correction: The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited
Lahfa M, Barthe P, deGuillen K, Cesari S, Raji M, Kroj T, Le Naour-Vernet M, Hoh F, Gladieux P, Roumestand C, Gracy J, Declerck N, Padilla A, PLoS Pathog, 2026
Filtering Disordered Protein Conformations by NMR Residual Dipolar Couplings
Botnari M, Sibille N, Lin JH, Malliavin TE, J Phys Chem B, 2026
ATRA resistance conferred by a clustered subset of hotspot PML::RARA mutations enhancing basal repression rather than precluding transactivation
Barbosa GM, Yuan H, Tambones I, Stote RH, Wu HC, De The H, Le Maire A, Geoffroy MC, Haematologica, 2026
Recent advances on structure and dynamics of G protein-coupled receptors using single-molecule Foerster resonance energy transfer
Quast RB, Margeat E, Curr Opin Struct Biol, 2026
Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes
Mallet M, Martin Y, Carvalho JE, Guchen E, Betous R, Bechara C, Lespine A, Schubert M, Bourguet W, le Maire A, PLoS Pathog, 2026
Optimization of the antiviral spectrum of cyclophilin inhibitors targeting respiratory viruses
Softic L, Jimenez-Araya B, Ahnou N, Duval M, Nevers Q, Brillet R, Guichou J-F, Rodriguez C, Bruscella P, Pawlotsky J-M, Fourati S, Ahmed-Belkacem A, Antimicrob Agents Chemother, 2026
Mechanisms controlling the plasma membrane targeting and the nanodomain organization of the plant SPFH protein HIR2
Danek M, Hdedeh O, Amo J, Boutet J, Neubergerova M, Safi H, Abuzeineh A, Martin-Barranco A, Fiche JB, Mercier C, Dumortier B, Krouk G, Nollmann M, Pleskot R, Boutte Y, Santoni V, Mongrand S, Martiniere A, Zelazny E, Plant J, 2026
Two folds, many faces: The Magnaporthe oryzae MAX effector AVR-Pia targets novel rice HMA domain-containing proteins
Maidment JHR, Saile SC, Bocquet A, Thivolle C, Bourcet L, Planel LF, Gelin M, Kroj T, Padilla A, deGuillen K, Cesari S, PLoS Pathog, 2026
Membrane protein solubilization and structure determination using de novo-designed proteins
Mihaljevic L, Kim DE, Bandawane PD, Eisenach HE, Borst AJ, Courbet A, Weidle C, Carr KD, Bettin E, Liu Q, Trejos AT, Majumder S, Kokane S, Stevens A, Muratspahic E, Schlichthaerle T, Exposit M, Li X, Lamb M, Azcarraga Murray AN, Ravichandran R, Williams EC, Hu S, Stuart L, Grillova L, Thomson NR, Landreh M, Chang P, Giacani L, Caimano MJ, Hawley KL, King NP, Baker D, Science, 2026
Challenging cases for AlphaFold: two multidomain proteins with zinc-binding-, phosphorylation- or dimerization-driven conformational changes
Yang Y, Demene H, Eur Biophys J, 2026
Distinct Spatial Organisation of Rho and RNA Polymerase in Salmonella Cells
Bossi L, Le Bars R, Black JC, Buggiani J, Clerte C, Do TD, Margeat E, Boudvillain M, Figueroa-Bossi N, Mol Microbiol, 2026
An integrated structural and functional profiling approach uncovers the mechanisms of pregnane X receptor binding and activation by pharmaceutical and environmental compounds
Derosa Q, Carivenc C, Sirounian S, Grimaldi M, Boulahtouf A, Delfosse V, Balaguer P, Bourguet W, Mol Pharmacol, 2026
Pilot metaproteomic profiling reveals bacterial diversity and potential medical and veterinary relevance of tick microbiomes in northern Algeria
Kernif T, Lozano C, Khardine FA, Medrouh B, Hachid A, Fernandez B, Eddaikra N, Delbecq S, Armengaud J, Sereno D, Holzmuller P, Sci Rep, 2026
Bridging cells with devices: emerging reporters and physical interfaces for bacterial biosensors
Capin J, Sasson C, Cattoni DI, Bonnet J, Curr Opin Biotechnol, 2026
Heterogeneity and multi-scale dynamics in the molecular bearing of the bacterial flagellum
Rieu M, Xu D, Subramaniam G, Nord AL, Courbet A, El Sayyed H, Berry RM, Nat Commun, 2026
Biologically relevant finite-size effects in a driven lattice gas with particle pausing and dynamical defects
Keisers J, Zovo LVD, Kern N, Ciandrini L, Phys Rev E, 2026
Differential Properties of NS1 Glycoproteins in West Nile and Usutu Viruses
Revel J, Leroy J, Delbecq S, Constant O, Marty F, Naili C, Barthes A, Nagy A, Schmidt-Chanasit J, Cadar D, Abd Rahaman NY, Lajoix AD, Desmetz C, Simonin Y, Emerg Microbes Infect, 2026
DL3D: visual representation of conformational ensembles of domain-linker-domain proteins
Carriere L, Bartels S, Zanon C, Bernado P, Cortes J, BMC Bioinformatics, 2026
Distinct 2-phenylimidazo[1,2-a]pyridine derivatives that inhibit breast cancer cell proliferation identified as AHR ligands
Koellisch K, Blattner C, Motta S, Wesslowski J, Rothley M, Buchel S, Sirounian S, Segatto I, Weber HT, Muller J, Grimaldi M, Stober J, Wammetsberger Z, Pan M, Houtman R, Grathwol CW, Lin LW, Buluwela L, Kolluri SK, Mytzka D, Ali S, Jung N, Balaguer P, Thaler S, Belletti B, Bonati L, Bourguet W, Brase S, Davidson G, Cato ACB, iScience, 2026
Unveiling the Impact of Drug-Sensitive Mutations on HIV-1 Protease Dynamics: A Molecular Dynamics Simulation Study of the T12A, L63Q, and H69N Variants
Srihi H, Abid N, Fabeni L, Precone C, Demene H, Chillemi G, Int J Mol Sci, 2026
LinkCraft: An interactive tool for the design of flexible linkers
Pajkos M, Barrera P, Clerc I, Zanon C, Bernado P, Cortes J, J Mol Biol, 2026
Membrane cholesterol modulates engagement of beta-arrestin with the ghrelin receptor
Berto L, Henri P, Damian M, Cantel S, Fehrentz JA, Sibille N, Di Michele M, Baneres JL, Commun Biol, 2026
Statistical models to characterize colon tumor stiffness heterogeneity through representative atomic force microscopy maps
Gadouas G, Tosato G, Costa L, Thierry AR, Ravel P, Mazard T, Milhiet PE, Benistant C, Lopez-Crapez E, Colinge J, Sci Rep, 2026
Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes
Rachenne F, Schneider N, Rey-Cadilhac F, Serrato-Pomar I, Pruvost L, Di Pietro L, Dainat J, Vernet A, Cazevieille C, Ancelin A, Lai Kee Him J, Jansen S, Miot EF, Fraering J, Simon L, Misse D, Morille M, Hammann P, Seveno M, Urbach S, Dallmeier K, Marois E, Pompon J, Proc Natl Acad Sci U S A, 2026
Corrigendum to Adaptation of Folding and Function of a Nuclease from the Cold Deep Sea [J. Mol. Biol. 438(4) (2026) 169602]
Koduru T, Barthe P, Hantman N, Guillen K, McCallum SA, Morgan JE, Yee EF, Leonardi P, Foland J, Roumestand C, Royer CA, J Mol Biol, 2026
CF2H: a cell-free two-hybrid platform for rapid protein binder screening
Capin J, Mayonove P, DeVisch A, Becher A, Ngo G, Courbet A, Ragotte RJ, Cohen Gonsaud M, Espeut J, Bonnet J, Nat Commun, 2026
Toward a unified framework for determining conformational ensembles of disordered proteins
Ghafouri H, Kaderavek P, Melo AM, Aspromonte MC, Bernado P, Cortes J, Dosztanyi Z, Erdos G, Feig M, Janson G, Lindorff-Larsen K, Mulder FAA, Nagy P, Pestell R, Piovesan D, Schiavina M, Schuler B, Sibille N, Tesei G, Tompa P, Vendruscolo M, Vondrasek J, Vranken W, Zidek L, Tosatto SCE, Monzon AM, Nat Methods, 2026
Revealing protein dynamics with high-pressure NMR
Roche J, Roumestand C, Royer CA, Q Rev Biophys, 2026
Staphylococcus epidermidisDnaK alters biofilm formation and proteome in Staphylococcus aureusCIP 107093
Kayser C, Druart K, Bouscasse E, Matondo M, Chane A, Hoh F, Groboillot A, Barbey C, Merieau A, Latour X, Soule P, Muhle E, Norris V, Konto-Ghiorghi Y, Front Microbiol, 2026
Mechanistic Insights of BPA Alternatives on PPARgamma Binding and the Consequence on Adipocyte Differentiation
Flores Gomez D, Korpel N, Grimaldi M, Carivenc C, Balaguer P, Bourguet W, Kamstra JH, Environ Sci Technol, 2026
Teams
Structure and function of highly flexible proteins
Team leaders: Pau Bernadó & Nathalie Sibille
Multi-scale structural biology
Team leader : Patrick Bron
Synthetic Biology
Teams leaders: Jérôme Bonnet et Martin Cohen-Gonsaud
Mechanisms of DNA Segregation and Remodelling
Team leader : Marcelo Nollmann
Integrative Biophysics of Membranes
Team leaders : Pierre-Emmanuel Milhiet et Emmanuel Margeat
Synthetic, Functional and Evolutionary Genomics
Team leader : Guillaume Cambray
Structure and function of the aryl hydrocarbon receptor (ATIP-Avenir)
Team leader : J Gruszczyk
ABCIS: Advanced Biology, Chemistry, Informatics Studio
Team leader Gilles Labesse
Nuclear Receptors as Integrators of Endogenous and Environmental Signals
Team leaders : William Bourguet and Albane Le Maire
Chromosome structure and homologous recombination in meiosis
Team leader : Thomas Robert
Multiscale Biomolecular Modeling
Team leader : Alessandro Barducci
Equipments
Instrumentation at the CBS
We have a large panel of instruments to support our research. We also perform technological developments for dedicated applications.
Softwares
Software Development at the CBS
The Centre de Biochimie Structurale develops and hosts software tools for research.
Internships
Postdoctoral position – Team Multiscale Biomolecular Modeling
A two-year postdoctoral position is available in the Multiscale Biomolecular Modeling team at the Centre de Biologie Structurale (CBS) in Montpellier, starting in early 2026 (flexible). This position offers a unique opportunity to explore how RNA molecules shape cellular organization through phase separation, combining physics-based modeling with close collaboration across disciplines.
Contact :
| Director | Emmanuel Margeat |
| Deputy directors | Vanessa Delfosse Martin Cohen-Gonsaud |
| Admin.Resp. | Florence Lepage |
| (33) 04 67 41 79 01 |
| Manager.Assist. | Marion Boutin |
| (33) 04 67 41 79 04 |
