Centre de Biologie Structurale

News

Seminars

02 Jun

Biophysics Seminar: Marcelo Nollmann 02 Jun 2025 11:00 AM to 12:00 PM
03 Jun

Introductory course on fluid mechanics & microfluidics -VIII-Manouk Abkarian 03 Jun 2025 12:30 PM to 01:45 PM
03 Jun

Conseil de Direction 03 Jun 2025 02:00 PM to 04:00 PM

02 Jun - 03 Jun
04 Jun - 06 Jun
10 Jun - 16 Jun
19 Jun - 26 Jun
27 Jun - 01 Jul
01 Jul - 04 Jul
04 Jul - 05 Aug

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Latest publications

Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
Lleres D, Gizzi AC, Nollmann M, Curr Opin Cell Biol, 2025
Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET
Bonhomme L, Bilgen E, Clerte C, Pin JP, Rondard P, Margeat E, Lamb DC, Quast RB, J Am Chem Soc, 2025
Editorial overview: Emerging perspectives in genome architecture and gene regulation
Nollmann M, Hansen AS, Curr Opin Genet Dev, 2025
Molecular Assemblies of Amphiphilic Oligothiophenes at the Air-Water Interface
Idriss H, Albert S, Bae C, Poyac L, Gerbier P, Bonhomme O, Lai-Kee-Him J, Ancelin A, Richeter S, Sen I, Leo K, Biance AL, Clement S, Langmuir, 2025
Structural and Functional Characterization of the 28kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti
Mouhand A, Pissarra J, Barthe P, Roumestand C, Delbecq S, Proteins, 2025
Single-stranded DNA drives sigma subunit loading onto mycobacterial RNA polymerase to unlock initiation-competent conformations
Vishwakarma RK, Marechal N, Morichaud Z, Blaise M, Margeat E, Brodolin K, Nucleic Acids Res, 2025
Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations
Boccalini M, Berezovska Y, Bussi G, Paloni M, Barducci A, Proc Natl Acad Sci U S A, 2025
Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli
Droghetti R, Fuchs P, Iuliani I, Firmano V, Tallarico G, Calabrese L, Grilli J, Sclavi B, Ciandrini L, Cosentino Lagomarsino M, Nat Commun, 2025
Structure of the turnip yellows virus particles
Lai-Kee-Him J, Trapani S, Boissinot S, Reinbold C, Fallet C, Ancelin A, Lecorre F, Hoh F, Ziegler-Graff V, Brault V, Bron P, Virology, 2025
K_DSAXS: A Tool for Analyzing Binding Equilibria With SAXS Data Using Explicit Models
Gomes T, Ruiz L, Martin-Malpartida P, Bernado P, Baptista AM, Macias MJ, Cordeiro TN, J Mol Biol, 2025
Structure-guided insights into the biology of fungal effectors
Le Naour-Vernet M, Lahfa M, Maidment JHR, Padilla A, Roumestand C, deGuillen K, Kroj T, Cesari S, New Phytol, 2025
Understanding the Relationship between Pressure and Temperature Unfolding of Proteins
Roumestand C, Dudas E, Puglisi R, Calio A, Barthe P, Temussi PA, Pastore A, JACS Au, 2025
GEF14 acts as a specific activator of the plant osmotic signaling pathway by controlling ROP6 nanodomain formation
Gorgues L, Smokvarska M, Mercier C, Igisch CP, Crabos A, Dongois A, Bayle V, Fiche JB, Nacry P, Nollmann M, Jaillais Y, Martiniere A, EMBO Rep, 2025
A mechanism for ligand-dependent activation of AHR
Guesdon A, Bourguet W, Trends Pharmacol Sci, 2025
AFflecto: A web server to generate conformational ensembles of flexible proteins from AlphaFold models
Pajkos M, Clerc I, Zanon C, Bernado P, Cortes J, J Mol Biol, 2025
Binding-Site Switch for Protein Kinase CK2 Inhibitors
Grenier D, Gelin M, Yang Y, Mularoni A, Guichou JF, Delcros JG, Krimm I, ChemMedChem, 2025
A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target
Carivenc C, Laconde G, Blanc P, Amblard M, Bourguet W, Delfosse V, Acta Crystallogr F Struct Biol Commun, 2025
An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice
Wang X, Zhang G, Bian Z, Chow V, Grimaldi M, Carivenc C, Sirounian S, Li H, Sladekova L, Mott S, Luperi Y, Gong Y, Costello C, Li L, Jachimowicz M, Guo M, Hu S, Wilson D, Balaguer P, Bourguet W, Mani S, Bonati L, Peng H, March J, Wang H, Wang S, Krause HM, Liu J, Nat Commun, 2025
APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus
Kaplan E, Chaloin L, Guichou JF, Berrou K, Rahimova R, Labesse G, Lionne C, ChemMedChem, 2025
Cryo-EM structure and regulation of human NAD kinase
Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G, Sci Adv, 2025
Binding-site switch of Protein Kinase CK2 inhibitors
Krimm I, Grenier D, Gelin M, Yang Cbs Cnrs Fr Y, Mularoni A, Guichou JF, Delcros JG, ChemMedChem, 2025
Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides
Pradeau-Phelut L, Alves S, Le Tareau L, Larralde C, Bernard E, Schirmer C, Lai-Kee-Him J, Lepvrier E, Bron P, Delamarche C, Garnier C, Anal Chem, 2025
Microbes Saving Lives and Reducing Suffering
Timmis K, Karahan ZC, Ramos JL, Koren O, Perez-Cobas AE, Steward K, de Lorenzo V, Caselli E, Douglas M, Schwab C, Rivero V, Giraldo R, Garmendia J, Turner RJ, Perlmutter J, Borrero de Acuna JM, Nikel PI, Bonnet J, Sessitsch A, Timmis JK, Pruzzo C, Prieto MA, Isazadeh S, Huang WE, Clarke G, Ercolini D, Haggblom M, Microb Biotechnol, 2025
Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues
Elena-Real CA, Urbanek A, Sagar A, Mohanty P, Levy G, Morato A, Fournet A, Allemand F, Sibille N, Mittal J, Sinnaeve D, Bernado P, Chemistry, 2024
Measuring Bacterial Flagellar Motor Dynamics via a Bead Assay
Hoffmann WH, Biquet-Bisquert A, Pedaci F, Nord AL, Methods Mol Biol, 2024
Determining the Relative Affinity of ORPs for Lipid Ligands Using Fluorescence and Thermal Shift Assays
Delfosse V, Drin G, Methods Mol Biol, 2024
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants
le Maire A, Bourguet W, Annu Rev Pharmacol Toxicol, 2024
Self-Assembled Peptide-Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells
Moro S, Omrani M, Erbek S, Jourdan M, Vandekerckhove CI, Nogier C, Vanwonterghem L, Molina MC, Bernado P, Thureau A, Coll JL, Renaudet O, Le Guevel X, Faure V, Small Sci, 2024
Structural Insights Into Thyroid Hormone Receptors
Tambones I, le Maire A, Endocrinology, 2024
Structural basis of orientated asymmetry in a mGlu heterodimer
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J, Nat Commun, 2024

View all publications

VP ITC Microcalorimetry

*Equipement*	VP ITC Microcalorimetry
*Measure*	Determination of affinity constants in protein/protein or protein/ligand or protein/DNA interactions. Determination of the stoichiometry of the biochemical interaction. Determination of thermodynamic constants such the enthalpy and the entropy.
Sample volume 2 ml at around 10-20 uM for the protein, 500 ul at 100-200 uM for the ligand. Duration 3 hours.
	Isothermal titration calorimeter VP-ITC MicroCal (Malvern InstrumentsTM)
*Specifications*	https://www.malvernpanalytical.com/fr/support/product-support/microcal-range/microcal-itc-range/microcal-vp-itc
*Room*	Z2-16@CBS29

SEC-MALS

*Equipement*	SEC- MALS
*Measure*	Determination of molecular weight of proteins, protein/protein complexes, proteins/nucleic acids, nanodisks…Determination of protein oligomerization state and stoichiometry of complexes.
Sample volume 20 ul at 2 mg/ml, duration 1 hours. Different size exclusion columns available.
	SEC –MALS : HPLC (AgilentTM Infinity II), Detector LS (miniDAWN TREOS – WayttTM), refractometry (Optilab T-rEX – WayttTM).
*Specifications*	https://www.wyatt.com/products/instruments/minidawn-multi-angle-light-scattering-detector-sec-mals.html https://www.wyatt.com/products/instruments/optilab-refractive-index-detector.html
*Room*	Z1-5@CBS29

Dynamic Light Scattering (DLS)

*Equipement*	Dynamic Light Scattering (DLS)
*Measure*	Molecule hydrodynamic radius measurement.
Measurement in microcuvettes. Reaction volume 40 ul with a final protein concentration around 100 uM. Duration 15 min.
	DLS Zetasizer Nano-S (Malvern Instrument TM)
*Specifications*	https://www.malvernpanalytical.com/fr/products/product-range/zetasizer-range/zetasizer-nano-range/zetasizer-nano-s
*Room*	Z2-16@CBS29

Nano DSF

*Equipement*	Nano DSF
*Measure*	Tm measurement
Simultaneous measurements of 6 different proteins or conditions. Sample volume 10 ul. Duration 3 min.
	Nanotemper™ Tycho NT.6
*Specifications*	https://nanotempertech.com/tycho/
*Room*	Z2-16@CBS29

Circular Dichroism

*Equipement*	Circular Dichroism
*Measure*	Respective proportion estimation of the different secondary structure elements present in a protein.
Precision cells; light path 0,1 - 0,2 - 0,5 - 1 - 2 - 5 - 10 mm. Final protein concentration around 50-100 uM. Duration 10 min.
	CD Chirascan (Applied Biophysics TM)
*Specifications*	https://www.photophysics.com/systems/chirascan-systems/chirascan/system-information/
*Room*	Z2-16@CBS29

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CBS Teams

Structure, Dynamics and Function of biomolecules by NMR

Christian Roumestand and Nathalie Declerck
Structure and function of highly flexible proteins

Pau Bernadó and Nathalie Sibille
Multi-scale structural biology

Patrick Bron
ABCIS

Gilles Labesse
Nuclear Receptors as Integrators of Endogenous and Environmental Signals

William Bourguet and Albane Le Maire
Multiscale Biomolecular Modeling

Alessandro Barducci
Mechanisms of DNA Segregation and Remodelling

Marcelo Nollmann
Physics and mechanics of biological systems

Manouk Abkarian and Francesco Pedaci
Integrative Biophysics of Membranes

Pierre-Emmanuel Milhiet and Emmanuel Margeat
Synthetic Biology

Jérôme Bonnet and Martin Cohen-Gonsaud
Multiscale Biomolecular Modeling

Alessandro Barducci
Chromosome structure and homologous recombination in meiosis

Thomas Robert
Functional and synthetic genomics

Guillaume Cambray
Structure and function of the aryl hydrocarbon receptor

Jakub Gruszczyk

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