Nathalie Sibille
Structure et fonction de protéines hautement flexibles
04 67 41 77 05
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Liste des publications
2024
Site-Specific Incorporation of Fluorinated Prolines into Proteins and their Impact on Neighbouring Residues
Elena-Real CA, Urbanek A, Sagar A, Mohanty P, Levy G, Morato A, Fournet A, Allemand F, Sibille N, Mittal J, Sinnaeve D, Bernado P, Chemistry, 2024
PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins
Ghafouri H, Lazar T, Del Conte A, Tenorio Ku LG, Tompa P, Tosatto SCE, Monzon AM, Aspromonte MC, Bernado P, Chaves-Arquero B, Chemes LB, Clementel D, Cordeiro TN, Elena-Real CA, Feig M, Felli IC, Ferrari C, Forman-Kay JD, Gomes T, Gondelaud F, Gradinaru CC, Ha-Duong T, Head-Gordon T, Heidarsson PO, Janson G, Jeschke G, Leonardi E, Liu ZH, Longhi S, Lund XL, Macias MJ, Martin-Malpartida P, Mercadante D, Mouhand A, Nagy G, Nugnes MV, Perez-Canadillas JM, Pesce G, Pierattelli R, Piovesan D, Quaglia F, Ricard-Blum S, Robustelli P, Sagar A, Salladini E, Senicourt L, Sibille N, Teixeira JMC, Tsangaris TE, Varadi M, Nucleic Acids Res, 2024
2023
A single-domain intrabody targeting the follicle-stimulating hormone receptor impacts FSH-induced G protein-dependent signalling
Raynaud P, Jugnarain V, Vaugrente O, Vallet A, Boulo T, Gauthier C, Inoue A, Sibille N, Gauthier C, Jean-Alphonse F, Reiter E, Crepieux P, Bruneau G, FEBS Lett, 2023
Structure-function relationships in protein homorepeats
Elena-Real CA, Mier P, Sibille N, Andrade-Navarro MA, Bernado P, Curr Opin Struct Biol, 2023
A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation
Valverde JM, Dubra G, Phillips M, Haider A, Elena-Real C, Fournet A, Alghoul E, Chahar D, Andres-Sanchez N, Paloni M, Bernado P, van Mierlo G, Vermeulen M, van den Toorn H, Heck AJR, Constantinou A, Barducci A, Ghosh K, Sibille N, Knipscheer P, Krasinska L, Fisher D, Altelaar M, Nat Commun, 2023
Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction
Guillien M, Mouhand A, Sagar A, Fournet A, Allemand F, Pereira GAN, Thureau A, Bernado P, Baneres JL, Sibille N, Structure, 2023
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies
Elena-Real CA, Urbanek A, Imbert L, Morato A, Fournet A, Allemand F, Sibille N, Boisbouvier J, Bernado P, ACS Chem Biol, 2023
Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1
Elena-Real CA, Urbanek A, Lund XL, Morato A, Sagar A, Fournet A, Estana A, Bellande T, Allemand F, Cortes J, Sibille N, Melki R, Bernado P, Structure, 2023
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
Elena-Real CA, Sagar A, Urbanek A, Popovic M, Morato A, Estana A, Fournet A, Doucet C, Lund XL, Shi ZD, Costa L, Thureau A, Allemand F, Swenson RE, Milhiet PE, Crehuet R, Barducci A, Cortes J, Sinnaeve D, Sibille N, Bernado P, Nat Struct Mol Biol, 2023
2022
eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly
Chaves-Arquero B, Martinez-Lumbreras S, Sibille N, Camero S, Bernado P, Jimenez M, Zorrilla S, Perez-Canadillas JM, Front Mol Biosci, 2022
Structure of the vasopressin hormone-V2 receptor-beta-arrestin1 ternary complex
Bous J, Fouillen A, Orcel H, Trapani S, Cong X, Fontanel S, Saint-Paul J, Lai-Kee-Him J, Urbach S, Sibille N, Sounier R, Granier S, Mouillac B, Bron P, Sci Adv, 2022
Structural Insights into the Intrinsically Disordered GPCR C-Terminal Region, Major Actor in Arrestin-GPCR Interaction
Guillien M, Mouhand A, Fournet A, Gontier A, Marti Navia A, Cordeiro TN, Allemand F, Thureau A, Baneres JL, Bernado P, Sibille N, Biomolecules, 2022
2021
delta133p53beta isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
Arsic N, Slatter T, Gadea G, Villain E, Fournet A, Kazantseva M, Allemand F, Sibille N, Seveno M, de Rossi S, Mehta S, Urbach S, Bourdon JC, Bernado P, Kajava AV, Braithwaite A, Roux P, Nat Commun, 2021
The diversity of molecular interactions involving intrinsically disordered proteins: A molecular modeling perspective
Clerc I, Sagar A, Barducci A, Sibille N, Bernado P, Cortes J, Comput Struct Biotechnol J, 2021
Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR)
Senicourt L, le Maire A, Allemand F, Carvalho JE, Guee L, Germain P, Schubert M, Bernado P, Bourguet W, Sibille N, J Mol Biol, 2021
2020
Robust Cell-Free Expression of Sub-Pathological and Pathological Huntingtin Exon-1 for NMR Studies. General Approaches for the Isotopic Labeling of Low-Complexity Proteins
Morato A, Elena-Real CA, Popovic M, Fournet A, Zhang K, Allemand F, Sibille N, Urbanek A, Bernado P, Biomolecules, 2020
Predicting Secondary Structure Propensities in IDPs Using Simple Statistics from Three-Residue Fragments
Estana A, Barozet A, Mouhand A, Vaisset M, Zanon C, Fauret P, Sibille N, Bernado P, Cortes J, J Mol Biol, 2020
Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins
Urbanek A, Popovic M, Morato A, Estana A, Elena-Real CA, Mier P, Fournet A, Allemand F, Delbecq S, Andrade-Navarro MA, Cortes J, Sibille N, Bernado P, Structure, 2020
Evidence of the Reduced Abundance of Proline cis Conformation in Protein Poly Proline Tracts
Urbanek A, Popovic M, Elena-Real CA, Morato A, Estana A, Fournet A, Allemand F, Gil AM, Cativiela C, Cortes J, Jimenez AI, Sibille N, Bernado P, J Am Chem Soc, 2020
IDPs and their complexes in GPCR and nuclear receptor signaling
Guillien M, le Maire A, Mouhand A, Bernado P, Bourguet W, Baneres JL, Sibille N, Prog Mol Biol Transl Sci, 2020
2019
Site-Specific Isotopic Labeling (SSIL) - Access to High-Resolution Structural and Dynamic Information in Low Complexity Proteins
Urbanek A, Elena-Real CA, Popovic M, Morato A, Fournet A, Allemand F, Delbecq S, Sibille N, Bernado P, Chembiochem, 2019
Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernado P, Structure, 2019
Realistic Ensemble Models of Intrinsically Disordered Proteins Using a Structure-Encoding Coil Database
Estana A, Sibille N, Delaforge E, Vaisset M, Cortes J, Bernado P, Structure, 2019
2018
A General Strategy to Access Structural Information at Atomic Resolution in Polyglutamine Homorepeats
Urbanek A, Morato A, Allemand F, Delaforge E, Fournet A, Popovic M, Delbecq S, Sibille N, Bernado P, Angew Chem Int Ed Engl, 2018
A General Strategy to Access Atomic Resolution Structural Information in Poly-Glutamine Homo-Repeats
Bernado P, Urbanek A, Morato A, Allemand F, Delaforge E, Fournet A, Popovic M, Delbecq S, Sibille N, Angew Chem Int Ed Engl, 2018
2017
Disentangling polydispersity in the PCNA-p15PAF complex, a disordered, transient and multivalent macromolecular assembly
Cordeiro TN, Chen PC, De Biasio A, Sibille N, Blanco FJ, Hub JS, Crehuet R, Bernado P, Nucleic Acids Res, 2017
Small-angle scattering studies of intrinsically disordered proteins and their complexes
Cordeiro TN, Herranz-Trillo F, Urbanek A, Estana A, Cortes J, Sibille N, Bernado P, Curr Opin Struct Biol, 2017
Conformational Characterization of Intrinsically Disordered Proteins and Its Biological Significance
Delaforge E, Cordeiro TN, Bernado P, Sibille N, Modern Magnetic Resonance, 2017
Structural Characterization of Highly Flexible Proteins by Small-Angle Scattering
Cordeiro TN, Herranz-Trillo F, Urbanek A, Estana A, Cortes J, Sibille N, Bernado P, Adv Exp Med Biol, 2017
2014
2013
2012
Low concentration of a Gd-chelate increases the signal-to-noise ratio in fast pulsing BEST experiments.
Sibille N, Bellot G, Wang J, Demene H, J. Magn. Reson., 2012
Structural characterization of intrinsically disordered proteins by the combined use of NMR and SAXS.
Sibille N, Bernado P, Biochem. Soc. Trans., 2012
Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein
Sibille N, Huvent I, Fauquant C, Verdegem D, Amniai L, Leroy A, Wieruszeski JM, Lippens G, Landrieu I, Proteins, 2012
2011
2010
NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease
Landrieu I, Leroy A, Smet-Nocca C, Huvent I, Amniai L, Hamdane M, Sibille N, Buee L, Wieruszeski JM, Lippens G, Biochem Soc Trans, 2010
Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025
Landrieu I, Hanoulle X, Bonachera F, Hamel A, Sibille N, Yin Y, Wieruszeski JM, Horvath D, Wei Q, Vuagniaux G, Lippens G, Biochemistry, 2010
2009
2007
Structural and functional characterization of the interaction between cyclophilin B and a heparin-derived oligosaccharide
Hanoulle X, Melchior A, Sibille N, Parent B, Denys A, Wieruszeski JM, Horvath D, Allain F, Lippens G, Landrieu I, J Biol Chem, 2007
Tau aggregation in Alzheimer's disease: what role for phosphorylation?
Lippens G, Sillen A, Landrieu I, Amniai L, Sibille N, Barbier P, Leroy A, Hanoulle X, Wieruszeski JM, Prion, 2007
2006
NMR analysis of a Tau phosphorylation pattern
Landrieu I, Lacosse L, Leroy A, Wieruszeski JM, Trivelli X, Sillen A, Sibille N, Schwalbe H, Saxena K, Langer T, Lippens G, J Am Chem Soc, 2006
Comparative NMR study on the impact of point mutations on protein stability of Pseudomonas mendocina lipase
Sibille N, Favier A, Azuaga AI, Ganshaw G, Bott R, Bonvin AM, Boelens R, van Nuland NA, Protein Sci, 2006
Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopy
Sibille N, Sillen A, Leroy A, Wieruszeski JM, Mulloy B, Landrieu I, Lippens G, Biochemistry, 2006
2005
2002
Reactivity, secondary structure, and molecular topology of the Escherichia coli sulfite reductase flavodoxin-like domain
Champier L, Sibille N, Bersch B, Brutscher B, Blackledge M, Coves J, Biochemistry, 2002
Side chain orientation from methyl 1H-1H residual dipolar couplings measured in highly deuterated proteins
Sibille N, Bersch B, Coves J, Blackledge M, Brutscher B, J Am Chem Soc, 2002
2001
1H, 13C and 15N assignment of the flavodoxin-like domain of the Escherichia coli sulfite reductase
Sibille N, Coves J, Marion D, Brutscher B, Bersch B, J Biomol NMR, 2001
Refinement of local and long-range structural order in theophylline-binding RNA using (13)C-(1)H residual dipolar couplings and restrained molecular dynamics
Sibille N, Pardi A, Simorre JP, Blackledge M, J Am Chem Soc, 2001