Structural biology

Structural Biology

Welcome to the department of Structural Biology at the CBS.

The department of Structural Biology comprises five teams that make use of a wide array of cutting-edge technologies to gain insight into biological phenomena at the molecular and atomic level. The approaches being used and developed include X-ray crystallography, electron microscopy (EM), nuclear magnetic resonance (NMR), small angle X-ray scattering (SAXS), computational modeling, chemistry, and synthetic biology.

	Structure, function and dynamics of biomolecules by NMR Structural biology of infectious diseases, high pressure NMR and protein folding Christian Roumestand
	Highly flexible protein Deciphering the links between the structure and dynamics of disordered proteins with their biological function Pau Bernadó
	Multi-scale structural biology Investigating the structure of biological complexes of pathogens in using integrated structural methods Patrick Bron
	Synthetic biology Rational design of new biological systems and translating synthetic biology tools and principles to healthcare and medical diagnostics Jérôme Bonnet
	Structures and screening of therapeutic and environmental targets Characterization of therapeutic and environmental targets, focused medicinal chemistry and integrated screening by X-ray crystallography and bioinformatics William Bourguet

Admin.Resp.	Florence Lepage
	(33) 04 67 41 79 04

Admin.Resp.	Didier Debain
	(33) 04 67 41 79 01

Manager.Assist.	Marion Boutin
	(33) 04 67 41 79 04

Centre de Biologie Structurale

Latest publications

1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM

Hi-M: A Multiplex Oligopaint FISH Method to Capture Chromatin Conformations In Situ and Accompanying Open-Source Acquisition Software

Emergence of slip-ideal-slip behavior in tip-links serve as force filters of sound in hearing

Increases in cyclin A/Cdk activity and in PP2A-B55 inhibition by FAM122A are key mitosis-inducing events

pyHiM: a new open-source, multi-platform software package for spatial genomics based on multiplexed DNA-FISH imaging

LactoSpanks: A Collection of IPTG Inducible Promoters for the Commensal Lactic Acid Bacteria Lactobacillus gasseri

PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins

An innovative in situAFM system for a soft X-ray spectromicroscopy synchrotron beamline

Critical micellar concentration determination of pure phospholipids and lipid-raft and their mixtures with cholesterol

Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric alphaD pocket

Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds

Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration

The genome of a bunyavirus cannot be defined at the level of the viral particle but only at the scale of the viral population

A single-domain intrabody targeting the follicle-stimulating hormone receptor impacts FSH-induced G protein-dependent signalling

Structure-function relationships in protein homorepeats

3D chromatin interactions involving Drosophila insulators are infrequent but preferential and arise before TADs and transcription

A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation

wTSA-CRAFT: an open-access web server for rapid analysis of thermal shift assay experiments

Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings

Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae

Multi-scale dynamic imaging reveals that cooperative motility behaviors promote efficient predation in bacteria

Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction

The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia-reperfusion injury via mitoprotection

Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies

Does a Similar 3D Structure Mean a Similar Folding Pathway? The Presence of a C-Terminal alpha-Helical Extension in the 3D Structure of MAX60 Drastically Changes the Folding Pathway Described for Other MAX-Effectors from Magnaporthe oryzae

Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs

Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins

Isothermal self-assembly of multicomponent and evolutive DNA nanostructures

Structure, dynamics and transferability of the metal-dependent polyhistidine tetramerization motif TetrHis for single-chain Fv antibodies

Linkers in fragment-based drug design: an overview of the literature

Structural Biology

CBS Teams

Structure, Dynamics and Function of biomolecules by NMR

Structure and function of highly flexible proteins

Multi-scale structural biology

ABCIS

Nuclear Receptors as Integrators of Endogenous and Environmental Signals

Mechanisms of DNA Segregation and Remodelling

Physics and mechanics of biological systems

Integrative Biophysics of Membranes

Multiscale Biomolecular Modeling

Synthetic Biology

Chromosome structure and homologous recombination in meiosis

Functional and synthetic genomics

Structure and function of the aryl hydrocarbon receptor

Postdoctoral position – Team Integrative Biophysics of Membranes

Postdoctoral position – Team Integrative Biophysics of Membranes

Connexion