Plateforme Intégrée de Biophysique et de Biologie Structurale


Mechanical properties


Evaluation of mechanical properties of biomolecules and cells.

The technique allows characterizing the mechanical properties of the sample at high spatial resolution by means of Force Spectroscopy, Quantitative-Imaging or Peak-Force Tapping. Making use of the AFM tip as a nanometric indenter, we can characterize the extrinsic and, if possible, the intrinsic rigidity of materials with high spatial resolution.


Left: DOPC-DPPC (1:1) model membrane morphology. Right: corresponding Young modulus evaluated modeling the tip-sample mechanical contact with the Hertz theory.


Correlative AFM with Super-Resolution Fluorescence, TIRF and EPI


Correlative AFM with Fluorescence Spectroscopy


High-Speed Atomic Force Microscopy


Multimode equipped with Nanoscope VIII (BRUKER)

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X-AFM: AFM that can be installed in Synchrotron X-Ray beamlines.


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