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2023

Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds
Kwong HS, Paloni M, Grandvuillemin L, Sirounian S, Ancelin A, Lai-Kee-Him J, Grimaldi M, Carivenc C, Lancey C, Ragan TJ, Hesketh EL, Balaguer P, Barducci A, Gruszczyk J, Bourguet W, J Mol Biol, 2023
A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation
Valverde JM, Dubra G, Phillips M, Haider A, Elena-Real C, Fournet A, Alghoul E, Chahar D, Andres-Sanchez N, Paloni M, Bernado P, van Mierlo G, Vermeulen M, van den Toorn H, Heck AJR, Constantinou A, Barducci A, Ghosh K, Sibille N, Knipscheer P, Krasinska L, Fisher D, Altelaar M, Nat Commun, 2023
Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins
Malinverni D, Zamuner S, Rebeaud ME, Barducci A, Nillegoda NB, De Los Rios P, Proc Natl Acad Sci U S A, 2023
Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
Alghoul E, Paloni M, Takedachi A, Urbach S, Barducci A, Gaillard PH, Basbous J, Constantinou A, Mol Cell, 2023
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
Elena-Real CA, Sagar A, Urbanek A, Popovic M, Morato A, Estana A, Fournet A, Doucet C, Lund XL, Shi ZD, Costa L, Thureau A, Allemand F, Swenson RE, Milhiet PE, Crehuet R, Barducci A, Cortes J, Sinnaeve D, Sibille N, Bernado P, Nat Struct Mol Biol, 2023
Nucleation of Biomolecular Condensates from Finite-Sized Simulations
Li L, Paloni M, Finney AR, Barducci A, Salvalaglio M, J Phys Chem Lett, 2023
TASEPy: A Python-based package to iteratively solve the inhomogeneous exclusion process
Ciandrini L, Crisostomo RL, Szavitz-Nossan J, SciPost Physics Codebases, 2023
Codebase release 1.1 for TASEPy
Ciandrini L, Crisostomo RL, Szavitz-Nossan J, SciPost Physics Codebases, 2023

Nom & prénom	Organisme	Photos
BARDUCCI Alessandro
BEREZOVSKA Yelyzaveta
BOCCALINI Matteo
CHAAYA Antonella
CIANDRINI Luca
CORPET Vincent
ERBA Davide
FUCHS Philippe
KEISERS Johannes
KHAZAAL Tala
KONIUKOV Georgii
LAVAGNA Enrico
LAZO-PARAVICINI Patricia
YANKAM-PETBUN Dorcasse-Hermine

Resp. Admin.	Didier Debain
	(33) 04 67 41 79 01

Resp.Admin.	Florence Lepage
	(33) 04 67 41 79 04

Assist.Gest.	Marion Boutin
	(33) 04 67 41 79 04

Centre de Biologie Structurale

Dernières publications

The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited

Free-Standing DNA Origami Superlattice to Facilitate Cryo-EM Visualization of Membrane Vesicles

Multiplexed chromatin imaging reveals predominantly pairwise long-range coordination between Drosophila Polycomb genes

Phosphorylation of the F-BAR protein Hof1 drives septin ring splitting in budding yeast

1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors-a PARC project

1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM

Hi-M: A Multiplex Oligopaint FISH Method to Capture Chromatin Conformations In Situ and Accompanying Open-Source Acquisition Software

Emergence of slip-ideal-slip behavior in tip-links serve as force filters of sound in hearing

Increases in cyclin A/Cdk activity and in PP2A-B55 inhibition by FAM122A are key mitosis-inducing events

pyHiM: a new open-source, multi-platform software package for spatial genomics based on multiplexed DNA-FISH imaging

LactoSpanks: A Collection of IPTG Inducible Promoters for the Commensal Lactic Acid Bacteria Lactobacillus gasseri

PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins

An innovative in situAFM system for a soft X-ray spectromicroscopy synchrotron beamline

Critical micellar concentration determination of pure phospholipids and lipid-raft and their mixtures with cholesterol

Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric alphaD pocket

Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds

Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration

The genome of a bunyavirus cannot be defined at the level of the viral particle but only at the scale of the viral population

A single-domain intrabody targeting the follicle-stimulating hormone receptor impacts FSH-induced G protein-dependent signalling

Structure-function relationships in protein homorepeats

3D chromatin interactions involving Drosophila insulators are infrequent but preferential and arise before TADs and transcription

A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation

wTSA-CRAFT: an open-access web server for rapid analysis of thermal shift assay experiments

Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings

Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae

Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria

Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction

The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia-reperfusion injury via mitoprotection

Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies

Membres de l'équipe

Publications

2023

Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds

A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation

Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair

The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity

Nucleation of Biomolecular Condensates from Finite-Sized Simulations

TASEPy: A Python-based package to iteratively solve the inhomogeneous exclusion process

Codebase release 1.1 for TASEPy

2022

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

Viro-fluidics: Real-time analysis of virus production kinetics at the single-cell level

Protein degradation sets the fraction of active ribosomes at vanishing growth

Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR

2021

The diversity of molecular interactions involving intrinsically disordered proteins: A molecular modeling perspective

Arginine multivalency stabilizes protein/RNA condensates

Author Correction: Molecular dissection of amyloid disaggregation by human HSP70

2020

Molecular dissection of amyloid disaggregation by human HSP70

Unraveling Molecular Interactions in Liquid-Liquid Phase Separation of Disordered Proteins by Atomistic Simulations

Rational programming of history-dependent logic in cellular populations

Inferring efficiency of translation initiation and elongation from ribosome profiling

Coevolutionary Analysis of Protein Subfamilies by Sequence Reweighting

2019

Efficient conversion of chemical energy into mechanical work by Hsp70 chaperones

Insights into the activation mechanism of human estrogen-related receptor gamma by environmental endocrine disruptors

Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression

DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes

Aromatic Ring Dynamics, Thermal Activation, and Transient Conformations of a 468 kDa Enzyme by Specific

Structural basis for chemically-induced homodimerization of a single domain antibody

Function, evolution, and structure of J-domain proteins

Driven transport on a flexible polymer with particle recycling: a model inspired by transcription and translation

An equilibrium model for ribosome competition

Exclusion process subject to conformational size changes

Accurate measures of translation efficiency and traffic using ribosome profiling

Coevolutionary Analysis of Protein Sequences for Molecular Modeling

2018

Emerging fields in chaperone proteins: a French workshop

Lipid tempering simulation of model biological membranes on parallel platforms

Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins

2017

Catch bond drives stator mechanosensitivity in the bacterial flagellar motor

Prion protein beta2-alpha2 loop conformational landscape

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and co-evolutionary sequence analysis