2023
The genome of a bunyavirus cannot be defined at the level of the viral particle but only at the scale of the viral population
Yvon M, German TL, Ullman DE, Dasgupta R, Parker MH, Ben-Mahmoud S, Verdin E, Gognalons P, Ancelin A, Lai Kee Him J, Girard J, Vernerey MS, Fernandez E, Filloux D, Roumagnac P, Bron P, Michalakis Y, Blanc S, Proc Natl Acad Sci U S A, 2023
A single-domain intrabody targeting the follicle-stimulating hormone receptor impacts FSH-induced G protein-dependent signalling
Raynaud P, Jugnarain V, Vaugrente O, Vallet A, Boulo T, Gauthier C, Inoue A, Sibille N, Gauthier C, Jean-Alphonse F, Reiter E, Crepieux P, Bruneau G, FEBS Lett, 2023
Structure-function relationships in protein homorepeats
Elena-Real CA, Mier P, Sibille N, Andrade-Navarro MA, Bernado P, Curr Opin Struct Biol, 2023
PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins
Ghafouri H, Lazar T, Del Conte A, Tenorio Ku LG, Tompa P, Tosatto SCE, Monzon AM, Aspromonte MC, Bernado P, Chaves-Arquero B, Chemes LB, Clementel D, Cordeiro TN, Elena-Real CA, Feig M, Felli IC, Ferrari C, Forman-Kay JD, Gomes T, Gondelaud F, Gradinaru CC, Ha-Duong T, Head-Gordon T, Heidarsson PO, Janson G, Jeschke G, Leonardi E, Liu ZH, Longhi S, Lund XL, Macias MJ, Martin-Malpartida P, Mercadante D, Mouhand A, Nagy G, Nugnes MV, Perez-Canadillas JM, Pesce G, Pierattelli R, Piovesan D, Quaglia F, Ricard-Blum S, Robustelli P, Sagar A, Salladini E, Senicourt L, Sibille N, Teixeira JMC, Tsangaris TE, Varadi M, Nucleic Acids Res, 2023
3D chromatin interactions involving Drosophila insulators are infrequent but preferential and arise before TADs and transcription
Messina O, Raynal F, Gurgo J, Fiche JB, Pancaldi V, Nollmann M, Nat Commun, 2023
A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation
Valverde JM, Dubra G, Phillips M, Haider A, Elena-Real C, Fournet A, Alghoul E, Chahar D, Andres-Sanchez N, Paloni M, Bernado P, van Mierlo G, Vermeulen M, van den Toorn H, Heck AJR, Constantinou A, Barducci A, Ghosh K, Sibille N, Knipscheer P, Krasinska L, Fisher D, Altelaar M, Nat Commun, 2023
wTSA-CRAFT: an open-access web server for rapid analysis of thermal shift assay experiments
Reys V, Kowalewski J, Gelin M, Lionne C, Bioinform Adv, 2023
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings
Fnaiche A, Melin L, Suarez NG, Paquin A, Vu V, Li F, Allali-Hassani A, Bolotokova A, Allemand F, Gelin M, Cotelle P, Woo S, LaPlante SR, Barsyte-Lovejoy D, Santhakumar V, Vedadi M, Guichou JF, Annabi B, Gagnon A, Bioorg Med Chem Lett, 2023
Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria
Rombouts S, Mas A, Le Gall A, Fiche JB, Mignot T, Nollmann M, Nat Commun, 2023
Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae
Le Naour-Vernet M, Charriat F, Gracy J, Cros-Arteil S, Ravel S, Veillet F, Meusnier I, Padilla A, Kroj T, Cesari S, Gladieux P, PLoS Pathog, 2023
Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction
Guillien M, Mouhand A, Sagar A, Fournet A, Allemand F, Pereira GAN, Thureau A, Bernado P, Baneres JL, Sibille N, Structure, 2023
The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia-reperfusion injury via mitoprotection
Kheyar A, Ahnou N, Ahmed-Belkacem A, Hulin A, Pressiat C, Ghaleh B, Guichou JF, Morin D, Pawlotsky JM, Teixeira-Clerc F, JHEP Rep, 2023
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies
Elena-Real CA, Urbanek A, Imbert L, Morato A, Fournet A, Allemand F, Sibille N, Boisbouvier J, Bernado P, ACS Chem Biol, 2023
Does a Similar 3D Structure Mean a Similar Folding Pathway? The Presence of a C-Terminal alpha-Helical Extension in the 3D Structure of MAX60 Drastically Changes the Folding Pathway Described for Other MAX-Effectors from Magnaporthe oryzae
Lahfa M, Mouhand A, deGuillen K, Barthe P, Kroj T, Padilla A, Roumestand C, Molecules, 2023
Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs
Gedeon A, Ayoub N, Brule S, Raynal B, Karimova G, Gelin M, Mechaly A, Haouz A, Labesse G, Munier-Lehmann H, Protein Sci, 2023
Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins
Malinverni D, Zamuner S, Rebeaud ME, Barducci A, Nillegoda NB, De Los Rios P, Proc Natl Acad Sci U S A, 2023
Isothermal self-assembly of multicomponent and evolutive DNA nanostructures
Rossi-Gendron C, El Fakih F, Bourdon L, Nakazawa K, Finkel J, Triomphe N, Chocron L, Endo M, Sugiyama H, Bellot G, Morel M, Rudiuk S, Baigl D, Nat Nanotechnol, 2023
Structure, dynamics and transferability of the metal-dependent polyhistidine tetramerization motif TetrHis for single-chain Fv antibodies
Healey RD, Couillaud L, Hoh F, Mouhand A, Fouillen A, Couvineau P, Granier S, Leyrat C, Commun Chem, 2023
Linkers in fragment-based drug design: an overview of the literature
Grenier D, Audebert S, Preto J, Guichou JF, Krimm I, Expert Opin Drug Discov, 2023
Insights into the structure, functional perspective, and pathogenesis of ZIKV: an updated review
Bhat EA, Ali T, Sajjad N, Kumar R, Bron P, Biomed Pharmacother, 2023
1H, 13C and 15N backbone and side-chain resonance assignments of BmSA1, the surface antigen of Babesia microti
Mouhand A, Pissarra J, Delbecq S, Roumestand C, Barthe P, Biomol NMR Assign, 2023
SecretoMyc, a web-based database on mycobacteria secreted proteins and structure-based homology identification using bio-informatics tools
Gracy J, Vallejos-Sanchez K, Cohen-Gonsaud M, Tuberculosis (Edinb), 2023
Cyclophilin A Isomerisation of Septin 2 Mediates Abscission during Cytokinesis
Gorry RL, Brennan K, Lavin PTM, Mazurski T, Mary C, Matallanas D, Guichou JF, Mc Gee MM, Int J Mol Sci, 2023
Phase separation and molecular ordering of the prion-like domain of the Arabidopsis thermosensory protein EARLY FLOWERING 3
Hutin S, Kumita JR, Strotmann VI, Dolata A, Ling WL, Louafi N, Popov A, Milhiet PE, Blackledge M, Nanao MH, Wigge PA, Stahl Y, Costa L, Tully MD, Zubieta C, Proc Natl Acad Sci U S A, 2023
Development of new approach methods for the identification and characterization of endocrine metabolic disruptors-a PARC project
Braeuning A, Balaguer P, Bourguet W, Carreras-Puigvert J, Feiertag K, Kamstra JH, Knapen D, Lichtenstein D, Marx-Stoelting P, Rietdijk J, Schubert K, Spjuth O, Stinckens E, Thedieck K, van den Boom R, Vergauwen L, von Bergen M, Wewer N, Zalko D, Front Toxicol, 2023
Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism
Tarres-Sole A, Battistini F, Gerhold JM, Pietrement O, Martinez-Garcia B, Ruiz-Lopez E, Lyonnais S, Bernado P, Roca J, Orozco M, Le Cam E, Sedman J, Sola M, Nucleic Acids Res, 2023
Concerted conformational changes control metabotropic glutamate receptor activity
Lecat-Guillet N, Quast RB, Liu H, Bourrier E, Moller TC, Rovira X, Soldevila S, Lamarque L, Trinquet E, Liu J, Pin JP, Rondard P, Margeat E, Sci Adv, 2023
Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1
Elena-Real CA, Urbanek A, Lund XL, Morato A, Sagar A, Fournet A, Estana A, Bellande T, Allemand F, Cortes J, Sibille N, Melki R, Bernado P, Structure, 2023
Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion
Lohia R, Allegrini B, Berry L, Guizouarn H, Cerdan R, Abkarian M, Douguet D, Honore E, Wengelnik K, Cell Mol Life Sci, 2023
Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
Alghoul E, Paloni M, Takedachi A, Urbach S, Barducci A, Gaillard PH, Basbous J, Constantinou A, Mol Cell, 2023
Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity
Van Bael J, Vandenbulcke A, Ahmed-Belkacem A, Guichou JF, Pawlotsky JM, Samyn J, Barendrecht AD, Maas C, De Meyer SF, Vanhoorelbeke K, Tersteeg C, Int J Mol Sci, 2023
Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from Streptococcus pneumoniae
Hertzog M, Perry TN, Dupaigne P, Serres S, Morales V, Soulet AL, Bell JC, Margeat E, Kowalczykowski SC, Le Cam E, Fronzes R, Polard P, Nucleic Acids Res, 2023
A Tripartite Complex HIV-1 Tat-Cyclophilin A-Capsid Protein Enables Tat Encapsidation That Is Required for HIV-1 Infectivity
Schatz M, Marty L, Ounadjela C, Tong PBV, Cardace I, Mettling C, Milhiet PE, Costa L, Godefroy C, Pugniere M, Guichou JF, Mesnard JM, Blaise M, Beaumelle B, J Virol, 2023
A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome cExit
Martin M, deVisch A, Boudehen YM, Barthe P, Gutierrez C, Turapov O, Aydogan T, Heriaud L, Gracy J, Neyrolles O, Mukamolova GV, Letourneur F, Cohen-Gonsaud M, Microbiol Spectr, 2023
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins
Agam G, Gebhardt C, Popara M, Machtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hubner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Munoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schroeder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T, Nat Methods, 2023
Structure and mechanics of the human nuclear pore complex basket using correlative AFM-fluorescence superresolution microscopy
Vial A, Costa L, Dosset P, Rosso P, Boutieres G, Faklaris O, Haschke H, Milhiet PE, Doucet CM, Nanoscale, 2023
WASCO: A Wasserstein-based statistical tool to compare conformational ensembles of intrinsically disordered proteins
Gonzalez-Delgado J, Sagar A, Zanon C, Lindorff-Larsen K, Bernado P, Neuvial P, Cortes J, J Mol Biol, 2023
Retinoic Acid and Retinoid X Receptors
Schubert M, Germain P, Cells, 2023
Contributions of 3D chromatin structure to cell-type-specific gene regulation
Schaeffer M, Nollmann M, Curr Opin Genet Dev, 2023
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
Elena-Real CA, Sagar A, Urbanek A, Popovic M, Morato A, Estana A, Fournet A, Doucet C, Lund XL, Shi ZD, Costa L, Thureau A, Allemand F, Swenson RE, Milhiet PE, Crehuet R, Barducci A, Cortes J, Sinnaeve D, Sibille N, Bernado P, Nat Struct Mol Biol, 2023
2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors
Ren XM, Chang RC, Huang Y, Amorim Amato A, Carivenc C, Grimaldi M, Kuo Y, Balaguer P, Bourguet W, Blumberg B, Endocrinology, 2023
Unmasking of the von Willebrand A-domain surface adhesin CglB at bacterial focal adhesions mediates myxobacterial gliding motility
Islam ST, Jolivet NY, Cuzin C, Belgrave AM, My L, Fleuchot B, Faure LM, Mahanta U, Kezzo AA, Saidi F, Sharma G, Fiche JB, Bratton BP, Herrou J, Nollmann M, Shaevitz JW, Durand E, Mignot T, Sci Adv, 2023
An optimized electrotransformation protocol for Lactobacillus jensenii
Fristot E, Bessede T, Camacho Rufino M, Mayonove P, Chang HJ, Zuniga A, Michon AL, Godreuil S, Bonnet J, Cambray G, PLoS One, 2023
Nucleation of Biomolecular Condensates from Finite-Sized Simulations
Li L, Paloni M, Finney AR, Barducci A, Salvalaglio M, J Phys Chem Lett, 2023
Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization
Morichaud Z, Trapani S, Vishwakarma RK, Chaloin L, Lionne C, Lai-Kee-Him J, Bron P, Brodolin K, Nat Commun, 2023
Structures of the arginine-vasopressin and oxytocin receptor signaling complexes
Bous J, Fouillen A, Orcel H, Granier S, Bron P, Mouillac B, Vitam Horm, 2023
Structure-guided mutagenesis of the capsid protein indicates that a nanovirus requires assembled viral particles for systemic infection
Trapani S, Bhat EA, Yvon M, Lai-Kee-Him J, Hoh F, Vernerey MS, Pirolles E, Bonnamy M, Schoehn G, Zeddam JL, Blanc S, Bron P, PLoS Pathog, 2023
Fatty Acid Metabolism in Fungi
Bhat EA, Sajjad N, Bron P, Shah AM, Song Y, Fungal Lipid Biochemistry, 2023
Disruption of influenza virus packaging signals results in various misassembled genome complexes
Girard J, Jakob C, Toews LK, Fuchs J, Pohlmann A, Franzke K, Kolesnikova L, Hess M, Jeney C, Beer M, Bron P, Schwemmle M, Bolte H, J. Virol, 2023