Important implication of intrinsically disordered protein in signaling pathways

Cellular signaling machinery is involved in major physiological processes and therefore in a large number of diseases. However, full understanding of these complex systems function and deregulation, in a physiopathological context, is made difficult by the presence of a large number of disordered regions. Their structural and functional properties are still largely unexplored. In this chapter, we present the signaling pathways of G protein-coupled receptors and those of nuclear receptors. We describe the involvement of these disordered regions of the different actors which are at the heart of the action mechanism.


Myriam Guillien, Albane le Maire, Assia Mouhand, William Bourguet, Jean-LouisBanères, Nathalie Sibille*


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