Liste des publications

2025

• Cryo-EM structure and regulation of human NAD kinase

  Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G, Sci Adv, 2025

• APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus

  Kaplan E, Chaloin L, Guichou JF, Berrou K, Rahimova R, Labesse G, Lionne C, ChemMedChem, 2025

2024

• Increases in cyclin A/Cdk activity and in PP2A-B55 inhibition by FAM122A are key mitosis-inducing events

  Lacroix B, Vigneron S, Labbe JC, Pintard L, Lionne C, Labesse G, Castro A, Lorca T, EMBO J, 2024

2023

• wTSA-CRAFT: an open-access web server for rapid analysis of thermal shift assay experiments

  Reys V, Kowalewski J, Gelin M, Lionne C, Bioinform Adv, 2023

• Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization

  Morichaud Z, Trapani S, Vishwakarma RK, Chaloin L, Lionne C, Lai-Kee-Him J, Bron P, Brodolin K, Nat Commun, 2023

2022

• Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria

  Clement DA, Gelin M, Leseigneur C, Huteau V, Mondange L, Pons JL, Dussurget O, Lionne C, Labesse G, Pochet S, Eur J Med Chem, 2022

• Structure-based design, synthesis and biological evaluation of a NAD+analogue targeting Pseudomonas aeruginosa NAD kinase

  Rahimova R, Nogaret P, Huteau V, Gelin M, Clement DA, Labesse G, Pochet S, Blanc-Potard AB, Lionne C, FEBS J, 2022

• Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation

  Mary C, Soflaee MH, Kesavan R, Gelin M, Brown H, Zacharias G, Mathews TP, Lemoff A, Lionne C, Labesse G, Hoxhaj G, Mol Cell, 2022

2020

• New Chemical Probe Targeting Bacterial NAD Kinase

  Clement DA, Leseigneur C, Gelin M, Coelho D, Huteau V, Lionne C, Labesse G, Dussurget O, Pochet S, Molecules, 2020

2019

• Increase in muscle power is associated with myofibrillar ATPase adaptations during resistance training

  Philippe AG, Lionne C, Sanchez AMJ, Pagano AF, Candau R, Exp Physiol, 2019

2018

• An engineered device for indoleacetic acid production under quorum sensing signals enables Cupriavidus pinatubonensis JMP134 to stimulate plant growth

  Zuniga A, De la Fuente F, Federici F, Lionne C, Bonnet J, de Lorenzo V, Gonzalez B, ACS Synth Biol, 2018

• Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface

  Rahimova R, Fontanel S, Lionne C, Jordheim LP, Peyrottes S, Chaloin L, PLoS Comput Biol, 2018

2017

• Are there two different binding sites for ATP on the myosin head, or only one that switches between two conformers?

  Tesi C, Barman T, Lionne C, J Muscle Res Cell Motil, 2017

• Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases

  Leban N, Kaplan E, Chaloin L, Godreuil S, Lionne C, Biochim Biophys Acta, 2017

2016

• Intracellular Metabolism of Nucleoside/Nucleotide Analogues: a Bottleneck to Reach Active Drugs on HIV Reverse Transcriptase

  Varga A, Lionne C, Roy B, Curr Drug Metab, 2016

• Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation

  Nguyen Van T, Hospital A, Lionne C, Jordheim LP, Dumontet C, Perigaud C, Chaloin L, Peyrottes S, Beilstein J Org Chem, 2016

• Aminoglycoside binding and catalysis specificity of aminoglycoside 2a-phosphotransferase IVa: A thermodynamic, structural and kinetic study

  Kaplan E, Guichou JF, Chaloin L, Kunzelmann S, Leban N, Serpersu EH, Lionne C, Biochim Biophys Acta, 2016

2015

• Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach

  Marton Z, Guillon R, Krimm I, PreetiRahimova R, Egron D, Jordheim LP, Aghajari N, Dumontet C, Perigaud C, Lionne C, Peyrottes S, Chaloin L, J Med Chem, 2015

• Chronic clenbuterol treatment compromises force production without directly altering skeletal muscle contractile machinery

  Py G, Ramonatxo C, Sirvent P, Sanchez AM, Philippe AG, Douillard A, Galbes O, Lionne C, Bonnieu A, Chopard A, Cazorla O, Lacampagne A, Candau RB, J Physiol (Lond), 2015

2014

• Structure-activity relationships of beta-hydroxyphosphonate nucleoside analogues as cytosolic 5'-nucleotidase II potential inhibitors: synthesis, in vitro evaluation and molecular modeling studies

  Meurillon M, Marton Z, Hospital A, Jordheim LP, Bejaud J, Lionne C, Dumontet C, Perigaud C, Chaloin L, Peyrottes S, Eur J Med Chem, 2014

• Aedesin: Structure and Antimicrobial Activity against Multidrug Resistant Bacterial Strains

  Godreuil S, Leban N, Padilla A, Hamel R, Luplertlop N, Chauffour A, Vittecoq M, Hoh F, Thomas F, Sougakoff W, Lionne C, Yssel H, Misse D, PLoS ONE, 2014

2013

• Selectivity of kinases on the activation of tenofovir, an anti-HIV agent

  Varga A, Graczer E, Chaloin L, Liliom K, Zavodszky P, Lionne C, Vas M, Eur J Pharm Sci, 2013

• Montpellier Infectious Diseases (MID), 2nd annual meeting (2012)

  Bastien P, Braun-Breton C, Chazal N, Devaux C, Foulongne V, Frank M, Hernandez JF, Kremer L, Lebrun M, Le Moing V, Leonetti JP, Lionne C, Peyrottes S, Infect Genet Evol, 2013

• Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening

  Jordheim LP, Marton Z, Rhimi M, Cros-Perrial E, Lionne C, Peyrottes S, Dumontet C, Aghajari N, Chaloin L, Biochem Pharmacol, 2013

2012

• Transient kinetics of aminoglycoside phosphotransferase(3')-IIIa reveals a potential drug target in the antibiotic resistance mechanism

  Lallemand P, Leban N, Kunzelmann S, Chaloin L, Serpersu EH, Webb MR, Barman T, Lionne C, FEBS Lett, 2012

2011

• Nucleotide promiscuity of 3-phosphoglycerate kinase is in focus: implications for the design of better anti-HIV analogues

  Varga A, Chaloin L, Sagi G, Sendula R, Graczer E, Liliom K, Zavodszky P, Lionne C, Vas M, Mol Biosyst, 2011

• Ligand chirality effects on the dynamics of human 3-phosphoglycerate kinase: comparison between D- and L-nucleotides

  Palmai Z, Perahia D, Lionne C, Fidy J, Balog E, Chaloin L, Arch Biochem Biophys, 2011

• Interaction of human 3-phosphoglycerate kinase with its two substrates: is substrate antagonism a kinetic advantage?

  Lallemand P, Chaloin L, Roy B, Barman T, Bowler MW, Lionne C, J Mol Biol, 2011

• Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues

  Gallier F, Lallemand P, Meurillon M, Jordheim LP, Dumontet C, Perigaud C, Lionne C, Peyrottes S, Chaloin L, PLoS Comput Biol, 2011

2010

• Electrostatic repulsion between HIV-1 capsid proteins modulates hexamer plasticity and in vitro assembly

  Brun S, Chaloin L, Gay B, Bernard E, Devaux C, Lionne C, Chazal N, Briant L, Proteins, 2010

2009

• Substrate binding modifies the hinge bending characteristics of human 3-phosphoglycerate kinase: a molecular dynamics study

  Palmai Z, Chaloin L, Lionne C, Fidy J, Perahia D, Balog E, Proteins, 2009

• Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin

  Albet-Torres N, Bloemink MJ, Barman T, Candau R, Frolander K, Geeves MA, Golker K, Herrmann C, Lionne C, Piperio C, Schmitz S, Veigel C, Mansson A, J Biol Chem, 2009

• Direct kinetic evidence that lysine 215 is involved in the phospho-transfer step of human 3-phosphoglycerate kinase

  Varga A, Lionne C, Lallemand P, Szabo J, Adamek N, Valentin C, Vas M, Barman T, Chaloin L, Biochemistry, 2009

2008

• Interaction of human 3-phosphoglycerate kinase with L-ADP, the mirror image of D-ADP

  Varga A, Szabo J, Flachner B, Roy B, Konarev P, Svergun D, Zavodszky P, Perigaud C, Barman T, Lionne C, Vas M, Biochem Biophys Res Commun, 2008

• Paradoxical effects of endurance training and chronic hypoxia on myofibrillar ATPase activity

  Roels B, Reggiani C, Reboul C, Lionne C, Iorga B, Obert P, Tanguy S, Gibault A, Jougla A, Travers F, Millet GP, Candau R, Am J Physiol Regul Integr Comp Physiol, 2008

• Differences in the transient kinetics of the binding of D-ADP and its mirror image L-ADP to human 3-phosphoglycerate kinase revealed by the presence of 3-phosphoglycerate

  Gondeau C, Chaloin L, Varga A, Roy B, Lallemand P, Perigaud C, Barman T, Vas M, Lionne C, Biochemistry, 2008

• Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase

  Gondeau C, Chaloin L, Lallemand P, Roy B, Perigaud C, Barman T, Varga A, Vas M, Lionne C, Arold ST, Nucleic Acids Res, 2008

2007

• p66 Trp24 and Phe61 are essential for accurate association of HIV-1 reverse transcriptase with primer/template

  Agopian A, Depollier J, Lionne C, Divita G, J Mol Biol, 2007

2006

• The identification of chemical intermediates in enzyme catalysis by the rapid quench-flow technique

  Barman TE, Bellamy SR, Gutfreund H, Halford SE, Lionne C, Cell Mol Life Sci, 2006

2005

• Perturbation of yeast 3-phosphoglycerate kinase reaction mixtures with ADP: transient kinetics of formation of ATP from bound 1,3-bisphosphoglycerate

  Geerlof A, Travers F, Barman T, Lionne C, Biochemistry, 2005

2004

• Does phosphate release limit the ATPases of soleus myofibrils? Evidence that (A)M. ADP.Pi states predominate on the cross-bridge cycle

  Iorga B, Candau R, Travers F, Barman T, Lionne C, J Muscle Res Cell Motil, 2004

2003

• Why choose myofibrils to study muscle myosin ATPase?

  Lionne C, Iorga B, Candau R, Travers F, J Muscle Res Cell Motil, 2003

• At physiological temperatures the ATPase rates of shortening soleus and psoas myofibrils are similar

  Candau R, Iorga B, Travers F, Barman T, Lionne C, Biophys J, 2003

2002

• Evidence that phosphate release is the rate-limiting step on the overall ATPase of psoas myofibrils prevented from shortening by chemical cross-linking

  Lionne C, Iorga B, Candau R, Piroddi N, Webb MR, Belus A, Travers F, Barman T, Biochemistry, 2002

2001

• Localization of myosin Va is dependent on the cytoskeletal organization in the cell

  Lionne C, Buss F, Hodge T, Ihrke G, Kendrick-Jones J, Biochem Cell Biol, 2001

2000

• Kinetics of the initial steps of rabbit psoas myofibrillar ATPases studied by tryptophan and pyrene fluorescence stopped-flow and rapid flow-quench. Evidence that cross-bridge detachment is slower than ATP binding

  Stehle R, Lionne C, Travers F, Barman T, Biochemistry, 2000

1999

• Cryoenzymic studies on an organized system: myofibrillar ATPases and shortening

  Lionne C, Stehle R, Travers F, Barman T, Biochemistry, 1999

1998

• The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation

  Buss F, Kendrick-Jones J, Lionne C, Knight AE, Cote GP, Paul Luzio J, J Cell Biol, 1998

• ATPase and shortening rates in frog fast skeletal myofibrils by time-resolved measurements of protein-bound and free Pi

  Barman T, Brune M, Lionne C, Piroddi N, Poggesi C, Stehle R, Tesi C, Travers F, Webb MR, Biophys J, 1998

• Probing the coupling of Ca2+ and rigor activation of rabbit psoas myofibrillar ATPase with ethylene glycol

  Stehle R, Lionne C, Travers F, Barman T, J Muscle Res Cell Motil, 1998

1996

• Mechanochemical coupling in muscle: attempts to measure simultaneously shortening and ATPase rates in myofibrils

  Lionne C, Travers F, Barman T, Biophys J, 1996

1995

• Time resolved measurements show that phosphate release is the rate limiting step on myofibrillar ATPases

  Lionne C, Brune M, Webb MR, Travers F, Barman T, FEBS Lett, 1995

• The myofibril as a model for muscle fiber ATPase

  Lionne C, Herrmann C, Travers F, Barman T, Biophys J, 1995

1994

• Interdependence of phospholipid specificity and calcium binding in annexin I as shown by site-directed mutagenesis

  Trave G, Quignard JF, Lionne C, Sri Widada J, Liautard JP, Biochim Biophys Acta, 1994

• Correlation of ActoS1, myofibrillar, and muscle fiber ATPases

  Herrmann C, Lionne C, Travers F, Barman T, Biochemistry, 1994

• Site-directed mutagenesis of a calcium binding site modifies specifically the different biochemical properties of annexin I

  Trave G, Cregut D, Lionne C, Quignard JF, Chiche L, Sri Widada J, Liautard JP, Protein Eng, 1994