Centre de Biologie Structurale

News

Seminars

05 Aug

Conseil de Direction 05 Aug 2025 02:00 PM to 04:00 PM
02 Sep

Conseil Labo 02 Sep 2025 02:00 PM to 02:30 PM
02 Sep

Conseil de Direction 02 Sep 2025 02:00 PM to 04:00 PM

05 Aug - 02 Sep
12 Sep - 26 Sep
07 Oct - 10 Oct

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Latest publications

In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque
Drobnic T, Cohen EJ, Calcraft T, Alzheimer M, Froschauer K, Svensson S, Hoffman WH, Singh N, Garg SG, Henderson LD, Umrekar TR, Nans A, Ribardo D, Pedaci F, Nord AL, Hochberg GKA, Hendrixson DR, Sharma CM, Rosenthal PB, Beeby M, Nat Microbiol, 2025
Sequence- and Docking-Site-Dependent Contributions to Multi-Site Phosphorylation of an Intrinsically Disordered MAPK Substrate
Orand T, Delaforge E, Chenal M, Tengo M, Herrmann T, Cortes J, Bernado P, Jensen MR, Adv Sci (Weinh), 2025
The dependence of the amino acid backbone conformation on the translated synonymous codon is not statistically significant
Gonzalez-Delgado J, Mier P, Bernado P, Neuvial P, Cortes J, Proc Natl Acad Sci U S A, 2025
A coiled-coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor
Couston J, Feuillard J, Ancelin A, Lai-Kee-Him J, Brodolin K, Chalut C, Gourdon P, Blaise M, FEBS Lett, 2025
Lipids modulate the dynamics of GPCR:beta-arrestin interaction
Gomes AAS, Di Michele M, Roessner RA, Damian M, Bisch PM, Sibille N, Louet M, Baneres JL, Floquet N, Nat Commun, 2025
Picomolar bivalent inhibitors of protein kinase CK2 active against beta-coronavirus replication
Grenier D, Lopez Molina DS, Gelin M, Mularoni A, Guichou JF, Delcros JG, Martinasso C, Yang Y, Ahnou N, Pawlotsky JM, Ahmed-Belkacem A, Krimm I, Eur J Med Chem, 2025
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
Lleres D, Gizzi AC, Nollmann M, Curr Opin Cell Biol, 2025
Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET
Bonhomme L, Bilgen E, Clerte C, Pin JP, Rondard P, Margeat E, Lamb DC, Quast RB, J Am Chem Soc, 2025
Editorial overview: Emerging perspectives in genome architecture and gene regulation
Nollmann M, Hansen AS, Curr Opin Genet Dev, 2025
Structural and Functional Characterization of the 28kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti
Mouhand A, Pissarra J, Barthe P, Roumestand C, Delbecq S, Proteins, 2025
Molecular Assemblies of Amphiphilic Oligothiophenes at the Air-Water Interface
Idriss H, Albert S, Bae C, Poyac L, Gerbier P, Bonhomme O, Lai-Kee-Him J, Ancelin A, Richeter S, Sen I, Leo K, Biance AL, Clement S, Langmuir, 2025
Single-stranded DNA drives sigma subunit loading onto mycobacterial RNA polymerase to unlock initiation-competent conformations
Vishwakarma RK, Marechal N, Morichaud Z, Blaise M, Margeat E, Brodolin K, Nucleic Acids Res, 2025
Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations
Boccalini M, Berezovska Y, Bussi G, Paloni M, Barducci A, Proc Natl Acad Sci U S A, 2025
Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli
Droghetti R, Fuchs P, Iuliani I, Firmano V, Tallarico G, Calabrese L, Grilli J, Sclavi B, Ciandrini L, Cosentino Lagomarsino M, Nat Commun, 2025
Structure of the turnip yellows virus particles
Lai-Kee-Him J, Trapani S, Boissinot S, Reinbold C, Fallet C, Ancelin A, Lecorre F, Hoh F, Ziegler-Graff V, Brault V, Bron P, Virology, 2025
Structure-guided insights into the biology of fungal effectors
Le Naour-Vernet M, Lahfa M, Maidment JHR, Padilla A, Roumestand C, deGuillen K, Kroj T, Cesari S, New Phytol, 2025
K_DSAXS: A Tool for Analyzing Binding Equilibria With SAXS Data Using Explicit Models
Gomes T, Ruiz L, Martin-Malpartida P, Bernado P, Baptista AM, Macias MJ, Cordeiro TN, J Mol Biol, 2025
Understanding the Relationship between Pressure and Temperature Unfolding of Proteins
Roumestand C, Dudas E, Puglisi R, Calio A, Barthe P, Temussi PA, Pastore A, JACS Au, 2025
GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation
Gorgues L, Smokvarska M, Mercier C, Igisch CP, Crabos A, Dongois A, Bayle V, Fiche JB, Nacry P, Nollmann M, Jaillais Y, Martiniere A, EMBO Rep, 2025
A mechanism for ligand-dependent activation of AHR
Guesdon A, Bourguet W, Trends Pharmacol Sci, 2025
AFflecto: A web server to generate conformational ensembles of flexible proteins from AlphaFold models
Pajkos M, Clerc I, Zanon C, Bernado P, Cortes J, J Mol Biol, 2025
Binding-Site Switch for Protein Kinase CK2 Inhibitors
Grenier D, Gelin M, Yang Y, Mularoni A, Guichou JF, Delcros JG, Krimm I, ChemMedChem, 2025
A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target
Carivenc C, Laconde G, Blanc P, Amblard M, Bourguet W, Delfosse V, Acta Crystallogr F Struct Biol Commun, 2025
An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice
Wang X, Zhang G, Bian Z, Chow V, Grimaldi M, Carivenc C, Sirounian S, Li H, Sladekova L, Mott S, Luperi Y, Gong Y, Costello C, Li L, Jachimowicz M, Guo M, Hu S, Wilson D, Balaguer P, Bourguet W, Mani S, Bonati L, Peng H, March J, Wang H, Wang S, Krause HM, Liu J, Nat Commun, 2025
APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus
Kaplan E, Chaloin L, Guichou JF, Berrou K, Rahimova R, Labesse G, Lionne C, ChemMedChem, 2025
Cryo-EM structure and regulation of human NAD kinase
Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G, Sci Adv, 2025
Binding-site switch of Protein Kinase CK2 inhibitors
Krimm I, Grenier D, Gelin M, Yang Cbs Cnrs Fr Y, Mularoni A, Guichou JF, Delcros JG, ChemMedChem, 2025
Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides
Pradeau-Phelut L, Alves S, Le Tareau L, Larralde C, Bernard E, Schirmer C, Lai-Kee-Him J, Lepvrier E, Bron P, Delamarche C, Garnier C, Anal Chem, 2025
Microbes Saving Lives and Reducing Suffering
Timmis K, Karahan ZC, Ramos JL, Koren O, Perez-Cobas AE, Steward K, de Lorenzo V, Caselli E, Douglas M, Schwab C, Rivero V, Giraldo R, Garmendia J, Turner RJ, Perlmutter J, Borrero de Acuna JM, Nikel PI, Bonnet J, Sessitsch A, Timmis JK, Pruzzo C, Prieto MA, Isazadeh S, Huang WE, Clarke G, Ercolini D, Haggblom M, Microb Biotechnol, 2025
Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues
Elena-Real CA, Urbanek A, Sagar A, Mohanty P, Levy G, Morato A, Fournet A, Allemand F, Sibille N, Mittal J, Sinnaeve D, Bernado P, Chemistry, 2024

View all publications

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*Platform*	Protein crystallisation and structure determination facilities - FRISBI
*Technical managers*	François Hoh , Muriel Gelin
*Scientific manager*	Vanessa Delfosse
*Permanent staff*	François Hoh, Jean-François Guichou, Gilles Labesse, Muriel Gelin, Jean-François Guichou, Albane le Maire, William Bourguet
Automated crystallization screening and optimization using hanging and sitting drop set up at two temperatures (20 deg and 4 deg). Diffraction using synchrotron beamlines and structure elucidation.
*Comments*	For data collection, The CBS has regularly access to several synchrotron like ESRF (Grenoble, FR), Soleil (Gif-sur-Yvette, FR), SLS (Villigen,CH) and ALBA (Barcelona, Spain).

Services

Crystallisation screening and crystallisation conditions optimization		Automated visualization of protein crystallization drops		Automated pippeting and liquid handling		Ligand screening
Read more ...		Read more ...		Read more ...		Read more ...

CBS Teams

Structure, Dynamics and Function of biomolecules by NMR

Christian Roumestand and Nathalie Declerck
Structure and function of highly flexible proteins

Pau Bernadó and Nathalie Sibille
Multi-scale structural biology

Patrick Bron
ABCIS

Gilles Labesse
Nuclear Receptors as Integrators of Endogenous and Environmental Signals

William Bourguet and Albane Le Maire
Multiscale Biomolecular Modeling

Alessandro Barducci
Mechanisms of DNA Segregation and Remodelling

Marcelo Nollmann
Physics and mechanics of biological systems

Manouk Abkarian and Francesco Pedaci
Integrative Biophysics of Membranes

Pierre-Emmanuel Milhiet and Emmanuel Margeat
Synthetic Biology

Jérôme Bonnet and Martin Cohen-Gonsaud
Multiscale Biomolecular Modeling

Alessandro Barducci
Chromosome structure and homologous recombination in meiosis

Thomas Robert
Functional and synthetic genomics

Guillaume Cambray
Structure and function of the aryl hydrocarbon receptor

Jakub Gruszczyk

Admin.Resp.	Florence Lepage
	(33) 04 67 41 79 04

Admin.Resp.	Didier Debain
	(33) 04 67 41 79 01

Manager.Assist.	Marion Boutin
	(33) 04 67 41 79 04

Centre de Biologie Structurale

Latest publications

In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque

Sequence- and Docking-Site-Dependent Contributions to Multi-Site Phosphorylation of an Intrinsically Disordered MAPK Substrate

The dependence of the amino acid backbone conformation on the translated synonymous codon is not statistically significant

A coiled-coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

Lipids modulate the dynamics of GPCR:beta-arrestin interaction

Picomolar bivalent inhibitors of protein kinase CK2 active against beta-coronavirus replication

Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives

Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET

Editorial overview: Emerging perspectives in genome architecture and gene regulation

Structural and Functional Characterization of the 28kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti

Molecular Assemblies of Amphiphilic Oligothiophenes at the Air-Water Interface

Single-stranded DNA drives sigma subunit loading onto mycobacterial RNA polymerase to unlock initiation-competent conformations

Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations

Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli

Structure of the turnip yellows virus particles

Structure-guided insights into the biology of fungal effectors

KDSAXS: A Tool for Analyzing Binding Equilibria With SAXS Data Using Explicit Models

Understanding the Relationship between Pressure and Temperature Unfolding of Proteins

GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation

A mechanism for ligand-dependent activation of AHR

AFflecto: A web server to generate conformational ensembles of flexible proteins from AlphaFold models

Binding-Site Switch for Protein Kinase CK2 Inhibitors

A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target

An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice

APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus

Cryo-EM structure and regulation of human NAD kinase

Binding-site switch of Protein Kinase CK2 inhibitors

Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides

Microbes Saving Lives and Reducing Suffering

Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues

xray

Protein crystallisation and structure determination facilities - FRISBI

CBS Teams

Structure, Dynamics and Function of biomolecules by NMR

Structure and function of highly flexible proteins

Multi-scale structural biology

ABCIS

Nuclear Receptors as Integrators of Endogenous and Environmental Signals

Mechanisms of DNA Segregation and Remodelling

Physics and mechanics of biological systems

Integrative Biophysics of Membranes

Multiscale Biomolecular Modeling

Synthetic Biology

Chromosome structure and homologous recombination in meiosis

Functional and synthetic genomics

Structure and function of the aryl hydrocarbon receptor

Postdoctoral position – Team Integrative Biophysics of Membranes

Postdoctoral position – Team Integrative Biophysics of Membranes

Connexion

K_DSAXS: A Tool for Analyzing Binding Equilibria With SAXS Data Using Explicit Models