Centre de Biologie Structurale

 
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  • 23 May
    CTS: TEAM 2 23 May 2024 11:00 AM to 12:00 PM

    CBS Internal Teams Seminars

  • 27 May
    Biophysics Meeting: Gerrit Wilkens 27 May 2024 11:00 AM to 12:00 PM

  • 27 May
    Comité de direction CBS 27 May 2024 02:00 PM to 04:00 PM

  • 23 May - 27 May
  • 31 May - 06 Jun
  • 10 Jun - 14 Jun
  • 17 Jun - 24 Jun
  • 27 Jun - 01 Jul
  • 02 Jul - 08 Jul
  • 12 Jul - 25 Jul

Latest publications

Memberships

frisbi

The French Infrastructure for Integrated Structural Biology (FRISBI) provides an infrastructure for integrative structural biology approaches, from the molecular to the cellular level, integrating multi-resolution data from X-ray crystallography, small angle X-ray scattering, NMR, Cryo-EM and functional data including development for protein expression and crystallization. FRISBI is open to structural and molecular and cell biologists from both academia and industry from France and Europe.

 


 France-BioImaging H80px

France‐BioImaging is a large‐scale national research infrastructure. France-Bioimaging will deploy a distributed biological imaging infrastructure in a coordinated and harmonized manner. At the frontier between molecular and cell biology, biophysics and engineering, mathematics and bioinformatics, France-BioImaging gathers, several outstanding biological Imaging Centerssupported by state of the art R&D teams with the aim to cover recent advances in microscopy, spectroscopy, probe engineering and signal processing. Thereby France-BioImaging will provide quantitative measurements, computational analysis and an integrative understanding of a wide range of cellular and tissular activities.

France-BioImaging is a highly pluridisciplinary project with participants in Biology, Physics, Chemistry, Computer science and engineering. The strength of the France-BioImaging consortium is to put efforts together to overcome technological barriers persisting at different levels of Cellular Imaging. Different solutions for each challenge are proposed among different nodes, justifying a second level of France BioImaging organization as shared technological and methodological Work Packages.

More information on the France BioImaging website

 


ChemBioFrance H70px

 

By ministerial decision of May 8, 2018, ChemBioFrance is created and registered on the national roadmap of research infrastructures. ChemBioFrance gathers four different ressources and networks: the national chemical library, a network of screening platforms, a distributed chemoinformatics platform, a network of ADME platforms.

Its management is entrusted to the Institute of Chemistry (INC) of the Centre National de la Recherche Scientifique (CNRS), which delegates management to a Research Federation: ChemBioFrance.

It offers « smart »chemical libraries with high potential for bioactivity, partnership with chemists for medicinal chemistry, drug screening services, tools for data analysis and data mining in chemical collections, ADME and toxicology services for the characterization and development of new biologically active molecules.

Its activities include :

  • Conception and analyzing of chemical library for screening.
  • Analyzing of screening gross data.
  • Virtual screening (similarity 2D and 3D, pharmaceutical library, docking).
  • Biological profiling of molecules (target prediction).
  • Calcul/ Prediction of physicochemical properties (e.g: solubility, logP)

More information on the ChemBioFrance website

 


Logo BioCampus

BioCampus Montpellier is the service unit of the RABELAIS BioHealth Cluster (Pôle Biologie-Santé). This unit is jointly funded and managed by CNRS (UMS 3426), INSERM (US 09), and Montpellier University. BioCampus Montpellier manages the main technological platforms dedicated to Life Science research in the Mediterranean part of the French Occitanie region. Beside the BioHealth domain, BioCampus Montpellier is open to the entire scientific community, particularly to biotechnology companies, pharmaceutical research, agricultural sciences and ecology, and environmental sciences.

 


ibisa

 

The GIS (Scientific Interest Group) IBiSA (Infrastrutures en Biologie Sante et Agronomie) was created in May 2007. The current members of the GIS are INSERM, CNRS, INRA, CEA, INRIA, 'INCa (National Cancer Institute), the CPU (Conference of University Presidents), and the two directorates of the Ministry of Higher Education and Research, the DGRI and the DGES. The Presidency of the GIS is ensured by Yves Lévy.
It coordinates the national labeling policy and support for Platforms and Infrastructures in Life Sciences. With this in mind, GIS is taking up the policy of labeling and supporting technical personnel for the Platforms previously carried out by the Inter-Organism Meeting (RIO), and is piloting calls for projects intended to equip these platforms or to enable them to promote implementation of new technologies.
It promotes the establishment of structures for consultation and management of platforms at the regional level, which are intended to become privileged interlocutors of GIS IBiSA in the field.
It promotes animation activities (schools, thematic workshops, etc.) around the activity of the platforms.
For each of these missions, GIS launches calls for tenders.

 

Frisbi

The French Infrastructure for Integrated Structural Biology (FRISBI) provides an infrastructure for integrative structural biology approaches, from the molecular to the cellular level, integrating multi-resolution data from X-ray crystallography, small angle X-ray scattering, NMR, Cryo-EM and functional data including development for protein expression and crystallization. FRISBI is open to structural and molecular and cell biologists from both academia and industry from France and Europe.

Informations

FBI

FRANCE BIO-IMAGING

France‐BioImaging is a large‐scale national research infrastructure. France-Bioimaging will deploy a distributed biological imaging infrastructure in a coordinated and harmonized manner. At the frontier between molecular and cell biology, biophysics and engineering, mathematics and bioinformatics, France-BioImaging gathers, several outstanding biological Imaging Centerssupported by state of the art R&D teams with the aim to cover recent advances in microscopy, spectroscopy, probe engineering and signal processing. Thereby France-BioImaging will provide quantitative measurements, computational analysis and an integrative understanding of a wide range of cellular and tissular activities.

France-BioImaging is a highly pluridisciplinary project with participants in Biology, Physics, Chemistry, Computer science and engineering. The strength of the France-BioImaging consortium is to put efforts together to overcome technological barriers persisting at different levels of Cellular Imaging. Different solutions for each challenge are proposed among different nodes, justifying a second level of France BioImaging organization as shared technological and methodological Work Packages.

 

More information on the France BioImaging website

Le récepteur de la morphine dans tous ses états

Une collaboration étroite entre l'équipe de Sébastien Granier (IGF) de Montpellier, Hélène Déméné (CBS, de l'équipe « RMN, Structure, Dynamique et Fonction des Biomolécules par RMN ») et l'équipe du Pr. Brian Kobilka de l'Université de Stanford, lauréat du prix Nobel de chimie en 2012, a permis de décrypter les mécanismes moléculaires de l'activation du récepteur de la morphine, appelé aussi récepteur mu opioïde (µOR) en utilisant des méthodes de pointes de biologie structurale associant la cristallographie aux rayons X et la Résonance Magnétique Nucléaire (RMN). Le récepteur de la morphine est une protéine membranaire de la famille des récepteurs couplés aux protéines G (RCPG) dont le mécanisme de fonctionnement est très peu connu. Ce manque de connaissance est notamment dû aux difficultés que rencontrent les chercheurs pour étudier ces protéines membranaires par des approches de biologie structurale. Cette étude a ainsi fait l'objet d'une publication dans la revue scientifique Nature (Sounier et al., Nature, 524(7565):375-8 -doi: 10.1038/nature14680).

L'étude RMN révèle comment la fixation d'un ligand qui mime la morphine (agoniste) induit des changements d'états conformationnels du µOR d'un état inactif vers un état actif le seul capable de conduire à la transduction du signal intracellulaire via l'activation des protéines de signalisations comme les protéines G. L'étude démontre aussi que cet état actif ne peut être atteint que si l'agoniste et la protéine G sont liés simultanément au récepteur. Cette propriété n'avait été précédemment observée que sur un seul des 800 membres qui composent la famille des RCPG. Ainsi, l'étude révèle comment le signal d'activation se propage à travers les différents domaines du récepteur et propose que ce processus joue un rôle clé dans la transduction du signal. De manière générale, ces données lèvent le voile sur le processus peu connu d'activation des RCPG et de sa dynamique.

Nouvelle publication: "Propagation of conformational changes during μ-opioid receptor activation"
Auteurs: Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S.
Journal: Nature. 2015 Aug 20;524(7565):375-8. doi: 10.1038/nature14680.
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