Liste des publications

2024

• The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited

  Lahfa M, Barthe P, deGuillen K, Cesari S, Raji M, Kroj T, Le Naour-Vernet M, Hoh F, Gladieux P, Roumestand C, Gracy J, Declerck N, Padilla A, PLoS Pathog, 2024

• 1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM

  Mouhand A, Nakatani K, Kono F, Hippo Y, Matsuo T, Barthe P, Peters J, Suenaga Y, Tamada T, Roumestand C, Biomol NMR Assign, 2024

2023

• Does a Similar 3D Structure Mean a Similar Folding Pathway? The Presence of a C-Terminal alpha-Helical Extension in the 3D Structure of MAX60 Drastically Changes the Folding Pathway Described for Other MAX-Effectors from Magnaporthe oryzae

  Lahfa M, Mouhand A, deGuillen K, Barthe P, Kroj T, Padilla A, Roumestand C, Molecules, 2023

• 1H, 13C and 15N backbone and side-chain resonance assignments of BmSA1, the surface antigen of Babesia microti

  Mouhand A, Pissarra J, Delbecq S, Roumestand C, Barthe P, Biomol NMR Assign, 2023

• A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome cExit

  Martin M, deVisch A, Boudehen YM, Barthe P, Gutierrez C, Turapov O, Aydogan T, Heriaud L, Gracy J, Neyrolles O, Mukamolova GV, Letourneur F, Cohen-Gonsaud M, Microbiol Spectr, 2023

2022

• PYK2 senses calcium through a disordered dimerization and calmodulin-binding element

  Momin AA, Mendes T, Barthe P, Faure C, Hong S, Yu P, Kadare G, Jaremko M, Girault JA, Jaremko , Arold ST, Commun Biol, 2022

• 1H, 13C, 15N backbone and side-chain NMR assignments for three MAX effectors from Magnaporthe oryzae

  Lahfa M, Padilla A, deGuillen K, Pissarra J, Raji M, Cesari S, Kroj T, Gladieux P, Roumestand C, Barthe P, Biomol NMR Assign, 2022

• Combining High-Pressure NMR and Geometrical Sampling to Obtain a Full Topological Description of Protein Folding Landscapes: Application to the Folding of Two MAX Effectors from Magnaporthe oryzae

  Dubois C, Lahfa M, Pissarra J, deGuillen K, Barthe P, Kroj T, Roumestand C, Padilla A, Int J Mol Sci, 2022

2021

• Comparative Assessment of NMR Probes for the Experimental Description of Protein Folding Pathways with High-Pressure NMR

  Van Deuren V, Yang YS, deGuillen K, Dubois C, Royer CA, Roumestand C, Barthe P, Biology (Basel), 2021

• The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop

  Labbe JC, Vigneron S, Mechali F, Robert P, Roque S, Genoud C, Goguet-Rubio P, Barthe P, Labesse G, Cohen-Gonsaud M, Castro A, Lorca T, Nat Commun, 2021

• Pressure and Chemical Unfolding of an alpha-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1

  Dubois C, Planelles-Herrero VJ, Tillatte-Tripodi C, Delbecq S, Mammri L, Sirkia EM, Ropars V, Roumestand C, Barthe P, Int J Mol Sci, 2021

2020

• Combining High-Pressure Perturbation with NMR Spectroscopy for a Structural and Dynamical Characterization of Protein Folding Pathways

  Dubois C, Herrada I, Barthe P, Roumestand C, Molecules, 2020

2019

• Structural genomics applied to the rust fungus Melampsora larici-populina reveals two candidate effector proteins adopting cystine knot and NTF2-like protein folds

  deGuillen K, Lorrain C, Tsan P, Barthe P, Petre B, Saveleva N, Rouhier N, Duplessis S, Padilla A, Hecker A, Sci Rep, 2019

• Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112

  Alqaseer K, Turapov O, Barthe P, Jagatia H, De Visch A, Roumestand C, Wegrzyn M, Bartek IL, Voskuil MI, O'Hare HM, Ajuh P, Bottrill AR, Witney AA, Cohen-Gonsaud M, Waddell SJ, Mukamolova GV, Mol Microbiol, 2019

• Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression

  Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernado P, Structure, 2019

• Folding of the Ig-Like Domain of the Dengue Virus Envelope Protein Analyzed by High-Hydrostatic-Pressure NMR at a Residue-Level Resolution

  Saotome T, Doret M, Kulkarni M, Yang YS, Barthe P, Kuroda Y, Roumestand C, Biomolecules, 2019

• Structural basis for chemically-induced homodimerization of a single domain antibody

  Lesne J, Chang HJ, De Visch A, Paloni M, Barthe P, Guichou JF, Mayonove P, Barducci A, Labesse G, Bonnet J, Cohen-Gonsaud M, Sci Rep, 2019

2018

• Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis

  Turapov O, Forti F, Kadhim B, Ghisotti D, Sassine J, Straatman-Iwanowska A, Bottrill AR, Moynihan PJ, Wallis R, Barthe P, Cohen-Gonsaud M, Ajuh P, Vollmer W, Mukamolova GV, Cell Rep, 2018

• A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts

  Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jager D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U, J Nucl Med, 2018

• Monitoring Unfolding of Titin I27 Single and Bi Domain with High-Pressure NMR Spectroscopy

  Herrada I, Barthe P, Vanheusden M, DeGuillen K, Mammri L, Delbecq S, Rico F, Roumestand C, Biophys J, 2018

2016

• Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization

  Barthe P, Veyron-Churlet R, de Visch A, Gilleron M, Saliou JM, Tomavo S, Nigou J, Brodin P, Cohen-Gonsaud M, Structure, 2016

2015

• Evolutionarily Conserved Pattern of Interactions in a Protein Revealed by Local Thermal Expansion Properties

  Dellarole M, Caro JA, Roche J, Fossat M, Barthe P, Garcia-Moreno E B, Royer CA, Roumestand C, J Am Chem Soc, 2015

• The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth

  Turapov O, Loraine J, Jenkins CH, Barthe P, McFeely D, Forti F, Ghisotti D, Hesek D, Lee M, Bottrill AR, Vollmer W, Mobashery S, Cohen-Gonsaud M, Mukamolova GV, Open Biol, 2015

2013

• 1H, 1aN and 13C Backbone resonance assignments of a conformational mutant of the adhesion protein a-Bd37 from Babesia divergens

  Barthe P, Murciano B, Schetters T, Gorenflot A, Delbecq S, Roumestand C, Biomol NMR Assign, 2013

• Equivalence between Euler angle conventions for the description of tensorial interactions in liquid NMR: application to different software programs

  Dosset P, Barthe P, Cohen-Gonsaud M, Roumestand C, Demene H, J Biomol NMR, 2013

• A disulfide-constrained miniprotein with striking tumor-binding specificity developed by ribosome display

  Zoller F, Markert A, Barthe P, Hebling U, Altmann A, Lindner T, Mier W, Haberkorn U, Angew Chem Int Ed Engl, 2013

2012

• Cavities determine the pressure unfolding of proteins

  Roche J, Caro JA, Norberto DR, Barthe P, Roumestand C, Schlessman JL, Garcia AE, Garcia-Moreno BE, Royer CA, Proc Natl Acad Sci U S A, 2012

• Combination of phage display and molecular grafting generates highly specific tumor-targeting miniproteins.

  Zoller F, Markert A, Barthe P, Zhao W, Weichert W, Askoxylakis V, Altmann A, Mier W, Haberkorn U, Angew. Chem. Int. Ed. Engl., 2012

2011

• Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase

  Roumestand C, Leiba J, Galophe N, Margeat E, Padilla A, Bessin Y, Barthe P, Molle V, Cohen-Gonsaud M, Structure, 2011

2010

• The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation

  Barthe P, Mukamolova GV, Roumestand C, Cohen-Gonsaud M, Structure, 2010

2009

• Dynamic and structural characterization of a bacterial FHA protein reveals a new autoinhibition mechanism

  Barthe P, Roumestand C, Canova MJ, Kremer L, Hurard C, Molle V, Cohen-Gonsaud M, Structure, 2009

• Structural studies of the complex between Akt-in and the Akt2-PH domain suggest that the peptide acts as an allosteric inhibitor of the Akt kinase

  Ropars V, Barthe P, Wang CS, Chen W, Tzou DL, Descours A, Martin L, Noguchi M, Roumestand C, Open Spect J, 2009

• The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation

  Cohen-Gonsaud M, Barthe P, Canova MJ, Stagier-Simon C, Kremer L, Roumestand C, Molle V, J Biol Chem, 2009

2008

• Analysis of the C12A-p8MTCP1 protein internal motions using Fast Density Mapping at multiple magnetic fields

  Ropars V, Roche J, Barthe P, Roumestand C, C.R. Chimie, 2008

2007

• Structural analysis of cassiicolin, a host-selective protein toxin from Corynespora cassiicola

  Barthe P, Pujade-Renaud V, Breton F, Gargani D, Thai R, Roumestand C, de Lamotte F, J Mol Biol, 2007

• Unraveling protein dynamics through fast spectral density mapping

  Ropars V, Bouguet-Bonnet S, Auguin D, Barthe P, Canet D, Roumestand C, J Biomol NMR, 2007

2006

• DYNAMOF: a program for the dynamics analysis of relaxation data obtained at multiple magnetic fields.

  Barthe P, Ropars V, Roumestand C, C. R. Chimie, 2006

• Structural basis for the Akt (PKB) kinase inhibition by the peptide Akt-in: an NMR study.

  Ropars V, Guichou J-F, Auguin D, Barthe P, Noguchi M, Roumestand C, C. R. Chimie, 2006

2005

• The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes

  Cohen-Gonsaud M, Barthe P, Bagneris C, Henderson B, Ward J, Roumestand C, Keep NH, Nat Struct Mol Biol, 2005

• Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth

  Huang CC, Stricher F, Martin L, Decker JM, Majeed S, Barthe P, Hendrickson WA, Robinson J, Roumestand C, Sodroski J, Wyatt R, Shaw GM, Vita C, Kwong PD, Structure, 2005

• A high-throughput fluorescence polarization assay specific to the CD4 binding site of HIV-1 glycoproteins based on a fluorescein-labelled CD4 mimic

  Stricher F, Martin L, Barthe P, Pogenberg V, Mechulam A, Menez A, Roumestand C, Veas F, Royer C, Vita C, Biochem J, 2005

2004

• Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates

  Auguin D, Barthe P, Auge-Senegas MT, Stern MH, Noguchi M, Roumestand C, J Biomol NMR, 2004

• Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins

  Auguin D, Barthe P, Royer C, Stern MH, Noguchi M, Arold ST, Roumestand C, J Biol Chem, 2004

• Design of an amphipatic a-helical hairpin peptide

  Barthe P, Cohen-Gonsaud M, Aldrian-Herrada G, Chavanieu A, Labesse G, Roumestand C, Comptes Rendus Chimie, 2004

• (1)H, (15)N, and (13)C chemical shift assignments of the resuscitation promoting factor domain of Rv1009 from Mycobacterium tuberculosis

  Cohen-Gonsaud M, Barthe P, Pommier F, Harris R, Driscoll PC, Keep NH, Roumestand C, J Biomol NMR, 2004

2003

• Synthesis and NMR structure of p41icf, a potent inhibitor of human cathepsin L

  Chiva C, Barthe P, Codina A, Gairi M, Molina F, Granier C, Pugniere M, Inui T, Nishio H, Nishiuchi Y, Kimura T, Sakakibara S, Albericio F, Giralt E, J. Am. Chem. Soc., 2003

• Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes

  Martin L, Stricher F, Misse D, Sironi F, Pugniere M, Barthe P, Prado-Gotor R, Freulon I, Magne X, Roumestand C, Menez A, Lusso P, Veas F, Vita C, Nat Biotechnol, 2003

• 1H, (15)N and (13)C chemical shift assignments of the Pleckstrin Homology domain of the Human Protein Kinase B (Pkb/Akt)

  Auguin D, Barthe P, Auge-Senegas MT, Hoh F, Noguchi M, Roumestand C, J. Biomol. NMR, 2003

2002

• Helix motion in protein C12A-p8(MTCP1): comparison of molecular dynamics simulations and multifield NMR relaxation data

  Barthe P, Roumestand C, Demene H, Chiche L, J. Comput. Chem., 2002

• Structure refinement of flexible proteins using dipolar couplings: application to the protein p8MTCP1

  Demene H, Ducat T, Barthe P, Delsuc MA, Roumestand C, J. Biomol. NMR., 2002

2001

• A comprehensive analysis of multifield 15N relaxation parameters in proteins: determination of 15N chemical shift anisotropies

  Canet D, Barthe P, Mutzenhardt P, Roumestand C, J. Am. Chem. Soc., 2001

• FIRE: predicting the spatial proximity of protein residues from 3D NOESY-HSQC

  Malliavin T, Barthe P, Delsuc MA, Theor. Chem. Acc., 2001

• Characterization of the folding and unfolding reactions of a small beta-barrel protein of novel topology, the MTCP1 oncogene product P13

  Roumestand C, Boyer M, Guignard L, Barthe P, Royer CA, J. Mol. Biol., 2001

2000

• Synthesis and NMR solution structure of an alpha-helical hairpin stapled with two disulfide bridges

  Barthe P, Rochette S, Vita C, Roumestand C, Protein Sci., 2000

• Engineering novel bioactive mini-proteins on natural scaffolds

  Martin L, Barthe P, Combes O, Roumestand C, Vita C, Tetrahedron, 2000

1999

• Refined solution structure and backbone dynamics of 15N-labeled C12A-p8MTCP1 studied by NMR relaxation

  Barthe P, Chiche L, Declerck N, Delsuc MA, Lefevre JF, Malliavin T, Mispelter J, Stern MH, Lhoste JM, Roumestand C, J. Biomol. NMR., 1999

• Backbone dynamics study of C12A-p8MTCP1 using the linear correlation approach at two magnetic field strengths. Effect of protein aggregation.

  Barthe P, Declerck N, Delsuc MA, Lefevre JF, Roumestand C, J. Chim. Phys., 1999

• Two well-defined motifs in the cAMP-dependent protein kinase inhibitor (PKIalpha) correlate with inhibitory and nuclear export function

  Hauer JA, Barthe P, Taylor SS, Parello J, Padilla A, Protein Sci., 1999

1998

• The preliminary solution structure of human p8MTCP1, a protein encoded by the putative MTCP1 oncogene

  Barthe P, Guignard L, Yang YS, Chiche L, Strub MP, Hoh F, Stern MH, Roumestand C, J. Chim. Phys., 1998

1997

• Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif

  Barthe P, Yang YS, Chiche L, Hoh F, Strub MP, Guignard L, Soulier J, Stern MH, van Tilbeurgh H, Lhoste JM, Roumestand C, J. Mol. Biol., 1997