PIBBS publications

 

 

Pôle RMN

Lahfa M, Padilla A, de Guillen K, Pissarra J, Raji M, Cesari S, Kroj T, Gladieux P, Roumestand C, Barthe P. 1H, 13C, 15 N backbone and side-chain NMR assignments for three MAX effectors from Magnaporthe oryzae. Biomol NMR Assign 2022 doi:10.1007/s12104-022-10095-2

Chaves-Arquero B, Martínez-Lumbreras S, Sibille N, Camero S, Bernadó P, Jiménez MÁ, Zorrilla S, Pérez-Cañadillas JM. eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly Int J Mol Sci 2022 doi:10.3389/fmolb.2022.986121

Caliò A, Dubois C, Fontanay S, Koza MM, Hoh F, Roumestand C, Oger P, Peters J Unravelling the Adaptation Mechanisms to High Pressure in Proteins. Int J Mol Sci 2022 doi:10.3390/ijms23158469

Poignavent V, Hoh F, Terral G, Yang Y, Gillet FX, Kim JH, Allemand F, Lacombe E, Brugidou C, Cianferani S, Déméné H, Vignols F A Flexible and Original Architecture of Two Unrelated Zinc Fingers Underlies the Role of the Multitask P1 in RYMV Spread J Mol Biol 2022 doi:10.1016/j.jmb.2022.167715

Momin AA, Mendes T, Barthe P, Faure C, Hong S, Yu P, Kadaré G, Jaremko M, Girault JA, Jaremko ?, Arold ST. PYK2 senses calcium through a disordered dimerization and calmodulin-binding element. Commun Biol. 2022 doi:10.1038/s42003-022-03760-8

Cesari S, Xi Y, Declerck N, Chalvon V, Mammri L, Pugnière M, Henriquet C, de Guillen K, Chochois V, Padilla A, Kroj T New recognition specificity in a plant immune receptor by molecular engineering of its integrated domain Nat Commun 2022 doi:10.1038/s41467-022-29196-6

Xi Y, Chalvon V, Padilla A, Cesari S, Kroj T. The activity of the RGA5 sensor NLR from rice requires binding of its integrated HMA domain to effectors but not HMA domain self-interaction Mol Plant Pathogens 2022 doi:10.1111/mpp.13236.

Dubois C, Planelles-Herrero VJ, Tillatte-Tripodi C, Delbecq S, Mammri L, Sirkia EM, Ropars V, Roumestand C, Barthe P. Pressure and Chemical Unfolding of an ?-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1 International Journal of Molecular Sciences 2021 doi:10.3390/ijms22073597

Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R. Molecular insights into the biased signaling mechanism of the ?-opioid receptor Molecular Cell 2021 doi:10.1016/j.molcel.2021.07.033

Skvarnavi?ius G, Toleikis Z, Michailovien? V, Roumestand C, Matulis D, Petrauskas V Protein Ligand Binding Volume Determined from a Single 2D NMR Spectrum with Increasing Pressure The Journal of Physical Chemistry B 2021 doi:10.1021/acs.jpcb.1c02917

Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Déméné H, Granier S, Bron P, Mouillac B. Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex Science Advances 2021 doi:10.1126/sciadv.abg5628

Van Deuren V, Yang YS, de Guillen K, Dubois C, Royer CA, Roumestand C, Barthe P Comparative Assessment of NMR Probes for the Experimental Description of Protein Folding Pathways with High-Pressure NMR Biology 2021 doi:10.3390/biology10070656

Senicourt L, le Maire A, Allemand F, Carvalho JE, Guee L, Germain P, Schubert M, Bernadó P, Bourguet W, Sibille N. Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR) Journal of Molecular Biology 2021 doi:10.1016/j.jmb.2021.166899

Labbé JC, Vigneron S, Méchali F, Robert P, Roque S, Genoud C, Goguet-Rubio P, Barthe P, Labesse G, Cohen-Gonsaud M, Castro A, Lorca T The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop Nature Communications 2021 doi:10.1038/s41467-021-23657-0

Saotome T, Doret M, Kulkarni M, Yang YS, Barthe P, Kuroda Y, Roumestand C Folding of the Ig-Like Domain of the Dengue Virus Envelope Protein Analyzed by High-Hydrostatic-Pressure NMR at a Residue-Level Resolution Biomolecules, 2019,9:8 PubMed Id 31357538

Yang Y, Poignavent V, Gillet FX, Vignols F, Demene H NMR chemical shift backbone assignment of the viral protein P1 encoded by the African Rice Yellow Mottle Virus Biomol NMR Assign 2019, 13 (2):345-348 PubMed Id 31346897

Gaillard S, Das S, Djibo M, Raviglione D, Roumestand C, Legrand B, Inguimbert N Towards the total synthesis of trichormamide A, a cyclic undecapeptide Tetrahedron Letters 2018,59(41):3713-3718

Guca E, Nagy GN, Hajdu F, Marton L, Izrael R, Hoh F, Yang Y, Vial H, Vertessy BG, Guichou JF, Cerdan R Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis Sci Rep 2018, 8:1 PubMed Id 30046154

Guo L, Cesari S, deGuillen K, Chalvon V, Mammri L, Ma M, Meusnier I, Bonnot F, Padilla A, Peng YL, Liu J, Kroj T Specific recognition of two MAX effectors by integrated HMA domains in plant immune receptors involves distinct binding surfaces Proc Natl Acad Sci USA 2018, 115(45): 11637-11642 PubMed Id 30355769

Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jager D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts J Nucl Med 2018, 59(9): 1423-1429 PubMed Id 29626120

Aldrian G, Vaissiere A, Konate K, Seisel Q, Vives E, Fernandez F, Viguier V, Genevois C, Couillaud F, Demene H, Aggad D, Covinhes A, Barrere-Lemaire S, Deshayes S, Boisguerin P PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo J Control Release 2017,256: 79-91 PubMed Id 28411182

Ortiz D, deGuillen K, Cesari S, Chalvon V, Gracy J, Padilla A, Kroj T Recognition of the Magnaporthe oryzae effector AVR-Pia by the decoy domain of the rice NLR immune receptor RGA5, Plant Cell 2017, 29(1): 156-168 PubMed Id 28087830


Sagnol S, Marchal S, Yang Y, Allemand F, de Stanta Barba P Epithelial Splicing Regulatory Protein 1 (ESRP1) is a new regulator of stomach smooth muscle development and plasticity Dev Biol 2016, 414 (2):207-18 PubMed Id 27108394


Toleikis Z, Sirotkin VA, Skvarnavicius G, SmirnovienÄ— J, Roumestand C, Matulis D, Petrauskas V Volume of Hsp90 Protein-Ligand Binding Determined by Fluorescent Pressure Shift Assay, Densitometry, and NMR J Phys Chem B 2016, 120(37):9903-12 PubMed Id 27571383

deGuillen K, Ortiz-Vallejo D, Gracy J, Fournier E, Kroj T, Padilla A Structure Analysis Uncovers a Highly Diverse but Structurally Conserved Effector Family in Phytopathogenic Fungi PLoS Pathog 2015, 11(10): e1005228 PubMed Id 26506000


Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Demene H, Granier S Propagation of conformational changes during μ-opioid receptor activation Nature 2015, 524 (7565): 375-8 PubMed Id 26245377


Turapov O, Loraine J, Jenkins CH, Barthe P, McFeely D, Forti F, Ghisotti D, Hesek D, Lee M, Bottrill AR, Vollmer W, Mobashery S, Cohen-Gonsaud M, Mukamolova GV The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth Open Biol 2015, 5:7 PubMed Id 26136255

De Biasio A, Ibanez de Opakua A, Cordeiro TN, Villate M, Merino N, Sibille N, Lelli M, Diercks T, Bernado P, Blanco FJ p15(PAF) Is an Intrinsically Disordered Protein with Nonrandom Structural Preferences at Sites of Interaction with Other Proteins Biophys J 2014, 106 ( 4): 865-74 PubMed Id 24559989


Yang Y, Allemand F, Guca E, Vallone B, Delbecq S, Roumestand C (1)H, (15)N and (13)C Backbone resonance assignments of murine met-neuroglobin, free and in complex with cyanide Biomol NMR Assign 2014, PubMed Id 24830543

Yang YS, Fernandez B, Lagorce A, Aloin V, deGuillen KM, Boyer JB, Dedieu A, Confalonieri F, Armengaud J, Roumestand CPrioritizing targets for structural biology through the lens of proteomics: The archaeal protein TGAM_1934 from Thermococcus gammatolerans Proteomics 2014, 9(1):153-6 PubMed Id 25359407



 

 

Pôle Microscopie Electronique

Vincent M, Simon L, Brabet P, Legrand P, Dorandeu C, Him JLK, Durand T, Crauste C, Begu S. Formulation and evaluation of SNEDDS loaded with original lipophenol for the oral route to prevent dry AMPD and Stragardt's disease Pharmaceutics 2022 doi:10.3390/pharmaceutics14051029

Walter P, Mechaly A, Bous J, Haouz A, England P, Lai-Kee-Him J, Ancelin A, Hoos S, Baron B, Trapani S, Bron P, Labesse G, Munier-Lehmann H. Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target. Febs J 2022 doi:10.1111/febs.16393

Saridakis E, Vishwakarma R, Lai-Kee-Him J, Martin K, Simon I, Cohen-Gonsaud M, Coste F, Bron P, Margeat E, Boudvillain M. Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism Commun Biol. 2022 doi:10.1038/s42003-022-03069-6

Bous J, Fouillen A, Orcel H, Trapani S, Cong X, Fontanel S, Saint-Paul J, Lai-Kee-Him J, Urbach S, Sibille N, Sounier R, Granier S, Mouillac B, Bron P Structure of the vasopressin hormone-V2 receptor-?-arrestin1 ternary complex Sci Adv 2022 doi:10.1126/sciadv.abo7761

Ibanes S, El-Alaoui F, Lai-Kee-Him J, Cazevieille C, Hoh F, Lyonnais S, Bron P, Cipelletti L, Picas L, Piatti S. The Syp1/FCHo2 protein induces septin filament bundling through its intrinsically disordered domain. 2022 doi:10.1016/j.celrep.2022.111765

Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Déméné H, Granier S, Bron P, Mouillac B. Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex Science Advances 2021 doi:10.1126/sciadv.abg5628

Aissaoui N, Lai-Kee-Him J, Mills A, Declerck N, Morichaud Z, Brodolin K, Baconnais S, Le Cam E, Charbonnier JB, Sounier R, Granier S, Ropars V, Bron P, Bellot G. Modular Imaging Scaffold for Single-Particle Electron Microscopy ACS Nano 2021 doi:10.1021/acsnano.0c05113

Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Banères JL, Malhaire F, Berto L, Dumazer A, Font-Ingles J, Gómez-Santacana X, Catena J, Kniazeff J, Goudet C, Llebaria A, Pin JP, Vinothkumar KR, Lebon G. Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations Cell Reports 2021 doi:10.1016/j.celrep.2021.109648

Rozier P, Maumus M, Maria ATJ, Toupet K, Lai-Kee-Him J, Jorgensen C, Guilpain P, Noël D. Mesenchymal stromal cells-derived extracellular vesicles alleviate systemic sclerosis via miR-29a-3p Journal of Autoimmunity 2021 doi:10.1016/j.jaut.2021.102660

Le Saux, A, Aarrass, H., Lai-Kee-Him J., Bron, P., Armengaud, J., Miotello, G., Bertrand-Michel J., Dubois, E., George, S., Faklaris, O., Devoisselle, JM, Legrand P., Chopineau, J., Morille, M. Post-production modifications of murine mesenchymal stem cell (mMSC) derived extracellular vesicles (EVs) and impact on their cellular interaction Biomaterials 2020 doi:10.1016/j.biomaterials.2019.119675

Jenni S, Salgado EN, Herrmann T, Li Z, Grant T, Grigorieff N, Trapani S, Estrozi LF, Harrison SC In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase J Mol Biol 2019, 431, (17): 3124-3138 PubMed Id 31233764

Kebe NM, Samanta K, Singh P, Lai-Kee-Him J, Apicella V, Payrot N, Lauraire N, Legrand B, Lisowski V, Mbang-Benet DE, Pages M, Bastien P, Kajava AV, Bron P, Hernandez JF, Coux O The HslV Protease from Leishmania major and Its Activation by C-terminal HslU Peptides. , Int J Mol Sci 2019 20: 5 PubMed Id 30813632


Rascol E, Daurat M, Da Silva A, Maynadier M, Dorandeu C, Charnay C, Garcia M, Lai-Kee-Him J, Bron P, Auffan M, Liu W, Angeletti B, Devoisselle JM, Guari Y, Gary-Bobo M, Chopineau J Biological Fate of Fea‚ƒOa‚„ Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry, Nanomaterials (Basel), 2017, 7:7, PubMed Id 28665317

Dairi S, Madani K, Aoun M, Him JL, Bron P, Lauret C, Cristol JP, Carbonneau MA Antioxidative Properties and Ability of Phenolic Compounds of Myrtus communis Leaves to Counteract In Vitro LDL and Phospholipid Aqueous Dispersion Oxidation J Food Sci 2014, 79(7): C1260-70 PubMed Id 24962212



 

 

Pôle Cristallo/conception de drogues

Lambey P, Otun O, Cong X, Hoh F, Brunel L, Verdié P, Grison CM, Peysson F, Jeannot S, Durroux T, Bechara C, Granier S, Leyrat C. Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins eLife 2022 doi:10.7554/eLife.72555

Jublot D, Cavaillès P, Kamche S, Francisco D, Fontinha D, Prudêncio M, Guichou JF, Labesse G, Sereno D, Loeuillet C. A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti- Toxoplasma and Anti- Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice Int J Mol Sci 2022 doi:10.3390/ijms23063254

Poignavent V, Hoh F, Terral G, Yang Y, Gillet FX, Kim JH, Allemand F, Lacombe E, Brugidou C, Cianferani S, Déméné H, Vignols F A Flexible and Original Architecture of Two Unrelated Zinc Fingers Underlies the Role of the Multitask P1 in RYMV Spread J Mol Biol 2022 doi:10.1016/j.jmb.2022.167715

Liberelle M, Toulotte F, Renault N, Gelin M, Allemand F, Melnyk P, Guichou JF, Cotelle P. Toward the Design of Ligands Selective for the C-Terminal Domain of TEADs J Med Chem 2022 doi:10.1021/acs.jmedchem.2c00075

Sturbaut M, Bailly F, Coevoet M, Sileo P, Pugniere M, Liberelle M, Magnez R, Thuru X, Chartier-Harlin MC, Melnyk P, Gelin M, Allemand F, Guichou JF, Cotelle P. Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors European Journal of Medicinal Chemistry 2021 doi:10.1016/j.ejmech.2021.113835

Patinote C, Deleuze-Masquéfa C, Kaddour KH, Vincent LA, Larive R, Zghaib Z, Guichou JF, Assaf MD, Cuq P, Bonnet PA. Imidazo[1,2-a]quinoxalines for melanoma treatment with original mechanism of action European Journal of Medicinal Chemistry 2021 doi:10.1016/j.ejmech.2020.113031

Gibault F, Sturbaut M, Coevoet M, Pugnière M, Burtscher A, Allemand F, Melnyk P, Hong W, Rubin BP, Pobbati AV, Guichou JF, Cotelle P, Bailly F. Design, Synthesis and Evaluation of a Series of 1,5?Diaryl?1,2,3?triazole?4?carbohydrazones as Inhibitors of the YAP?TAZ/TEAD Complex ChemMedChem 2021 doi:10.1002/cmdc.202100153

Schneider M, Pons JL, Labesse G. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding Journal of Medicinal Chemistry 2021 doi:10.1021/acs.jmedchem.1c01354

Panel M, Ahmed-Belkacem A, Ruiz I, Guichou JF, Pawlotsky JM, Ghaleh B, Morin D A phenyl pyrrolidine derivative reveals a dual inhibition mechanism of myocardial mitochondrial permeability transition pore, which is limited by its myocardial distribution. J Pharmacol Exp Ther. 2020 2020 doi:10.1124/jpet.120.000359

Ortiz-Cuaran S, Mezquita L, Swalduz A, Aldea M, Mazieres J, Leonce C, Jovelet C, Pradines A, Avrillon V, Chumbi Flores WR, Lacroix L, Loriot Y, Westeel V, Ngo-Camus M, Tissot C, Raynaud C, Gervais R, Brain E, Monnet I, Giroux Leprieur E, Caramella C, Mahier-Aït Oukhatar C, Hoog-Labouret N, de Kievit F, Howarth K, Morris C, Green E, Friboulet L, Chabaud S, Guichou JF, Perol M, Besse B, Blay JY, Saintigny P, Planchard D Circulating Tumor DNA Genomics Reveal Potential Mechanisms of Resistance to BRAF-Targeted Therapies in Patients with BRAF-Mutant Metastatic Non-Small Cell Lung Cancer. Clin Cancer Res 2020 doi:10.1158/1078-0432

Bayle M, Neasta J, Dall'Asta M, Gautheron G, Virsolvy A, Quignard JF, Youl E, Magous R, Guichou JF, Crozier A, Del Rio D, Cros G, Oiry C The Ellagitannin Metabolite Urolithin C is a Glucose-Dependent Regulator of Insulin Secretion through L-type Calcium Channel Activation Br J Pharmacol, 2019 in press

Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugue L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H First-in-class allosteric inhibitors of bacterial IMPDHs Eur J Med Chem 2019, 167: 124-132 PubMed Id 30769241

Bou Karroum N, Moarbess G, Guichou JF, Bonnet PA, Patinote C, Bouharoun-Tayoun H, Chamat S, Cuq P, Diab-Assaf M, Kassab I, Masquefa C Novel and selective TLR7 antagonists among the imidazo[1,2-a]pyrazines, imidazo[1,5-a]quinoxalines and pyrazolo[1,5-a]quinoxalines series J Med Chem 2019, 62 (15) 7015-7031 PubMed Id 31283223


Gibault F, Coevoet M, Sturbaut M, Farce A, Renault N, Allemand F, Guichou JF, Drucbert AS, Foulon C, Magnez R, Thuru X, Corvaisier M, Huet G, Chavatte P, Melnyk P, Bailly F, Cotelle P Toward the Discovery of a Novel Class of YAPa-TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAPaTEAD Proteina-Protein Interface Cancers (Basel) 2018,10:5 PubMed Id 29738494


Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation, Structure 2018, 26 (4): 545-554, PubMed Id 29503074

Loeuillet C, Touquet B, Oury B, Eddaikra N, Pons JL, Guichou JF, Labesse G, Sereno D Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity Int J Parasitol Drugs Drug Resist 2018, 8 (1): 59-66 PubMed Id 29414107

Vasiliauskaite-Brooks I, Healey RD, Rochaix P, Saint-Paul J, Sounier R, Grison C, Waltrich-Augusto T, Fortier M, Hoh F, Saied EM, Arenz C, Basu S, Leyrat C, Granier S Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy, Nat Commun 2018,9 (1): 5437 PubMed Id 30575723

Bonnel C, Legrand B, Simon M, Martinez J, Bantignies JL, Kang YK, Wenger E, Hoh F, Masurier N, Maillard LT C9/12-ribbon-like structure in hybrid peptides alternating α- and thiazole-based γ-amino acids Chemistry 2017,23 (69): 17584-17591 PubMed Id 28990697

M, Hoh F, De Colibus L, Bechara C, Saied EM, Arenz C, Leyrat C, Granier S Structural insights into adiponectin receptors suggest ceramidase activity Nature 2017, 544 (7648): 120-123 PubMed Id 28329765

Kaplan E, Guichou JF, Chaloin L, Kunzelmann S, Leban N, Serpersu EH, Lionne C Aminoglycoside binding and catalysis specificity of aminoglycoside 2a€³-phosphotransferase IVa: A thermodynamic, structural and kinetic study Biochim Biophys Acta 2016, 1860 (4): 802-813 PubMed Id 26802312

Moarbess G, Guichou JF, Paniagua-Gayraud S, Chouchou A, Marcadet O, Leroy F, Ruedas R, Cuq P, Deleuze-Masquefa C, Bonnet PA New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors, Eur J Med Chem 2016, 115: 268-274 PubMed Id 27017554

Paoletti J, Assairi L, Gelin M, Huteau V, Nahori MA, Dussurget O, Labesse G, Pochet S 8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode Eur J Med Chem 2016, 124: 1041-1056 PubMed Id 27783975


Zghaib Z, Guichou JF, Vappiani J, Bec N, Hadj-Kaddour K, Vincent LA, Paniagua-Gayraud S, Larroque C, Moarbess G, Cuq P, Kassab I, Deleuze-Masquefa C, Diab-Assaf M, Bonnet PA New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships Bioorg Med Chem 2016, 24(11):2433-40 PubMed Id 27094151

Bianchin A, Allemand F, Bell A, Chubb AJ, Guichou JF Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution Acta Crystallogr D Biol Crystallogr 2015,71 (6):1319-271319-27 PubMed Id 26057671

Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation Acta Crystallogr D Biol Crystallogr 2015, 71(9),1890-9 PubMed Id 26327379

Gelin M, Delfosse V, Allemand F, Hoh F, Sallaz-Damaz Y, Pirocchi M, Bourguet W, Ferrer JL, Labesse G, Guichou JF. Acta Crystallogr D Biol Crystallogr. 2015 71(Pt 8):1777-87. PubMed Id 26249358

Moser von Filseck J, Copic A, Delfosse V, Vanni S, Jackson CL, Bourguet W, Drin G INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate, Science 2015, 349 (6246):432-6 PubMed Id 26206936

Naveed H, Hameed US, Harrus D, Bourguet W, Arold ST, Gao X An integrated structure- and system-based framework to identify new targets of metabolites and known drugs Bioinformatics 2015,31(24):3922-9 PubMed Id 26286808


Aguirre C, Brink TT, Guichou JF, Cala O, Krimm I Comparing Binding Modes of Analogous Fragments Using NMR in Fragment-Based Drug Design: Application to PRDX5 PLoS ONE 2014, 9(7): e102300 PubMed Id 25025339

Aguirre C, Ten Brink T, Cala O, Guichou JF, Krimm I Protein-ligand structure guided by backbone and side-chain proton chemical shift perturbations J Biomol NMR 2014, 60(2-3):147-56 PubMed Id 25256941

Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: Synthesis, structural studies and cytotoxic activities Eur J Med Chem, 2014, 85C: 418-437 PubMed Id 25108359 (pôle RMN aussi)

Ahmed-Belkacem A, Guichou JF, Brillet R, Ahnou N, Hernandez E, Pallier C, Pawlotsky JM. Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention. Nucleic Acids Res. 2014 Aug;42(14):9399-409. PubMed Id 25053847

Godreuil S, Leban N, Padilla A, Hamel R, Luplertlop N, Chauffour A, Vittecoq M, Hoh F, Thomas F, Sougakoff W, Lionne C, Yssel H, Misse D Aedesin: Structure and Antimicrobial Activity against Multidrug Resistant Bacterial Strains PLoS ONE 2014, 9 (8): e105441 PubMed Id 25108359 25162372

 

 

Pôle Bioinformatique

Colman DR, Labesse G, Swapna GVT, Stefanakis J, Montelione GT, Boyd ES, Royer CA Structural evolution of the ancient enzyme, dissimilatory sulfite reductase Proteins 2022 doi:10.1002/prot.26315

Jublot D, Cavaillès P, Kamche S, Francisco D, Fontinha D, Prudêncio M, Guichou JF, Labesse G, Sereno D, Loeuillet C. A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti- Toxoplasma and Anti- Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice Int J Mol Sci 2022 doi:10.3390/ijms23063254

Mairot K, Smirnov V, Bocquet B, Labesse G, Arndt C, Defoort-Dhellemmes S, Zanlonghi X, Hamroun D, Denis D, Picot MC, David T, Grunewald O, Pégart M, Huguet H, Roux AF, Kalatzis V, Dhaenens CM, Meunier I. CRB1-Related Retinal Dystrophies in a Cohort of 50 Patients: A Reappraisal in the Light of Specific Müller Cell and Photoreceptor CRB1 Isoforms Int J Mol Sci 2022 doi:10.3390/ijms222312642

Lazar N, Mesarich CH, Petit-Houdenot Y, Talbi N, de la Sierra-Gallay IL, Zelie E, Blondeau K, Gracy J, Ollivier B, Blaise F, Rouxel T, Balesdent MH, Idnurm A, van Tilbeurgh H, Fudal I A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins Plos pathogens 2022 doi:10.1371/journal.ppat.1010664.

Xi Y, Chalvon V, Padilla A, Cesari S, Kroj T. The activity of the RGA5 sensor NLR from rice requires binding of its integrated HMA domain to effectors but not HMA domain self-interaction Mol Plant Pathogens 2022 doi:10.1111/mpp.13236.

Labbé JC, Vigneron S, Méchali F, Robert P, Roque S, Genoud C, Goguet-Rubio P, Barthe P, Labesse G, Cohen-Gonsaud M, Castro A, Lorca T The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop Nature Communications 2021 doi:10.1038/s41467-021-23657-0

Mairot K, Smirnov V, Bocquet B, Labesse G, Arndt C, Defoort-Dhellemmes S, Zanlonghi X, Hamroun D, Denis D, Picot MC, David T, Grunewald O, Pégart M, Huguet H, Roux AF, Kalatzis V, Dhaenens CM, Meunier I. CRB1-Related Retinal Dystrophies in a Cohort of 50 Patients: A Reappraisal in the Light of Specific Müller Cell and Photoreceptor CRB1 Isoforms International Journal of Molecular Sciences 2021 doi:10.3390/ijms222312642

Biquet-Bisquert A, Labesse G, Pedaci F, Nord AL. The Dynamic Ion Motive Force Powering the Bacterial Flagellar Motor Frontiers in Microbiology 2021 doi:10.3389/fmicb.2021.659464

Schneider M, Pons JL, Labesse G. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding Journal of Medicinal Chemistry 2021 doi:10.1021/acs.jmedchem.1c01354

Fleury C, Gracy J, Gautier MF, Pons JL, Dufayard JF, Labesse G, Ruiz M, de Lamotte F Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its sequence-structure-function analysis PeerJ 2019,7:e7504 PubMed Id 31428542

Hajj M, De Vita T, Vol C, Renassia C, Bologna JC, Brabet I, Cazade M, Pastore M, Blahos J, Labesse G, Pin JP, Prezeau L Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein-Coupled Receptor Mol Pharmacol 2019, 96 (2): 233-246 PubMed Id 31189666


Lopez-Sanchez U, Nicolas G, Richard AC, Maltete D, Charif M, Ayrignac X, Goizet C, Touhami J, Labesse G, Battini JL, Sitbon M Characterization of XPR1/SLC53A1 variants located outside of the SPX domain in patients with primary familial brain calcification Sci Rep 2019, 9(1): 6776 PubMed Id 31043717

Renault P, Louet M, Marie J, Labesse G, Floquet N Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2A Receptor by a Mini-G Protein Sci Rep 2019, 9 (1): 5495 PubMed Id 30940903

Bonneau M, Atyame C, Beji M, Justy F, Cohen-Gonsaud M, Sicard M, Weill M Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia Nat Commun, 2018,9,1,319 PubMed Id 29358578

Meunier I, Bocquet B, Labesse G, Zeitz C, Defoort-Dhellemmes S, Lacroux A, Mauget-Faysse M, Drumare I, Gamez AS, Mathieu C, Marquette V, Sagot L, Dhaenens CM, Arndt C, Carroll P, Remy-Jardin M, Cohen SY, Sahel JA, Puech B, Audo I, Mrejen S, Hamel CP A new autosomal dominant eye and lung syndrome linked to mutations in TIMP3 gene Sci Rep 2016,6 ,32544 PubMed Id 27601084

Meunier I, Lenaers G, Bocquet B, Baudoin C, Piro-Megy C, Cubizolle A, Quiles M, Jean-Charles A, Cohen SY, Merle H, Gaudric A, Labesse G, Manes G, Pequignot M, Cazevieille C, Dhaenens CM, Fichard A, Ronkina N, Arthur SJ, Gaestel M, Hamel CP A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium Hum Mol Genet 2016,25(5):916-26 PubMed Id 26744326

Sagnol S, Yang Y, Bessin Y, Allemand F, Hapkova I, Notarnicola C, Guichou JF, Faure S, Labesse G, de Santa Barbara P Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity Nucleic Acids Res 2014, 42(15):10173-84: PubMed Id 25064856 (également pole RMN)

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions Antimicrob Agents Chemother 2014, 58 (5):2798-806 PubMed Id 24590482

Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV Oleoyl-Coenzyme A Regulates Interaction of Transcriptional Regulator RaaS (Rv1219c) with DNA in Mycobacteria J Biol Chem 2014, 289(36):25241-9 PubMed Id 25012658



 

 

Pôle Cheminfo

Loeuillet C, Touquet B, Guichou JF, Labesse G, Sereno D A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor, Int J Mol Sci 2019, 20 :12 PubMed Id 31216674



 

 

Pôle Microscopies Optiques

Barho F, Fiche JB, Bardou M, Messina O, Martiniere A, Houbron C, Nollmann M. Qudi-HiM: an open-source acquisition software package for highly multiplexed sequential and combinatorial optical imaging Open Research Europe 2022 doi:10.12688/openreseurope.14641.2)

Rombouts, R, Fiche, JB, Mignot, T, Nollmann,M bacto_tracker: a method for single-cell tracking of M. xanthus in dense and multispecies colonies Open Research Europe 2022 doi:10.12688/openreseurope.15255.1

Eid J, Socol M, Naillon A, Feuillard J, Ciandrini L, Margeat E, Charlot B, Mougel M. Viro-fluidics: Real-time analysis of virus production kinetics at the single-cell level Biophys Rep 2022 doi:10.1016/j.bpr.2022.100068

Vial A , Taveneau C , Costa L , Chauvin B , Nasrallah H , Godefroy C , Dosset P , Isambert H , Ngo KX , Mangenot S , Levy D , Bertin A , Milhiet PE Correlative AFM and fluorescence imaging demonstrate nanoscale membrane remodeling and ring-like and tubular structure formation by septins Nanoscale 2021 doi:10.1039/D1NR01978C

Panigrahi S, Murat D, Le Gall A, Martineau E, Goldlust K, Fiche JB, Rombouts S, Nöllmann M, Espinosa L, Mignot T. Misic, a general deep learning-based method for the high-throughput cell segmentation of complex bacterial communities eLife 2021 doi:10.7554/eLife.65151

Bourges AC, Torres Montaguth OE, Tadesse W, Labesse G, Aertsen A, Royer CA, Declerck N. An oligomeric switch controls the Mrr-induced SOS response in E. coli DNA Repair 2021 doi:10.1016/j.dnarep.2020.103009

Cardozo Gizzi AM, Espinola SM, Gurgo J, Houbron C, Fiche JB, Cattoni DI, Nollmann M. Direct and simultaneous observation of transcription and chromosome architecture in single cells with Hi-M Nature Protocols 2020

Bourges AC, Torres Montaguth OE, Tadesse W, Labesse G, Aertsen A, Royer CA, Declerck N. An oligomeric switch controls the Mrr-induced SOS response in E. coli. DNA Repair 2020 doi:10.1016/j.dnarep.2020.103009

Martiniere A, Fiche JB, Smokvarska M, Mari S, Alcon C, Dumont X, Hematy K, Jaillais Y, Nollmann M, Maurel C Osmotic stress activates two reactive oxygen species pathways with distinct effects on protein nanodomains and diffusion Plant Physiol 2019, 179 ( 4): 1581-1593 PubMed Id 30718348


Nadiras C, Delaleau M, Schwartz A, Margeat E, Boudvillain M A fluorogenic assay to monitor Rho-dependent termination of transcription Biochemistry 2019, 58(7):865-874 PubMed Id 30624903


Platre MP, Bayle V, Armengot L, Bareille J, Marques-Bueno MDM, Creff A, Maneta-Peyret L, Fiche JB, Nollmann M, Miege C, Moreau P, Martiniere A, Jaillais Y Developmental control of plant Rho GTPase nano-organization by the lipid phosphatidylserine Science 2019,364(6435):57-62 PubMed Id 30948546

Quast RB, Fatemi F, Kranendonk M, Margeat E, Truan G Accurate Determination of Human CPR Conformational Equilibrium by smFRET using Dual Orthogonal Non-Canonical Amino Acid Labeling Chembiochem, 2019, 20(5): 659-666 PubMed Id 30427570

Marti-Renom MA, Almouzni G, Bickmore WA, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME Challenges and guidelines toward 4D nucleome data and model standards Nat Genet, 2018, 50 (1):1352-1358 PubMed Id 30262815

M¸ller TC, Hottin J, Clerte C, Zwier JM, Durroux T, Rondard P, Prezeau L, Royer CA, Pin JP, Margeat E, Kniazeff J Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics, Sci Rep 2018, 8(1):10414 PubMed Id 29991736


Tora AS, Rovira X, Cao AM, Cabaye A, Olofsson L, Malhaire F, Scholler P, Baik H, Van Eeckhaut A, Smolders I, Rondard P, Margeat E, Acher F, Pin JP, Goudet C Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3 Neuropharmacology 2018, 140:275-286 PubMed Id 30102917

Vishwakarma RK, Cao AM, Morichaud Z, Perumal AS, Margeat E, Brodolin K Single-molecule analysis reveals the mechanism of transcription activation in Sci Adv 2018, 4:5 PubMed Id 29806016


Walter JC, Dorignac J, Lorman V, Rech J, Bouet JY, Nollmann M, Palmeri J, Parmeggiani A, Geniet F Surfing on Protein Waves: Proteophoresis as a Mechanism for Bacterial Genome Partitioning Phys Rev Lett 2017, 119:2 PubMed Id 28753349


de Torres J, Mivelle M, Moparthi SB, Rigneault H, van Hulst NF, Garcia-Parajo MF, Margeat E, Wenger J Plasmonic Nanoantennas Enable Forbidden Forster Dipole-Dipole Energy Transfer and Enhance the FRET Efficiency Nano Lett 2016, 16(10):6222-6230. PubMed Id 27623052

Faure LM, Fiche JB, Espinosa L, Ducret A, Anantharaman V, Luciano J, Lhospice S, Islam ST, Treguier J, Sotes M, Kuru E, Van Nieuwenhze MS, Brun YV, Theodoly O, L A, Nollmann M, Mignot T The mechanism of force transmission at bacterial focal adhesion complexes Nature 2016, 539(7630):530-535 PubMed Id 27749817

Ferrer M, Clerte C, Chamontin C, Basyuk E, Laine S, Hottin J, Bertrand E, Margeat E, Mougel M Imaging HIV-1 RNA dimerization in cells by multicolor super-resolution and fluctuation microscopies Nucleic Acids Res 2016, 44(16):7922-34. PubMed Id 27280976


Konate K, Lindberg M, Vaissiere A, Jourdan C, Aldrian G, Margeat E, Deshayes S, Boisguerin P Optimisation of vectorisation property: a comparative study for a secondary amphipathic peptide Int J Pharm 2016, 509(1-2):71-84 PubMed Id 27224007

Sanchez A, Cattoni DI, Walter JC, Rech J, Parmeggiani A, Nollmann M, Bouet JY Stochastic Self-Assembly of ParB Proteins Builds the Bacterial DNA Segregation Apparatus Cell Syst 2015, 1(2):163-73 PubMed Id 27135801


Liang J, Lacroix L, Gamot A, Cuddapah S, Queille S, Lhoumaud P, Lepetit P, Martin PG, Vogelmann J, Court F, Hennion M, Micas G, Urbach S, Bouchez O, Nollmann M, Zhao K, Emberly E, Cuvier O Chromatin Immunoprecipitation Indirect Peaks Highlight Long-Range Interactions of Insulator Proteins and Pol II Pausing Mol Cell 2014, 53(4):672-81 PubMed Id 24486021


Moutin E, Compan V, Raynaud F, Clerte C, Bouquier N, Labesse G, Ferguson ML, Fagni L, Royer CA, Perroy J Stoichiometry of scaffold complexes in living neurons - DLC2 as a dimerization engine for GKAP J Cell Sci 2014, 127(Pt 16):3451-62 PubMed Id 24938595 (également Pole Bioinfo).

Olofsson L, Felekyan S, Doumazane E, Scholler P, Fabre L, Zwier JM, Rondard P, Seidel CA, Pin JP, Margeat E Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy Nat Commun 2014 5: 5206 PubMed Id 25323157

Soares E, Schwartz A, Nollmann M, Margeat E, Boudvillain M The RNA-mediated, asymmetric ring regulatory mechanism of the transcription termination Rho helicase decrypted by time-resolved Nucleotide Analog Interference Probing (trNAIP) Nucleic Acids Res 2014, 42(14):9270-84 PubMed Id 25016524



 

 

Pôle AFM

Vial A , Taveneau C , Costa L , Chauvin B , Nasrallah H , Godefroy C , Dosset P , Isambert H , Ngo KX , Mangenot S , Levy D , Bertin A , Milhiet PE Correlative AFM and fluorescence imaging demonstrate nanoscale membrane remodeling and ring-like and tubular structure formation by septins Nanoscale 2021 doi:10.1039/D1NR01978C

Ordas L, Costa L, Lozano A, Chevillard C, Calovoulos A, Kantar D, Fernandez L, Chauvin L, Dosset P, Doucet C, Heron-Milhavet L, Odintsova E, Berditchevski F, Milhiet PE, Bénistant C Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1 Cells 2021 doi:10.3390/cells10061545

Kantar D, Mur EB, Mancini M, Slaninova V, Salah YB, Costa L, Forest E, Lassus P, Géminard C, Boissière-Michot F, Orsetti B, Theillet C, Colinge J, Benistant C, Maraver A, Heron-Milhavet L, Djiane A. MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis Scientific Reports 2021 doi:10.1038/s41598-021-85056-1

Ngo G, Félix G, Dorandeu C, Devoisselle JM, Costa L, Milhiet PE, Guari Y, Larionova J, Chopineau J. A Novel Approach to the Facile Growth and Organization of Photothermal Prussian Blue Nanocrystals on Different Surfaces Nanomaterials 2021 doi:10.3390/nano11071749

Juarez JF, Judge, PJ, Adam, A, Axford, D, Vinals, J, Birch, J, Kwan, TOC, Kuan Hoi, K, Yen, HY, Vial? A, Milhiet, PE, Robinson CV, Shapiro, I, Moraes, I, Watts A. Disordering of internal water networks underpins receptor sensitisation: high-resolution structures of the Archaerhodopsin-3 H+ transporter Nature Communications 2020 doi:10.1038/s41467-020-20596-0

Serulla, M., Ichim, G., Stojceski, F., Grasso, G., Afonin, S., Schober, T., Roth, R., Godefroy, C., Milhiet, P.E., Das, K., Garcia Saez, A., Danani, A., and Widmann, C TAT-RasGAP317-326 kills cells by targeting inner leaflet-enriched phospholipids. PNAS 2020 doi:10.1073/pnas.2014108117

Saavedra O., Fernandes T., Milhiet P.-E., Costa L. Compression, Rupture, and Puncture of Model Membranes at the Molecular Scale Langmuir 2020 doi:10.1021/acs.langmuir.0c00247

Fernandes T., Saavedra O., Margeat E., Milhiet P.-E., Costa L. Synchronous, Crosstalk-free Correlative AFM and Confocal Microscopies/Spectroscopies Scientific Reports 2020 doi:10.1038/s41598-020-62529-3

Bada Juarez JF, Judge PJ, Adam S, Axford D, Vinals J, Birch J, Kwan TOC, Hoi KK, Yen HY, Vial A, Milhiet PE, Robinson CV, Schapiro I, Moraes I, Watts A Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization Nature Communications 2021 doi:10.1038/s41467-020-20596-0

Ngo G, Felix G, Long J, Costa L, Saavedra O V, Milhiet P E, Devoisselle J M, Guari Y, Larionova J, Chopineau J. A simple approach for controlled deposition of Prussian Q1 blue analogue nanoparticles on a functionalised plasmonic gold surface. New Journal of Chemistry, in press, 2019.

Theodoratou A, Costa L, Bonnet L, Blanc C, Lapinte V, Etienne P, Milhiet P E, Robin J J, Oberdisse, Chopineau J, Pouessel A A, Physico-chemical properties and surface characterization of renewable hybrid nanofilms interacting with model proteins. European Polymer Journal, 111, 2018.

Gumi-Audenis B, Costa L, Redondo-Morata L, Milhiet P E, Sanz F, Felici R, Giannotti M I, Carla F. In-plane molecular organization of hydrated single lipid bilayers: Dppc:cholesterol. Nanoscale, 10:87–92, 2018

Gumi-Audenis B, Costa L, Ferrer-Tasies L, Ratera I, Ventosa N, Sanz F, Giannotti M I, Pulling lipid tubes from supported bilayers unveils the underlying substrate contribution to the membrane mechanics. Nanoscale, 10(30):14763-14770, 2018.

Carrillo-Vazquez JP, Correa-Basurto J, Garcia-Machorro J, Campos-Chamontin C, Rassam P, Ferrer M, Racine PJ, Neyret A, Laine S, Milhiet PE, Mougel M HIV-1 nucleocapsid and ESCRT-component Tsg101 interplay prevents HIV from turning into a DNA-containing virus Nucleic Acids Res 2015, 43 (1): 336-47 PubMed Id 25488808

Greiner VJ, Manin C, Larquet E, Ikhelef N, Greco F, Naville S, Milhiet PE, Ronzon F, Klymchenko A, Mely Y Characterization of the structural modifications accompanying the loss of HBsAg particle immunogenicity Vaccine 2014 32 (9): 1049-54 PubMed Id 24440114

Guyomarc'h F, Zou S, Chen M, Milhiet PE, Godefroy C, Vie V, Lopez C Milk sphingomyelin domains in biomimetic membranes and the role of cholesterol: morphology and nanomechanical properties investigated using AFM and force spectroscopy Langmuir 2014 , 30(22):6516-24 PubMed Id 24835749



 

 

Caractérisations biophysiques

Arsic N, Slatter T, Gadea G, Villain E, Fournet A, Kazantseva M, Allemand F, Sibille N, Seveno M, de Rossi S, Mehta S, Urbach S, Bourdon JC, Bernado P, Kajava AV, Braithwaite A, Roux P. ?133p53? isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells Nature Communications 2021 doi:10.1038/s41467-021-25550-2

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