Liste des publications

2023

• Retinoic Acid and Retinoid X Receptors

  Schubert M, Germain P, Cells, 2023

2022

• Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

  Gruszczyk J, Grandvuillemin L, Lai-Kee-Him J, Paloni M, Savva CG, Germain P, Grimaldi M, Boulahtouf A, Kwong HS, Bous J, Ancelin A, Bechara C, Barducci A, Balaguer P, Bourguet W, Nat Commun, 2022

• Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids

  le Maire A, Rey M, Vivat V, Guee L, Blanc P, Malosse C, Chamot-Rooke J, Germain P, Bourguet W, J Mol Endocrinol, 2022

• Ligands and DNA in the allosteric control of retinoid receptors function

  Germain P, Rochel N, Bourguet W, Essays Biochem, 2022

2021

• Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR)

  Senicourt L, le Maire A, Allemand F, Carvalho JE, Guee L, Germain P, Schubert M, Bernado P, Bourguet W, Sibille N, J Mol Biol, 2021

2020

• Protein-protein interactions in the regulation of RAR-RXR heterodimers transcriptional activity

  le Maire A, Germain P, Bourguet W, Meth Enzymol, 2020

2019

• Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations

  le Maire A, Teyssier C, Balaguer P, Bourguet W, Germain P, Cells, 2019

• Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression

  Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernado P, Structure, 2019

2018

• Pathological interactions between mutant thyroid hormone receptors and corepressors and their modulation by a thyroid hormone analogue with therapeutic potential

  Harrus D, Demene H, Vasquez EF, Boulahtouf A, Germain P, Figueira AC, Privalsky ML, Bourguet W, le Maire A, Thyroid, 2018

• The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

  Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Kumar Nadendla E, Bertucci PY, Germain P, Tomancak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M, Sci Adv, 2018

2015

• An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RARbeta, NR1B2) Selective Agonist

  Nadendla E, Teyssier C, Delfosse V, Vivat V, Krishnasamy G, Gronemeyer H, Bourguet W, Germain P, PLoS ONE, 2015

2013

• Dimerization of nuclear receptors

  Germain P, Bourguet W, Methods Cell Biol, 2013

2011

• IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data

  Sharman JL, Mpamhanga CP, Spedding M, Germain P, Staels B, Dacquet C, Laudet V, Harmar AJ, Nucleic Acids Res, 2011

2010

• A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

  le Maire A, Teyssier C, Erb C, Grimaldi M, Alvarez S, de Lera AR, Balaguer P, Gronemeyer H, Royer CA, Germain P, Bourguet W, Nat Struct Mol Biol, 2010

2009

• Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists

  Alvarez S, Alvarez R, Khanwalkar H, Germain P, Lemaire G, Rodriguez-Barrios F, Gronemeyer H, de Lera AR, Bioorg Med Chem, 2009

• Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists

  Germain P, Gaudon C, Pogenberg V, Sanglier S, Van Dorsselaer A, Royer CA, Lazar MA, Bourguet W, Gronemeyer H, Chem Biol, 2009

• Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-y l)phenyl]acrylic acids and their 4-alkoxy isomers

  Perez Santin E, Germain P, Quillard F, Khanwalkar H, Rodriguez-Barrios F, Gronemeyer H, de Lera AR, Bourguet W, J Med Chem, 2009

• Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)

  Rochette-Egly C, Germain P, Nucl Recept Signal, 2009

• Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus

  Tocchini-Valentini GD, Rochel N, Escriva H, Germain P, Peluso-Iltis C, Paris M, Sanglier-Cianferani S, Van Dorsselaer A, Moras D, Laudet V, J Biol Chem, 2009

2008

• Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization

  Nahoum V, Lipski A, Quillard F, Guichou JF, Boublik Y, Perez E, Germain P, de Lera AR, Bourguet W, Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008

2007

• Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

  Nahoum V, Perez E, Germain P, Rodriguez-Barrios F, Manzo F, Kammerer S, Lemaire G, Hirsch O, Royer CA, Gronemeyer H, de Lera AR, Bourguet W, Proc Natl Acad Sci U S A, 2007

2005

• Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies

  Pogenberg V, Guichou JF, Vivat-Hannah V, Kammerer S, Perez E, Germain P, de Lera AR, Gronemeyer H, Royer CA, Bourguet W, J Biol Chem, 2005

2004

• Monitoring ligand-mediated nuclear receptor-coregulator interactions by noncovalent mass spectrometry

  Sanglier S, Bourguet W, Germain P, Chavant V, Moras D, Gronemeyer H, Potier N, Van Dorsselaer A, Eur J Biochem, 2004

2003

• Nuclear receptor superfamily: principles of signaling

  Germain P, Altucci L, Bourguet W, Rochette-Egly C, Gronemeyer H, Pure Appl Chem, 2003

2000

• Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

  Bourguet W, Germain P, Gronemeyer H, Trends Pharmacol Sci, 2000

2002

• Signal transduction and structure of nuclear receptors

  Bourguet W, Germain P, Gronemeyer H, Hormone signaling, 2002