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Publications
2026
Filtering Disordered Protein Conformations by NMR Residual Dipolar Couplings
Botnari M, Sibille N, Lin JH, Malliavin TE, J Phys Chem B, 2026
DL3D: visual representation of conformational ensembles of domain-linker-domain proteins
Carriere L, Bartels S, Zanon C, Bernado P, Cortes J, BMC Bioinformatics, 2026
LinkCraft: An interactive tool for the design of flexible linkers
Pajkos M, Barrera P, Clerc I, Zanon C, Bernado P, Cortes J, J Mol Biol, 2026
Membrane cholesterol modulates engagement of beta-arrestin with the ghrelin receptor
Berto L, Henri P, Damian M, Cantel S, Fehrentz JA, Sibille N, Di Michele M, Baneres JL, Commun Biol, 2026
Toward a unified framework for determining conformational ensembles of disordered proteins
Ghafouri H, Kaderavek P, Melo AM, Aspromonte MC, Bernado P, Cortes J, Dosztanyi Z, Erdos G, Feig M, Janson G, Lindorff-Larsen K, Mulder FAA, Nagy P, Pestell R, Piovesan D, Schiavina M, Schuler B, Sibille N, Tesei G, Tompa P, Vendruscolo M, Vondrasek J, Vranken W, Zidek L, Tosatto SCE, Monzon AM, Nat Methods, 2026
Programming the Optoelectronic Properties of Atomically Precise Gold Nanoclusters Using the Conformational Landscape of Intrinsically Disordered Proteins
Rodriguez S, Kumanski S, Ayed Z, Fournet A, Bouanchaud C, Sagar A, Allemand F, Baulin VA, Resch-Genger U, Cortes J, Sibille N, Chirot F, Wegner KD, Antoine R, Le Guevel X, Bernado P, Chemistry, 2026
Radiation-response in Deinococcusbacteria: characterization of the transient IrrE-DdrO heterodimer complex
Reuzeau A, Reille O, Malesinski S, Allemand F, Barre T, Lemaire D, Sibille N, de Groot A, Blanchard L, FEMS Microbes, 2026
2025
New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators
Tambones I, Sagar A, Vankova P, Loginov D, Carivenc C, Rochel N, Bourguet W, Man P, Bernado P, le Maire A, Nucleic Acids Res, 2025
Neutral peptides allow aggregation of cationic peptides in antimicrobial secretory fluids
Petkov P, Marinova R, Litov L, Sirakova P, Lilkova E, Kamburova K, Krachmarova E, Taneva S, Allemand F, Mouhand A, Thureau A, Sibille N, Ilieva N, Biochem Biophys Res Commun, 2025
Sequence- and Docking-Site-Dependent Contributions to Multi-Site Phosphorylation of an Intrinsically Disordered MAPK Substrate
Orand T, Delaforge E, Chenal M, Tengo M, Herrmann T, Cortes J, Bernado P, Jensen MR, Adv Sci (Weinh), 2025
The dependence of the amino acid backbone conformation on the translated synonymous codon is not statistically significant
Gonzalez-Delgado J, Mier P, Bernado P, Neuvial P, Cortes J, Proc Natl Acad Sci U S A, 2025
Lipids modulate the dynamics of GPCR:beta-arrestin interaction
Gomes AAS, Di Michele M, Roessner RA, Damian M, Bisch PM, Sibille N, Louet M, Baneres JL, Floquet N, Nat Commun, 2025
KDSAXS: A Tool for Analyzing Binding Equilibria With SAXS Data Using Explicit Models
Gomes T, Ruiz L, Martin-Malpartida P, Bernado P, Baptista AM, Macias MJ, Cordeiro TN, J Mol Biol, 2025
AFflecto: A web server to generate conformational ensembles of flexible proteins from AlphaFold models
Pajkos M, Clerc I, Zanon C, Bernado P, Cortes J, J Mol Biol, 2025
2024
Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues
Elena-Real CA, Urbanek A, Sagar A, Mohanty P, Levy G, Morato A, Fournet A, Allemand F, Sibille N, Mittal J, Sinnaeve D, Bernado P, Chemistry, 2024
Self-Assembled Peptide-Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells
Moro S, Omrani M, Erbek S, Jourdan M, Vandekerckhove CI, Nogier C, Vanwonterghem L, Molina MC, Bernado P, Thureau A, Coll JL, Renaudet O, Le Guevel X, Faure V, Small Sci, 2024
Structure of the aminoterminal domain of the birnaviral multifunctional VP3 protein and its unexplored critical role
Ferrero DS, Gimenez MC, Sagar A, Rodriguez JM, Caston JR, Terebiznik MR, Bernado P, Verdaguer N, PNAS Nexus, 2024
Towards the design of ligands of the internal pocket TEADs C-terminal domain
Toulotte F, Coevoet M, Liberelle M, Bailly F, Zagiel B, Gelin M, Allemand F, Fourquet P, Melnyk P, Guichou JF, Cotelle P, Eur J Med Chem, 2024
Weighted families of contact maps to characterize conformational ensembles of (highly-)flexible proteins
Gonzalez-Delgado J, Bernado P, Neuvial P, Cortes J, Bioinformatics, 2024
A molten globule ensemble primes Arf1-GDP for the nucleotide switch
Koduru T, Hantman N, Peters EV, Jaworek MW, Wang J, Zhang S, McCallum SA, Gillilan RE, Fossat MJ, Roumestand C, Sagar A, Winter R, Bernado P, Cherfils J, Royer CA, Proc Natl Acad Sci U S A, 2024
PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins
Ghafouri H, Lazar T, Del Conte A, Tenorio Ku LG, Tompa P, Tosatto SCE, Monzon AM, Aspromonte MC, Bernado P, Chaves-Arquero B, Chemes LB, Clementel D, Cordeiro TN, Elena-Real CA, Feig M, Felli IC, Ferrari C, Forman-Kay JD, Gomes T, Gondelaud F, Gradinaru CC, Ha-Duong T, Head-Gordon T, Heidarsson PO, Janson G, Jeschke G, Leonardi E, Liu ZH, Longhi S, Lund XL, Macias MJ, Martin-Malpartida P, Mercadante D, Mouhand A, Nagy G, Nugnes MV, Perez-Canadillas JM, Pesce G, Pierattelli R, Piovesan D, Quaglia F, Ricard-Blum S, Robustelli P, Sagar A, Salladini E, Senicourt L, Sibille N, Teixeira JMC, Tsangaris TE, Varadi M, Nucleic Acids Res, 2024
2023
Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration
Fnaiche A, Chan HC, Paquin A, Gonzalez Suarez N, Vu V, Li F, Allali-Hassani A, Cao MA, Szewczyk MM, Bolotokova A, Allemand F, Gelin M, Barsyte-Lovejoy D, Santhakumar V, Vedadi M, Guichou JF, Annabi B, Gagnon A, ACS Med Chem Lett, 2023
A single-domain intrabody targeting the follicle-stimulating hormone receptor impacts FSH-induced G protein-dependent signalling
Raynaud P, Jugnarain V, Vaugrente O, Vallet A, Boulo T, Gauthier C, Inoue A, Sibille N, Gauthier C, Jean-Alphonse F, Reiter E, Crepieux P, Bruneau G, FEBS Lett, 2023
Structure-function relationships in protein homorepeats
Elena-Real CA, Mier P, Sibille N, Andrade-Navarro MA, Bernado P, Curr Opin Struct Biol, 2023
A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation
Valverde JM, Dubra G, Phillips M, Haider A, Elena-Real C, Fournet A, Alghoul E, Chahar D, Andres-Sanchez N, Paloni M, Bernado P, van Mierlo G, Vermeulen M, van den Toorn H, Heck AJR, Constantinou A, Barducci A, Ghosh K, Sibille N, Knipscheer P, Krasinska L, Fisher D, Altelaar M, Nat Commun, 2023
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings
Fnaiche A, Melin L, Suarez NG, Paquin A, Vu V, Li F, Allali-Hassani A, Bolotokova A, Allemand F, Gelin M, Cotelle P, Woo S, LaPlante SR, Barsyte-Lovejoy D, Santhakumar V, Vedadi M, Guichou JF, Annabi B, Gagnon A, Bioorg Med Chem Lett, 2023
Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction
Guillien M, Mouhand A, Sagar A, Fournet A, Allemand F, Pereira GAN, Thureau A, Bernado P, Baneres JL, Sibille N, Structure, 2023
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies
Elena-Real CA, Urbanek A, Imbert L, Morato A, Fournet A, Allemand F, Sibille N, Boisbouvier J, Bernado P, ACS Chem Biol, 2023
Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism
Tarres-Sole A, Battistini F, Gerhold JM, Pietrement O, Martinez-Garcia B, Ruiz-Lopez E, Lyonnais S, Bernado P, Roca J, Orozco M, Le Cam E, Sedman J, Sola M, Nucleic Acids Res, 2023
Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1
Elena-Real CA, Urbanek A, Lund XL, Morato A, Sagar A, Fournet A, Estana A, Bellande T, Allemand F, Cortes J, Sibille N, Melki R, Bernado P, Structure, 2023
WASCO: A Wasserstein-based statistical tool to compare conformational ensembles of intrinsically disordered proteins
Gonzalez-Delgado J, Sagar A, Zanon C, Lindorff-Larsen K, Bernado P, Neuvial P, Cortes J, J Mol Biol, 2023
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
Elena-Real CA, Sagar A, Urbanek A, Popovic M, Morato A, Estana A, Fournet A, Doucet C, Lund XL, Shi ZD, Costa L, Thureau A, Allemand F, Swenson RE, Milhiet PE, Crehuet R, Barducci A, Cortes J, Sinnaeve D, Sibille N, Bernado P, Nat Struct Mol Biol, 2023
2022
The sequence context in poly-alanine regions: structure, function and conservation
Mier P, Elena-Real CA, Cortes J, Bernado P, Andrade-Navarro MA, Bioinformatics, 2022
Disentangling polydisperse biomolecular systems by Chemometrics decomposition of SAS data
Sagar A, Bernado P, Methods Enzymol, 2022
Statistical proofs of the interdependence between nearest neighbor effects on polypeptide backbone conformations
Gonzalez-Delgado J, Bernado P, Neuvial P, Cortes J, J Struct Biol, 2022
eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly
Chaves-Arquero B, Martinez-Lumbreras S, Sibille N, Camero S, Bernado P, Jimenez M, Zorrilla S, Perez-Canadillas JM, Front Mol Biosci, 2022
Structure of the vasopressin hormone-V2 receptor-beta-arrestin1 ternary complex
Bous J, Fouillen A, Orcel H, Trapani S, Cong X, Fontanel S, Saint-Paul J, Lai-Kee-Him J, Urbach S, Sibille N, Sounier R, Granier S, Mouillac B, Bron P, Sci Adv, 2022
Low Complexity Induces Structure in Protein Regions Predicted as Intrinsically Disordered
Goncalves-Kulik M, Mier P, Kastano K, Cortes J, Bernado P, Schmid F, Andrade-Navarro MA, Biomolecules, 2022
Conformational buffering underlies functional selection in intrinsically disordered protein regions
Gonzalez-Foutel NS, Glavina J, Borcherds WM, Safranchik M, Barrera-Vilarmau S, Sagar A, Estana A, Barozet A, Garrone NA, Fernandez-Ballester G, Blanes-Mira C, Sanchez IE, de Prat-Gay G, Cortes J, Bernado P, Pappu RV, Holehouse AS, Daughdrill GW, Chemes LB, Nat Struct Mol Biol, 2022
A flexible and original architecture of two unrelated zinc fingers underlies the role of the multitask P1 in RYMV spread
Poignavent V, Hoh F, Terral G, Yang Y, Gillet FX, Kim JH, Allemand F, Lacombe E, Brugidou C, Cianferani S, Demene H, Vignols F, J Mol Biol, 2022
Tailoring the NIR-II Photoluminescence of Single Thiolated Au25Nanoclusters by Selective Binding to Proteins
Bertorelle F, Wegner KD, Peri Bakuli M, Fakhouri H, Comby-Zerbino C, Sagar A, Bernado P, Resch-Genger U, Bonaci-Kouteck V, Le Guevel X, Antoine R, Chemistry, 2022
Structural Insights into the Intrinsically Disordered GPCR C-Terminal Region, Major Actor in Arrestin-GPCR Interaction
Guillien M, Mouhand A, Fournet A, Gontier A, Marti Navia A, Cordeiro TN, Allemand F, Thureau A, Baneres JL, Bernado P, Sibille N, Biomolecules, 2022
Toward the Design of Ligands Selective for the C-Terminal Domain of TEADs
Liberelle M, Toulotte F, Renault N, Gelin M, Allemand F, Melnyk P, Guichou JF, Cotelle P, J Med Chem, 2022
Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation
Corsini PM, Wang S, Rehman S, Fenn K, Sagar A, Sirovica S, Cleaver L, Edwards-Gayle CJC, Mastroianni G, Dorgan B, Sewell LM, Lynham S, Iuga D, Franks WT, Jarvis J, Carpenter GH, Curtis MA, Bernado P, Darbari VC, Garnett JA, NPJ Biofilms Microbiomes, 2022
A FRET-Based Biosensor for the Src N-Terminal Regulatory Element
Iruela G, Fernandez A, Sagar A, Carvajal FJ, Bernado P, Pons M, Biosensors (Basel), 2022
2021
delta133p53beta isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
Arsic N, Slatter T, Gadea G, Villain E, Fournet A, Kazantseva M, Allemand F, Sibille N, Seveno M, de Rossi S, Mehta S, Urbach S, Bourdon JC, Bernado P, Kajava AV, Braithwaite A, Roux P, Nat Commun, 2021
Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors
Sturbaut M, Bailly F, Coevoet M, Sileo P, Pugniere M, Liberelle M, Magnez R, Thuru X, Chartier-Harlin MC, Melnyk P, Gelin M, Allemand F, Guichou JF, Cotelle P, Eur J Med Chem, 2021
Design, Synthesis and Evaluation of a Series of 1,5-Diaryl-1,2,3-triazole-4-carbohydrazones as Inhibitors of the YAP-TAZ/TEAD Complex
Gibault F, Sturbaut M, Coevoet M, Pugniere M, Burtscher A, Allemand F, Melnyk P, Hong W, Rubin BP, Pobbati AV, Guichou JF, Cotelle P, Bailly F, ChemMedChem, 2021
The diversity of molecular interactions involving intrinsically disordered proteins: A molecular modeling perspective
Clerc I, Sagar A, Barducci A, Sibille N, Bernado P, Cortes J, Comput Struct Biotechnol J, 2021
Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets
Sagar A, Herranz-Trillo F, Langkilde AE, Vestergaard B, Bernado P, Structure, 2021
An integrative structural biology analysis of von Willebrand factor binding and processing by ADAMTS-13 in solution
Del Amo-Maestro L, Sagar A, Pompach P, Goulas T, Scavenius C, Ferrero DS, Castrillo-Briceno M, Taules M, Enghild JJ, Bernado P, Xavier Gomis-Ruth F, J Mol Biol, 2021
Comment on the Optimal Parameters to Derive Intrinsically Disordered Protein Conformational Ensembles from Small-Angle X-ray Scattering Data Using the Ensemble Optimization Method
Sagar A, Jeffries CM, Petoukhov MV, Svergun DI, Bernado P, J Chem Theory Comput, 2021
Interdomain linkers tailor the stability of immunoglobulin repeats in polyproteins
Joshi T, Garg S, Estana A, Cortes J, Bernado P, Das S, Kammath AR, Sagar A, Rakshit S, Biochem Biophys Res Commun, 2021
Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR)
Senicourt L, le Maire A, Allemand F, Carvalho JE, Guee L, Germain P, Schubert M, Bernado P, Bourguet W, Sibille N, J Mol Biol, 2021
PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins
Lazar T, Martinez-Perez E, Quaglia F, Hatos A, Chemes LB, Iserte JA, Mendez NA, Garrone NA, Saldano TE, Marchetti J, Rueda AJV, Bernado P, Blackledge M, Cordeiro TN, Fagerberg E, Forman-Kay JD, Fornasari MS, Gibson TJ, Gomes GW, Gradinaru CC, Head-Gordon T, Jensen MR, Lemke EA, Longhi S, Marino-Buslje C, Minervini G, Mittag T, Monzon AM, Pappu RV, Parisi G, Ricard-Blum S, Ruff KM, Salladini E, Skepo M, Svergun D, Vallet SD, Varadi M, Tompa P, Tosatto SCE, Piovesan D, Nucleic Acids Res, 2021
2020
Robust Cell-Free Expression of Sub-Pathological and Pathological Huntingtin Exon-1 for NMR Studies. General Approaches for the Isotopic Labeling of Low-Complexity Proteins
Morato A, Elena-Real CA, Popovic M, Fournet A, Zhang K, Allemand F, Sibille N, Urbanek A, Bernado P, Biomolecules, 2020
Predicting Secondary Structure Propensities in IDPs Using Simple Statistics from Three-Residue Fragments
Estana A, Barozet A, Mouhand A, Vaisset M, Zanon C, Fauret P, Sibille N, Bernado P, Cortes J, J Mol Biol, 2020
Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins
Urbanek A, Popovic M, Morato A, Estana A, Elena-Real CA, Mier P, Fournet A, Allemand F, Delbecq S, Andrade-Navarro MA, Cortes J, Sibille N, Bernado P, Structure, 2020
Evidence of the Reduced Abundance of Proline cis Conformation in Protein Poly Proline Tracts
Urbanek A, Popovic M, Elena-Real CA, Morato A, Estana A, Fournet A, Allemand F, Gil AM, Cativiela C, Cortes J, Jimenez AI, Sibille N, Bernado P, J Am Chem Soc, 2020
Integrative Biophysics: Protein Interaction and Disorder
Yang S, Bernado P, J Mol Biol, 2020
Disentangling the complexity of low complexity proteins
Mier P, Paladin L, Tamana S, Petrosian S, Hajdu-Soltesz B, Urbanek A, Gruca A, Plewczynski D, Grynberg M, Bernado P, Gaspari Z, Ouzounis CA, Promponas VJ, Kajava AV, Hancock JM, Tosatto SCE, Dosztanyi Z, Andrade-Navarro MA, Brief Bioinformatics, 2020
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3
de Las Rivas M, Paul Daniel EJ, Narimatsu Y, Companon I, Kato K, Hermosilla P, Thureau A, Ceballos-Laita L, Coelho H, Bernado P, Marcelo F, Hansen L, Maeda R, Lostao A, Corzana F, Clausen H, Gerken TA, Hurtado-Guerrero R, Nat Chem Biol, 2020
IDPs and their complexes in GPCR and nuclear receptor signaling
Guillien M, le Maire A, Mouhand A, Bernado P, Bourguet W, Baneres JL, Sibille N, Prog Mol Biol Transl Sci, 2020
Structural Characterization of Protein-Protein Interactions with pyDockSAXS
Jimenez-Garcia B, Bernado P, Fernandez-Recio J, Methods Mol Biol, 2020
The importance of definitions in the study of polyQ regions: A tale of thresholds, impurities and sequence context
Mier P, Elena-Real C, Urbanek A, Bernado P, Andrade-Navarro MA, Comput Struct Biotechnol J, 2020
Structural Analyses of Intrinsically Disordered Proteins by Small-Angle X-Ray Scattering
Sagar A, Svergun D, Bernado P, Methods Mol Biol, 2020
2019
Site-Specific Isotopic Labeling (SSIL) - Access to High-Resolution Structural and Dynamic Information in Low Complexity Proteins
Urbanek A, Elena-Real CA, Popovic M, Morato A, Fournet A, Allemand F, Delbecq S, Sibille N, Bernado P, Chembiochem, 2019
Small-molecule inhibitors of cyclophilins block opening of the mitochondrial permeability transition pore and protect mice from hepatic ischemia-reperfusion injury
Panel M, Ruiz I, Brillet R, Lafdil F, Teixeira-Clerc F, Nguyen CT, Calderaro J, Gelin M, Allemand F, Guichou JF, Ghaleh B, Ahmed-Belkacem A, Morin D, Pawlotsky JM, Gastroenterology, 2019
Double Monoubiquitination Modifies the Molecular Recognition Properties of p15
Gonzalez-Magana A, de Opakua AI, Merino N, Monteiro H, Diercks T, Murciano-Calles J, Luque I, Bernado P, Cordeiro TN, Biasio A, Blanco FJ, ACS Chem Biol, 2019
Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernado P, Structure, 2019
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
Orellana L, Thorne AH, Lema R, Gustavsson J, Parisian AD, Hospital A, Cordeiro TN, Bernado P, Scott AM, Brun-Heath I, Lindahl E, Cavenee WK, Furnari FB, Orozco M, Proc Natl Acad Sci USA, 2019
Investigating the Formation of Structural Elements in Proteins Using Local Sequence-Dependent Information and a Heuristic Search Algorithm
Estana A, Ghallab M, Bernado P, Cortes J, Molecules, 2019
Realistic Ensemble Models of Intrinsically Disordered Proteins Using a Structure-Encoding Coil Database
Estana A, Sibille N, Delaforge E, Vaisset M, Cortes J, Bernado P, Structure, 2019
2018
Hybrid parallelization of a multi-tree path search algorithm: Application to highly-flexible biomolecules
Estana A, Molloy K, Vaisset M, Sibille S, Simeon T, Bernado P, Cortes J, Parallel computing, 2018
Protein Flexibility and Synergy of HMG Domains Underlie U-Turn Bending of DNA by TFAM in Solution
Rubio-Cosials A, Battistini F, Gansen A, Cuppari A, Bernado P, Orozco M, Langowski J, Toth K, Sola M, Biophys J, 2018
Toward the Discovery of a Novel Class of YAPaTEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAPaTEAD ProteinaProtein Interface
Gibault F, Coevoet M, Sturbaut M, Farce A, Renault N, Allemand F, Guichou JF, Drucbert AS, Foulon C, Magnez R, Thuru X, Corvaisier M, Huet G, Chavatte P, Melnyk P, Bailly F, Cotelle P, Cancers (Basel), 2018
Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation
Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S, Structure, 2018
A General Strategy to Access Structural Information at Atomic Resolution in Polyglutamine Homorepeats
Urbanek A, Morato A, Allemand F, Delaforge E, Fournet A, Popovic M, Delbecq S, Sibille N, Bernado P, Angew Chem Int Ed Engl, 2018
Solution scattering approaches to dynamical ordering in biomolecular systems
Bernado P, Shimizu N, Zaccai G, Kamikubo H, Sugiyama M, Biochim Biophys Acta, 2018
A General Strategy to Access Atomic Resolution Structural Information in Poly-Glutamine Homo-Repeats
Bernado P, Urbanek A, Morato A, Allemand F, Delaforge E, Fournet A, Popovic M, Delbecq S, Sibille N, Angew Chem Int Ed Engl, 2018
Noninvasive Structural Analysis of Intermediate Species During Fibrillation: An Application of Small-Angle X-Ray Scattering
Langkilde AE, Herranz-Trillo F, Bernado P, Vestergaard B, Methods Mol Biol, 2018
2017
Disulfide driven folding for a conditionally disordered protein
Fraga H, Pujols J, Gil-Garcia M, Roque A, Bernardo-Seisdedos G, Santambrogio C, Bech-Serra JJ, Canals F, Bernado P, Grandori R, Millet O, Ventura S, Sci Rep, 2017
The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases
Arbesu M, Maffei M, Cordeiro TN, Teixeira JM, Perez Y, Bernado P, Roche S, Pons M, Structure, 2017
Disentangling polydispersity in the PCNA-p15PAF complex, a disordered, transient and multivalent macromolecular assembly
Cordeiro TN, Chen PC, De Biasio A, Sibille N, Blanco FJ, Hub JS, Crehuet R, Bernado P, Nucleic Acids Res, 2017
Small-angle scattering studies of intrinsically disordered proteins and their complexes
Cordeiro TN, Herranz-Trillo F, Urbanek A, Estana A, Cortes J, Sibille N, Bernado P, Curr Opin Struct Biol, 2017
Structural Analysis of Multi-component Amyloid Systems by Chemometric SAXS Data Decomposition
Herranz-Trillo F, Groenning M, van Maarschalkerweerd A, Tauler R, Vestergaard B, Bernado P, Structure, 2017
Conformational Characterization of Intrinsically Disordered Proteins and Its Biological Significance
Delaforge E, Cordeiro TN, Bernado P, Sibille N, Modern Magnetic Resonance, 2017
Structural Characterization of Highly Flexible Proteins by Small-Angle Scattering
Cordeiro TN, Herranz-Trillo F, Urbanek A, Estana A, Cortes J, Sibille N, Bernado P, Adv Exp Med Biol, 2017
The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil
Ibanez de Opakua A, Merino N, Villate M, Cordeiro TN, Ormaza G, Sanchez-Carbayo M, Diercks T, Bernado P, Blanco FJ, PLoS ONE, 2017
2016
Epithelial Splicing Regulatory Protein 1 (ESRP1) is a new regulator of stomach smooth muscle development and plasticity
Sagnol S, Marchal S, Yang Y, Allemand F, de Stanta Barba P, Dev Biol, 2016
Ensemble Structure of the Highly Flexible Complex Formed between Vesicular Stomatitis Virus Unassembled Nucleoprotein and its Phosphoprotein Chaperone
Yabukarksi F, Leyrat C, Martinez N, Communie G, Ivanov I, Ribeiro EA, Buisson M, Gerard FC, Bourhis JM, Jensen MR, Bernado P, Blackledge M, Jamin M, J Mol Biol, 2016
Ensemble Structure of the Highly Flexible Complex Formed between Vesicular Stomatitis Virus Unassembled Nucleoprotein and its Phosphoprotein Chaperone
Yabukarski F, Leyrat C, Martinez N, Communie G, Ivanov I, Ribeiro EA, Buisson M, Gerard FC, Bourhis JM, Jensen MR, Bernado P, Blackledge M, Jamin M, J Mol Biol, 2016
Active Site-Directed Inhibitors of Prolyl Oligopeptidase Abolishes its Conformational Dynamics
Lopez A, Herranz-Trillo F, Kotev M, Gairi M, Guallar V, Bernado P, Millet O, Tarrago T, Giralt E, Chembiochem, 2016
2015
Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography
Gelin M, Delfosse V, Allemand F, Hoh F, Sallaz-Damaz Y, Pirocchi M, Bourguet W, Ferrer JL, Labesse G, Guichou JF, Acta Crystallogr D Biol Crystallogr, 2015
Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation
Lira-Navarrete E, de Las Rivas M, Companon I, Pallares MC, Kong Y, Iglesias-Fernandez J, Bernardes GJ, Peregrina JM, Rovira C, Bernado P, Bruscolini P, Clausen H, Lostao A, Corzana F, Hurtado-Guerrero R, Nat Commun, 2015
pyDockSAXS: protein-protein complex structure by SAXS and computational docking
Jimenez-Garcia B, Pons C, Svergun DI, Bernado P, Fernandez-Recio J, Nucleic Acids Res, 2015
Structure of p15(PAF)-PCNA complex and implications for clamp sliding during DNA replication and repair
De Biasio A, de Opakua AI, Mortuza GB, Molina R, Cordeiro TN, Castillo F, Villate M, Merino N, Delgado S, Gil-Carton D, Luque I, Diercks T, Bernado P, Montoya G, Blanco FJ, Nat Commun, 2015
A Three-protein Charge Zipper Stabilizes a Complex Modulating Bacterial Gene Silencing
Cordeiro TN, Garcia J, Bernado P, Millet O, Pons M, J Biol Chem, 2015
The hexameric structure of the human mitochondrial replicative helicase Twinkle
Fernandez-Millan P, Lazaro M, Cans1z-Arda S, Gerhold JM, Rajala N, Schmitz CA, Silva-Espina C, Gil D, Bernado P, Valle M, Spelbrink JN, Sola M, Nucleic Acids Res, 2015
Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution
Bianchin A, Allemand F, Bell A, Chubb AJ, Guichou JF, Acta Crystallogr D Biol Crystallogr, 2015
2014
p15(PAF) Is an Intrinsically Disordered Protein with Nonrandom Structural Preferences at Sites of Interaction with Other Proteins
De Biasio A, Ibanez de Opakua A, Cordeiro TN, Villate M, Merino N, Sibille N, Lelli M, Diercks T, Bernado P, Blanco FJ, Biophys J, 2014
(1)H, (15)N and (13)C Backbone resonance assignments of murine met-neuroglobin, free and in complex with cyanide
Yang Y, Allemand F, Guca E, Vallone B, Delbecq S, Roumestand C, Biomol NMR Assign, 2014
Chromatin Insulator Factors Involved in Long-Range DNA Interactions and Their Role in the Folding of the Drosophila Genome
Vogelmann J, Le Gall A, Dejardin S, Allemand F, Gamot A, Labesse G, Cuvier O, Negre N, Cohen-Gonsaud M, Margeat E, Nollmann M, PLoS Genet, 2014
Multiple Stable Conformations Account for Reversible Concentration-Dependent Oligomerization and Autoinhibition of a Metamorphic Metallopeptidase
Lopez-Pelegrin M, Cerda-Costa N, Cintas-Pedrola A, Herranz-Trillo F, Bernado P, Peinado JR, Arolas JL, Gomis-Ruth FX, Angew Chem Int Ed Engl, 2014
Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity
Sagnol S, Yang Y, Bessin Y, Allemand F, Hapkova I, Notarnicola C, Guichou JF, Faure S, Labesse G, de Santa Barbara P, Nucleic Acids Res, 2014
2013
Hinged plakin domains provide specialized degrees of articulation in envoplakin, periplakin and desmoplakin
Al-Jassar C, Bernado P, Chidgey M, Overduin M, PLoS One, 2013
Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism
Perez Y, Maffei M, Igea A, Amata I, Gairi M, Nebreda AR, Bernado P, Pons M, Sci Rep, 2013
Conformational transitions in human translin enable nucleic acid binding
Perez-Cano L, Eliahoo E, Lasker K, Wolfson HJ, Glaser F, Manor H, Bernado P, Fernandez-Recio J, Nucleic Acids Res, 2013
Measuring residual dipolar couplings at high hydrostatic pressure: robustness of alignment media to high pressure
Sibille N, Dellarole M, Royer C, Roumestand C, J Biomol NMR, 2013
2012
Low concentration of a Gd-chelate increases the signal-to-noise ratio in fast pulsing BEST experiments.
Sibille N, Bellot G, Wang J, Demene H, J. Magn. Reson., 2012
Defining the nature of thermal intermediate in 3 state folding proteins: apoflavodoxin, a study case
Garcia-Fandino R, Bernado P, Ayuso-Tejedor S, Sancho J, Orozco M, PLoS Comput Biol, 2012
Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein
Sibille N, Huvent I, Fauquant C, Verdegem D, Amniai L, Leroy A, Wieruszeski JM, Lippens G, Landrieu I, Proteins, 2012
Structural characterization of intrinsically disordered proteins by the combined use of NMR and SAXS.
Sibille N, Bernado P, Biochem. Soc. Trans., 2012
Measurement and analysis of NMR residual dipolar couplings for the study of intrinsically disordered proteins
Salmon L, Jensen MR, Bernado P, Blackledge M, Methods Mol Biol, 2012
Flexible-meccano: a tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables.
Ozenne V, Bauer F, Salmon L, Huang JR, Jensen MR, Segard S, Bernado P, Charavay C, Blackledge M, Bioinformatics, 2012
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering.
Bernado P, Svergun DI, Mol Biosyst, 2012
Analysis of intrinsically disordered proteins by small-angle X-ray scattering
Bernado P, Svergun DI, Methods Mol Biol, 2012
2011
| Directeur | Emmanuel Margeat |
| Directeurs adjoints | Vanessa Delfosse Martin Cohen-Gonsaud |
| Resp.Admin. | Florence Lepage |
| (33) 04 67 41 79 01 |
| Assist.Gest. | Marion Boutin |
| (33) 04 67 41 79 04 |
| Contact | (33) 04 67 41 79 04 |
