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Centre de Biologie Structurale

Actualités

Séminaires

19 Jui

Mini Symposium EM 19 Jui 2025 09:00 to 12:30
19 Jui

CBS Invited Talk: " "Exploring Albumin Versatility: From Biotherapeutics to Biotech Applications", Sofia De Felice (Department of Biology, University of Padua, Italy). 19 Jui 2025 14:00 to 15:00
Host: Gilles Labesse
20 Jui

Young CBS Researchers Meeting 20 Jui 2025 16:00 to 17:00

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Dernières publications

Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
Lleres D, Gizzi AC, Nollmann M, Curr Opin Cell Biol, 2025
Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET
Bonhomme L, Bilgen E, Clerte C, Pin JP, Rondard P, Margeat E, Lamb DC, Quast RB, J Am Chem Soc, 2025
Editorial overview: Emerging perspectives in genome architecture and gene regulation
Nollmann M, Hansen AS, Curr Opin Genet Dev, 2025
Molecular Assemblies of Amphiphilic Oligothiophenes at the Air-Water Interface
Idriss H, Albert S, Bae C, Poyac L, Gerbier P, Bonhomme O, Lai-Kee-Him J, Ancelin A, Richeter S, Sen I, Leo K, Biance AL, Clement S, Langmuir, 2025
Structural and Functional Characterization of the 28kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti
Mouhand A, Pissarra J, Barthe P, Roumestand C, Delbecq S, Proteins, 2025
Single-stranded DNA drives sigma subunit loading onto mycobacterial RNA polymerase to unlock initiation-competent conformations
Vishwakarma RK, Marechal N, Morichaud Z, Blaise M, Margeat E, Brodolin K, Nucleic Acids Res, 2025
Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations
Boccalini M, Berezovska Y, Bussi G, Paloni M, Barducci A, Proc Natl Acad Sci U S A, 2025
Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli
Droghetti R, Fuchs P, Iuliani I, Firmano V, Tallarico G, Calabrese L, Grilli J, Sclavi B, Ciandrini L, Cosentino Lagomarsino M, Nat Commun, 2025
Structure of the turnip yellows virus particles
Lai-Kee-Him J, Trapani S, Boissinot S, Reinbold C, Fallet C, Ancelin A, Lecorre F, Hoh F, Ziegler-Graff V, Brault V, Bron P, Virology, 2025
K_DSAXS: A Tool for Analyzing Binding Equilibria With SAXS Data Using Explicit Models
Gomes T, Ruiz L, Martin-Malpartida P, Bernado P, Baptista AM, Macias MJ, Cordeiro TN, J Mol Biol, 2025
Structure-guided insights into the biology of fungal effectors
Le Naour-Vernet M, Lahfa M, Maidment JHR, Padilla A, Roumestand C, deGuillen K, Kroj T, Cesari S, New Phytol, 2025
Understanding the Relationship between Pressure and Temperature Unfolding of Proteins
Roumestand C, Dudas E, Puglisi R, Calio A, Barthe P, Temussi PA, Pastore A, JACS Au, 2025
GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation
Gorgues L, Smokvarska M, Mercier C, Igisch CP, Crabos A, Dongois A, Bayle V, Fiche JB, Nacry P, Nollmann M, Jaillais Y, Martiniere A, EMBO Rep, 2025
A mechanism for ligand-dependent activation of AHR
Guesdon A, Bourguet W, Trends Pharmacol Sci, 2025
AFflecto: A web server to generate conformational ensembles of flexible proteins from AlphaFold models
Pajkos M, Clerc I, Zanon C, Bernado P, Cortes J, J Mol Biol, 2025
Binding-Site Switch for Protein Kinase CK2 Inhibitors
Grenier D, Gelin M, Yang Y, Mularoni A, Guichou JF, Delcros JG, Krimm I, ChemMedChem, 2025
A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target
Carivenc C, Laconde G, Blanc P, Amblard M, Bourguet W, Delfosse V, Acta Crystallogr F Struct Biol Commun, 2025
An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice
Wang X, Zhang G, Bian Z, Chow V, Grimaldi M, Carivenc C, Sirounian S, Li H, Sladekova L, Mott S, Luperi Y, Gong Y, Costello C, Li L, Jachimowicz M, Guo M, Hu S, Wilson D, Balaguer P, Bourguet W, Mani S, Bonati L, Peng H, March J, Wang H, Wang S, Krause HM, Liu J, Nat Commun, 2025
APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus
Kaplan E, Chaloin L, Guichou JF, Berrou K, Rahimova R, Labesse G, Lionne C, ChemMedChem, 2025
Cryo-EM structure and regulation of human NAD kinase
Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G, Sci Adv, 2025
Binding-site switch of Protein Kinase CK2 inhibitors
Krimm I, Grenier D, Gelin M, Yang Cbs Cnrs Fr Y, Mularoni A, Guichou JF, Delcros JG, ChemMedChem, 2025
Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides
Pradeau-Phelut L, Alves S, Le Tareau L, Larralde C, Bernard E, Schirmer C, Lai-Kee-Him J, Lepvrier E, Bron P, Delamarche C, Garnier C, Anal Chem, 2025
Microbes Saving Lives and Reducing Suffering
Timmis K, Karahan ZC, Ramos JL, Koren O, Perez-Cobas AE, Steward K, de Lorenzo V, Caselli E, Douglas M, Schwab C, Rivero V, Giraldo R, Garmendia J, Turner RJ, Perlmutter J, Borrero de Acuna JM, Nikel PI, Bonnet J, Sessitsch A, Timmis JK, Pruzzo C, Prieto MA, Isazadeh S, Huang WE, Clarke G, Ercolini D, Haggblom M, Microb Biotechnol, 2025
Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues
Elena-Real CA, Urbanek A, Sagar A, Mohanty P, Levy G, Morato A, Fournet A, Allemand F, Sibille N, Mittal J, Sinnaeve D, Bernado P, Chemistry, 2024
Measuring Bacterial Flagellar Motor Dynamics via a Bead Assay
Hoffmann WH, Biquet-Bisquert A, Pedaci F, Nord AL, Methods Mol Biol, 2024
Determining the Relative Affinity of ORPs for Lipid Ligands Using Fluorescence and Thermal Shift Assays
Delfosse V, Drin G, Methods Mol Biol, 2024
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants
le Maire A, Bourguet W, Annu Rev Pharmacol Toxicol, 2024
Self-Assembled Peptide-Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells
Moro S, Omrani M, Erbek S, Jourdan M, Vandekerckhove CI, Nogier C, Vanwonterghem L, Molina MC, Bernado P, Thureau A, Coll JL, Renaudet O, Le Guevel X, Faure V, Small Sci, 2024
Structural Insights Into Thyroid Hormone Receptors
Tambones I, le Maire A, Endocrinology, 2024
Structural basis of orientated asymmetry in a mGlu heterodimer
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J, Nat Commun, 2024

Voir toutes les publications

Technologies

Microscopies de fluorescence de molécules uniques

Microscope TIRF avec excitation alternée pour suivi de particules uniques et spFRET

Microscope confocal avec excitation alternée pulsée (PIE/nsALEX) et detection TCSPC résolue en temps et en polarisation, pour mesures de FRET sur molécules uniques

Microscopie biphotonique de corrélation de fluorescence FCS/ FCCS/ N&B analysis

Microscopies à force atomique

Microscopie à force atomique haute vitesse

Microscope développé en collaboration avec le Professeur Toshio Ando, maintenant commercialisé par RIBM.

Microscopes multimode

2 Microscopes Multimode équipés d’un contrôleur Nanoscope® 3a ou 8 (Nano-Bruker, ). Possibilité de mode "Peak Force Tapping".

AFM JPK couplé à la microscopie de fluorescence super résolue (SIngle Molecule Localization Microscopy)

Microscope JPK (Berlin, Allemagne) monté sur un microscope inversé Zeiss équipé pour la microscopie de fluorescence super résolue.

Les équipes du CBS

Structure, dynamique et fonctions des biomolécules par RMN

Christian Roumestand et Nathalie Declerck
Structure et fonction de protéines hautement flexibles

Pau Bernadó et Nathalie Sibille
Biologie structurale multi-échelles (BSME)

Patrick Bron
Atelier de Biologie-Chimie-Informatique Structurale

Gilles Labesse
Les récepteurs nucléaires, intégrateurs de signaux endogènes et environnementaux

William Bourguet et Albane Le Maire
Modélisation moléculaire multi-échelle

Alessandro Barducci
Mécanismes de la ségrégation de l’ADN et du remodelage

Marcelo Nollmann
Physique et mécanique des systèmes biologiques

Manouk Abkarian et Francesco Pedaci
Biophysique Intégrative des Membranes

Pierre-Emmanuel Milhiet et Emmanuel Margeat
Biologie Synthétique

Jérôme Bonnet et Martin Cohen-Gonsaud
Modélisation moléculaire multi-échelle

Alessandro Barducci
Structure du chromosome et recombinaison en méiose

Thomas Robert
Génomique fonctionnelle et synthétique

Guillaume Cambray
Structure et fonction du récepteur AhR

Jakub Gruszczyk

Resp. Admin.	Didier Debain
	(33) 04 67 41 79 01

Resp.Admin.	Florence Lepage
	(33) 04 67 41 79 04

Assist.Gest.	Marion Boutin
	(33) 04 67 41 79 04

Centre de Biologie Structurale

Dernières publications

Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives

Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET

Editorial overview: Emerging perspectives in genome architecture and gene regulation

Molecular Assemblies of Amphiphilic Oligothiophenes at the Air-Water Interface

Structural and Functional Characterization of the 28kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti

Single-stranded DNA drives sigma subunit loading onto mycobacterial RNA polymerase to unlock initiation-competent conformations

Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations

Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli

Structure of the turnip yellows virus particles

KDSAXS: A Tool for Analyzing Binding Equilibria With SAXS Data Using Explicit Models

Structure-guided insights into the biology of fungal effectors

Understanding the Relationship between Pressure and Temperature Unfolding of Proteins

GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation

A mechanism for ligand-dependent activation of AHR

AFflecto: A web server to generate conformational ensembles of flexible proteins from AlphaFold models

Binding-Site Switch for Protein Kinase CK2 Inhibitors

A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target

An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice

APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus

Cryo-EM structure and regulation of human NAD kinase

Binding-site switch of Protein Kinase CK2 inhibitors

Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides

Microbes Saving Lives and Reducing Suffering

Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues

Measuring Bacterial Flagellar Motor Dynamics via a Bead Assay

Determining the Relative Affinity of ORPs for Lipid Ligands Using Fluorescence and Thermal Shift Assays

What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants

Self-Assembled Peptide-Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells

Structural Insights Into Thyroid Hormone Receptors

Structural basis of orientated asymmetry in a mGlu heterodimer

Technologies

Microscopies de fluorescence de molécules uniques

Microscopies à force atomique

Les équipes du CBS

Postdoctoral position – Team Integrative Biophysics of Membranes

Structure, dynamique et fonctions des biomolécules par RMN

Structure et fonction de protéines hautement flexibles

Biologie structurale multi-échelles (BSME)

Atelier de Biologie-Chimie-Informatique Structurale

Les récepteurs nucléaires, intégrateurs de signaux endogènes et environnementaux

Mécanismes de la ségrégation de l’ADN et du remodelage

Physique et mécanique des systèmes biologiques

Biophysique Intégrative des Membranes

Modélisation moléculaire multi-échelle

Biologie Synthétique

Structure du chromosome et recombinaison en méiose

Génomique fonctionnelle et synthétique

Structure et fonction du récepteur AhR

Postdoctoral position – Team Integrative Biophysics of Membranes

Connexion

K_DSAXS: A Tool for Analyzing Binding Equilibria With SAXS Data Using Explicit Models