| Service |
HP NMR and screening
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| Goal |
Folding pathway of proteins at the residue level. Ligand screening at low throughput. |
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Series of HSQC spectra are recorded at increasing hydrostatic pressure.
Thermodynamic analysis allows characterizing the unfolding/folding pathway.
Output : Series of thermodynamic parameters and intermediate structures. |
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| Equipement |
700 MHz NMR spectrometer
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600 MHz NMR spectrometer
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