Pierre Germain
Les Récepteurs Nucléaires, Intégrateurs de Signaux Endogènes et Environnementaux
04 67 41 77 02
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Liste des publications
2023
2022
Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex
Gruszczyk J, Grandvuillemin L, Lai-Kee-Him J, Paloni M, Savva CG, Germain P, Grimaldi M, Boulahtouf A, Kwong HS, Bous J, Ancelin A, Bechara C, Barducci A, Balaguer P, Bourguet W, Nat Commun, 2022
Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids
le Maire A, Rey M, Vivat V, Guee L, Blanc P, Malosse C, Chamot-Rooke J, Germain P, Bourguet W, J Mol Endocrinol, 2022
Ligands and DNA in the allosteric control of retinoid receptors function
Germain P, Rochel N, Bourguet W, Essays Biochem, 2022
2021
2020
2019
Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
le Maire A, Teyssier C, Balaguer P, Bourguet W, Germain P, Cells, 2019
Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernado P, Structure, 2019
2018
Pathological interactions between mutant thyroid hormone receptors and corepressors and their modulation by a thyroid hormone analogue with therapeutic potential
Harrus D, Demene H, Vasquez EF, Boulahtouf A, Germain P, Figueira AC, Privalsky ML, Bourguet W, le Maire A, Thyroid, 2018
The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation
Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Kumar Nadendla E, Bertucci PY, Germain P, Tomancak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M, Sci Adv, 2018
2015
2013
2011
2010
2009
Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists
Alvarez S, Alvarez R, Khanwalkar H, Germain P, Lemaire G, Rodriguez-Barrios F, Gronemeyer H, de Lera AR, Bioorg Med Chem, 2009
Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists
Germain P, Gaudon C, Pogenberg V, Sanglier S, Van Dorsselaer A, Royer CA, Lazar MA, Bourguet W, Gronemeyer H, Chem Biol, 2009
Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-y l)phenyl]acrylic acids and their 4-alkoxy isomers
Perez Santin E, Germain P, Quillard F, Khanwalkar H, Rodriguez-Barrios F, Gronemeyer H, de Lera AR, Bourguet W, J Med Chem, 2009
Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
Rochette-Egly C, Germain P, Nucl Recept Signal, 2009
Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus
Tocchini-Valentini GD, Rochel N, Escriva H, Germain P, Peluso-Iltis C, Paris M, Sanglier-Cianferani S, Van Dorsselaer A, Moras D, Laudet V, J Biol Chem, 2009