Liste des publications

2025

• Binding-Site Switch for Protein Kinase CK2 Inhibitors

  Grenier D, Gelin M, Yang Y, Mularoni A, Guichou JF, Delcros JG, Krimm I, ChemMedChem, 2025

• Binding-site switch of Protein Kinase CK2 inhibitors

  Krimm I, Grenier D, Gelin M, Yang Cbs Cnrs Fr Y, Mularoni A, Guichou JF, Delcros JG, ChemMedChem, 2025

2024

• Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric alphaD pocket

  Bancet A, Frem R, Jeanneret F, Mularoni A, Bazelle P, Roelants C, Delcros JG, Guichou JF, Pillet C, Coste I, Renno T, Battail C, Cochet C, Lomberget T, Filhol O, Krimm I, iScience, 2024

2023

• Linkers in fragment-based drug design: an overview of the literature

  Grenier D, Audebert S, Preto J, Guichou JF, Krimm I, Expert Opin Drug Discov, 2023

2020

• Fragment Linking Strategies for Structure-Based Drug Design

  Bancet A, Raingeval C, Lomberget T, Le Borgne M, Guichou JF, Krimm I, J Med Chem, 2020

2016

• Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

  Ahmed-Belkacem A, Colliandre L, Ahnou N, Nevers Q, Gelin M, Bessin Y, Brillet R, Cala O, Douguet D, Bourguet W, Krimm I, Pawlotsky JM, Guichou JF, Nat Commun, 2016

2015

• Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach

  Marton Z, Guillon R, Krimm I, PreetiRahimova R, Egron D, Jordheim LP, Aghajari N, Dumontet C, Perigaud C, Lionne C, Peyrottes S, Chaloin L, J Med Chem, 2015

2014

• Comparing Binding Modes of Analogous Fragments Using NMR in Fragment-Based Drug Design: Application to PRDX5

  Aguirre C, Brink TT, Guichou JF, Cala O, Krimm I, PLoS ONE, 2014

• Protein-ligand structure guided by backbone and side-chain proton chemical shift perturbations

  Aguirre C, Ten Brink T, Cala O, Guichou JF, Krimm I, J Biomol NMR, 2014

2005

• Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism

  Echalier A, Trivelli X, Corbier C, Rouhier N, Walker O, Tsan P, Jacquot JP, Aubry A, Krimm I, Lancelin JM, Biochemistry, 2005