Gilles Labesse
ABCIS: Atelier de Bio & Chimie Informatique Structurale
04 67 41 77 12
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Liste des publications
2025
Cryo-EM structure and regulation of human NAD kinase
Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G, Sci Adv, 2025
APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus
Kaplan E, Chaloin L, Guichou JF, Berrou K, Rahimova R, Labesse G, Lionne C, ChemMedChem, 2025
2024
@TOME 3.0: Interfacing Protein Structure Modeling and Ligand Docking
Pons JL, Reys V, Grand F, Moreau V, Gracy J, Exner TE, Labesse G, J Mol Biol, 2024
Detection and Analysis of Short Linear Motif-Based Protein-Protein Interactions with SLiMAn2 Web Server
Mezghrani A, Simon J, Reys V, Labesse G, Methods Mol Biol, 2024
SLiMAn 2.0: meaningful navigation through peptide-protein interaction networks
Reys V, Pons JL, Labesse G, Nucleic Acids Res, 2024
Increases in cyclin A/Cdk activity and in PP2A-B55 inhibition by FAM122A are key mitosis-inducing events
Lacroix B, Vigneron S, Labbe JC, Pintard L, Lionne C, Labesse G, Castro A, Lorca T, EMBO J, 2024
2023
2022
Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria
Clement DA, Gelin M, Leseigneur C, Huteau V, Mondange L, Pons JL, Dussurget O, Lionne C, Labesse G, Pochet S, Eur J Med Chem, 2022
Structure-based design, synthesis and biological evaluation of a NAD+analogue targeting Pseudomonas aeruginosa NAD kinase
Rahimova R, Nogaret P, Huteau V, Gelin M, Clement DA, Labesse G, Pochet S, Blanc-Potard AB, Lionne C, FEBS J, 2022
Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation
Mary C, Soflaee MH, Kesavan R, Gelin M, Brown H, Zacharias G, Mathews TP, Lemoff A, Lionne C, Labesse G, Hoxhaj G, Mol Cell, 2022
SLiMAn: An Integrative Web Server for Exploring Short Linear Motif-Mediated Interactions in Interactomes
Reys V, Labesse G, J Proteome Res, 2022
A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti-Toxoplasmaand Anti-PlasmodiumActivities Controls Acute and Chronic ToxoplasmaInfection in Mice
Jublot D, Cavailles P, Kamche S, Francisco D, Fontinha D, Prudencio M, Guichou JF, Labesse G, Sereno D, Loeuillet C, Int J Mol Sci, 2022
Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target
Walter P, Mechaly A, Bous J, Haouz A, England P, Lai-Kee-Him J, Ancelin A, Hoos S, Baron B, Trapani S, Bron P, Labesse G, Munier-Lehmann H, FEBS J, 2022
Structural evolution of the ancient enzyme, dissimilatory sulfite reductase
Colman DR, Labesse G, Swapna GVT, Stefanakis J, Montelione GT, Boyd ES, Royer CA, Proteins, 2022
2021
Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding
Schneider M, Delfosse V, Gelin M, Grimaldi M, Granell M, Heriaud L, Pons JL, Cohen Gonsaud M, Balaguer P, Bourguet W, Labesse G, J Med Chem, 2021
CRB1-Related Retinal Dystrophies in a Cohort of 50 Patients: A Reappraisal in the Light of Specific Muller Cell and Photoreceptor CRB1Isoforms
Mairot K, Smirnov V, Bocquet B, Labesse G, Arndt C, Defoort-Dhellemmes S, Zanlonghi X, Hamroun D, Denis D, Picot MC, David T, Grunewald O, Pegart M, Huguet H, Roux AF, Kalatzis V, Dhaenens CM, Meunier I, Int J Mol Sci, 2021
Retinitis Punctata Albescens and RLBP1-Allied Phenotypes: Phenotype-Genotype Correlation and Natural History in the Aim of Gene Therapy
Bocquet B, El Alami Trebki H, Roux AF, Labesse G, Brabet P, Arndt C, Zanlonghi X, Defoort-Dhellemmes S, Hamroun D, Boulicot-Seguin C, Lequeux L, Picot MC, Huguet H, Audo I, Dhaenens CM, Kalatzis V, Meunier I, Ophthalmol Sci, 2021
Proteo3Dnet: a web server for the integration of structural information with interactomics data
Postic G, Andreani J, Marcoux J, Reys V, Guerois R, Rey J, Mouton-Barbosa E, Vandenbrouck Y, Cianferani S, Burlet-Schiltz O, Labesse G, Tuffery P, Nucleic Acids Res, 2021
Exploring the conformational space of a receptor for drug design: An ERalpha case study
Schneider M, Pons JL, Labesse G, J Mol Graph Model, 2021
The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
Labbe JC, Vigneron S, Mechali F, Robert P, Roque S, Genoud C, Goguet-Rubio P, Barthe P, Labesse G, Cohen-Gonsaud M, Castro A, Lorca T, Nat Commun, 2021
The Dynamic Ion Motive Force Powering the Bacterial Flagellar Motor
Biquet-Bisquert A, Labesse G, Pedaci F, Nord AL, Front Microbiol, 2021
2020
An oligomeric switch controls the Mrr-induced SOS response in E. coli
Bourges AC, Torres Montaguth OE, Tadesse W, Labesse G, Aertsen A, Royer CA, Declerck N, DNA Repair (Amst), 2020
New Chemical Probe Targeting Bacterial NAD Kinase
Clement DA, Leseigneur C, Gelin M, Coelho D, Huteau V, Lionne C, Labesse G, Dussurget O, Pochet S, Molecules, 2020
[In silico profiling of protein kinases inhibitors]
Reys V, Labesse G, Med Sci (Paris), 2020
Probing Protein Interaction Networks by Combining MS-Based Proteomics and Structural Data Integration
Postic G, Marcoux J, Reys V, Andreani J, Vandenbrouck Y, Bousquet MP, Mouton-Barbosa E, Cianferani S, Burlet-Schiltz O, Guerois R, Labesse G, Tuffery P, J Proteome Res, 2020
From substrate to fragments to inhibitor active in vivo against Staphylococcus aureus
Gelin M, Paoletti J, Nahori MA, Huteau V, Leseigneur C, Jouvion G, Dugue L, Clement D, Pons JL, Assairi L, Pochet S, Labesse G, Dussurget O, ACS Infect Dis, 2020
Towards accurate high-throughput ligand affinity prediction by exploiting structural ensembles, docking metrics and ligand similarity
Schneider M, Pons JL, Bourguet W, Labesse G, Bioinformatics, 2020
2019
In silico predictions of endocrine disruptors properties
Schneider M, Pons JL, Labesse G, Bourguet W, Endocrinology, 2019
Insights into Substrate and Inhibitor Selectivity among Human GLUT Transporters through Comparative Modeling and Molecular Docking
Salgado Ferreira R, Pons JL, Labesse G, ACS Omega, 2019
Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein-Coupled Receptor
Hajj M, De Vita T, Vol C, Renassia C, Bologna JC, Brabet I, Cazade M, Pastore M, Blahos J, Labesse G, Pin JP, Prezeau L, Mol Pharmacol, 2019
A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor
Loeuillet C, Touquet B, Guichou JF, Labesse G, Sereno D, Int J Mol Sci, 2019
Characterization of XPR1/SLC53A1 variants located outside of the SPX domain in patients with primary familial brain calcification
Lopez-Sanchez U, Nicolas G, Richard AC, Maltete D, Charif M, Ayrignac X, Goizet C, Touhami J, Labesse G, Battini JL, Sitbon M, Sci Rep, 2019
Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2A Receptor by a Mini-G Protein
Renault P, Louet M, Marie J, Labesse G, Floquet N, Sci Rep, 2019
First-in-class allosteric inhibitors of bacterial IMPDHs
Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugue L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H, Eur J Med Chem, 2019
Structural basis for chemically-induced homodimerization of a single domain antibody
Lesne J, Chang HJ, De Visch A, Paloni M, Barthe P, Guichou JF, Mayonove P, Barducci A, Labesse G, Bonnet J, Cohen-Gonsaud M, Sci Rep, 2019
SHEDding light on the role of Pragmin pseudo-kinases in cancer
Roche S, Lecointre C, Simon V, Labesse G, Am J Cancer Res, 2019
Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its sequence-structure-function analysis
Fleury C, Gracy J, Gautier MF, Pons JL, Dufayard JF, Labesse G, Ruiz M, de Lamotte F, PeerJ, 2019
2018
Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation
Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S, Structure, 2018
Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity
Loeuillet C, Touquet B, Oury B, Eddaikra N, Pons JL, Guichou JF, Labesse G, Sereno D, Int J Parasitol Drugs Drug Resist, 2018
2017
2016
8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode
Paoletti J, Assairi L, Gelin M, Huteau V, Nahori MA, Dussurget O, Labesse G, Pochet S, Eur J Med Chem, 2016
A new autosomal dominant eye and lung syndrome linked to mutations in TIMP3 gene
Meunier I, Bocquet B, Labesse G, Zeitz C, Defoort-Dhellemmes S, Lacroux A, Mauget-Faysse M, Drumare I, Gamez AS, Mathieu C, Marquette V, Sagot L, Dhaenens CM, Arndt C, Carroll P, Remy-Jardin M, Cohen SY, Sahel JA, Puech B, Audo I, Mrejen S, Hamel CP, Sci Rep, 2016
A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium
Meunier I, Lenaers G, Bocquet B, Baudoin C, Piro-Megy C, Cubizolle A, Quiles M, Jean-Charles A, Cohen SY, Merle H, Gaudric A, Labesse G, Manes G, Pequignot M, Cazevieille C, Dhaenens CM, Fichard A, Ronkina N, Arthur SJ, Gaestel M, Hamel CP, Hum Mol Genet, 2016
2015
Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation
Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H, Acta Crystallogr D Biol Crystallogr, 2015
Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography
Gelin M, Delfosse V, Allemand F, Hoh F, Sallaz-Damaz Y, Pirocchi M, Bourguet W, Ferrer JL, Labesse G, Guichou JF, Acta Crystallogr D Biol Crystallogr, 2015
2014
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: Synthesis, structural studies and cytotoxic activities
Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S, Eur J Med Chem, 2014
Chromatin Insulator Factors Involved in Long-Range DNA Interactions and Their Role in the Folding of the Drosophila Genome
Vogelmann J, Le Gall A, Dejardin S, Allemand F, Gamot A, Labesse G, Cuvier O, Negre N, Cohen-Gonsaud M, Margeat E, Nollmann M, PLoS Genet, 2014
Oleoyl-Coenzyme A Regulates Interaction of Transcriptional Regulator RaaS (Rv1219c) with DNA in Mycobacteria
Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV, J Biol Chem, 2014
Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions
Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV, Antimicrob Agents Chemother, 2014
Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity
Sagnol S, Yang Y, Bessin Y, Allemand F, Hapkova I, Notarnicola C, Guichou JF, Faure S, Labesse G, de Santa Barbara P, Nucleic Acids Res, 2014
Stoichiometry of scaffold complexes in living neurons - DLC2 as a dimerization engine for GKAP
Moutin E, Compan V, Raynaud F, Clerte C, Bouquier N, Labesse G, Ferguson ML, Fagni L, Royer CA, Perroy J, J Cell Sci, 2014
2013
Phosphodeoxyribosyltransferases, designed enzymes for deoxyribonucleotides synthesis
Kaminski PA, Labesse G, J Biol Chem, 2013
Structure of the oncoprotein Rcl bound to three nucleotide analogues
Padilla A, Amiable C, Pochet S, Kaminski PA, Labesse G, Acta Crystallogr D Biol Crystallogr, 2013
Mutations in IMPG1 cause vitelliform macular dystrophies
Manes G, Meunier I, Avila-Fernandez A, Banfi S, Le Meur G, Zanlonghi X, Corton M, Simonelli F, Brabet P, Labesse G, Audo I, Mohand-Said S, Zeitz C, Sahel JA, Weber M, Dollfus H, Dhaenens CM, Allorge D, De Baere E, Koenekoop RK, Kohl S, Cremers FP, Hollyfield JG, Senechal A, Hebrard M, Bocquet B, Ayuso Garcia C, Hamel CP, Am J Hum Genet, 2013
MgATP regulates allostery and fiber formation in IMPDHs
Labesse G, Alexandre T, Vaupre L, Salard-Arnaud I, Him JL, Raynal B, Bron P, Munier-Lehmann H, Structure, 2013
N (6)-Substituted AMPs Inhibit Mammalian Deoxynucleotide N-Hydrolase DNPH1
Amiable C, Pochet S, Padilla A, Labesse G, Kaminski PA, PLoS ONE, 2013
2012
Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes
Delfosse V, Grimaldi M, Pons JL, Boulahtouf A, le Maire A, Cavailles V, Labesse G, Bourguet W, Balaguer P, Proc Natl Acad Sci U S A, 2012
Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound.
Gelin M, Poncet-Montange G, Assairi L, Morellato L, Huteau V, Dugue L, Dussurget O, Pochet S, Labesse G, Structure, 2012
Fragment and conquer: from structure to complexes to function.
Guichou JF, Labesse G, Structure, 2012
The C-terminal domain of the virulence factor MgtC is a divergent ACT domain.
Yang Y, Labesse G, Carrere-Kremer S, Esteves K, Kremer L, Cohen-Gonsaud M, Blanc-Potard AB, J. Bacteriol., 2012
2011
The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation
Gazanion E, Garcia D, Silvestre R, Gerard C, Guichou JF, Labesse G, Seveno M, Cordeiro-Da-Silva A, Ouaissi A, Sereno D, Vergnes B, Mol Microbiol, 2011
Interdomain movements in metabotropic glutamate receptor activation
Huang S, Cao J, Jiang M, Labesse G, Liu J, Pin JP, Rondard P, Proc Natl Acad Sci U S A, 2011
Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation
Labesse G, Benkali K, Salard-Arnaud I, Gilles AM, Munier-Lehmann H, Nucleic Acids Res, 2011
In-plate protein crystallization, in situ ligand soaking and X-ray diffraction
le Maire A, Gelin M, Pochet S, Hoh F, Pirocchi M, Guichou JF, Ferrer JL, Labesse G, Acta Crystallogr D Biol Crystallogr, 2011
Montpellier infectious diseases (MID): 1st annual meeting (2011)
Sitbon M, Biard-Piechaczyk M, Robert V, Briant L, Kohler S, Labesse G, Devaux C, Infect Genet Evol, 2011
Characterization of the mechanisms controlling Greatwall activity
Vigneron S, Gharbi-Ayachi A, Raymond AA, Burgess A, Labbe JC, Labesse G, Monsarrat B, Lorca T, Castro A, Mol Cell Biol, 2011
2009
A 20-amino acid module of protein kinase C{epsilon} involved in translocation and selective targeting at cell-cell contacts
Diouf B, Collazos A, Labesse G, Macari F, Choquet A, Clair P, Gauthier-Rouviere C, Guerineau NC, Jay P, Hollande F, Joubert D, J Biol Chem, 2009
Structural characterization of the mammalian deoxynucleotide N-hydrolase Rcl and its stabilizing interactions with two inhibitors
Yang Y, Padilla A, Zhang C, Labesse G, Kaminski PA, J Mol Biol, 2009
@TOME-2: a new pipeline for comparative modeling of protein-ligand complexes
Pons JL, Labesse G, Nucleic Acids Res, 2009
Inhibition of 7,8-diaminopelargonic acid aminotransferase from Mycobacterium tuberculosis by chiral and achiral anologs of its substrate: biological implications
Mann S, Colliandre L, Labesse G, Ploux O, Biochimie, 2009
ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity
Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF, Structure, 2009
PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity
Monnier C, Dode C, Fabre L, Teixeira L, Labesse G, Pin JP, Hardelin JP, Rondard P, Hum Mol Genet, 2009
2008
A phospho-sugar binding domain homologous to NagB enzymes regulates the activity of the central glycolytic genes repressor
Doan T, Martin L, Zorrilla S, Chaix D, Aymerich S, Labesse G, Declerck N, Proteins, 2008
Comprehensive 3D-modeling of allergenic proteins and amino acid composition of potential conformational IgE epitopes
Oezguen N, Zhou B, Negi SS, Ivanciuc O, Schein CH, Labesse G, Braun W, Mol Immunol, 2008
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning
Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y, Trinquet E, Labesse G, Pin JP, Liu J, Embo J, 2008
2007
Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies
Poncet-Montange G, Ducasse-Cabanot S, Quemard A, Labesse G, Cohen-Gonsaud M, Acta Crystallogr D Biol Crystallogr, 2007
NAD kinases use substrate-assisted catalysis for specific recognition of NAD
Poncet-Montange G, Assairi L, Arold ST, Pochet S, Labesse G, J Biol Chem, 2007
ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii
El Hajj H, Lebrun M, Arold ST, Vial H, Labesse G, Dubremetz JF, PLoS Pathog, 2007
Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors
Binet V, Duthey B, Lecaillon J, Vol C, Quoyer J, Labesse G, Pin JP, Prezeau L, J Biol Chem, 2007
2006
The ROP2 family of Toxoplasma gondii rhoptry proteins: proteomic and genomic characterization and molecular modeling
El Hajj H, Demey E, Poncet J, Lebrun M, Wu B, Galeotti N, Fourmaux MN, Mercereau-Puijalon O, Vial H, Labesse G, Dubremetz JF, Proteomics, 2006
Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1
Ganem C, Miled C, Facca C, Valay JG, Labesse G, Ben Hassine S, Mann C, Faye G, Mol Genet Genomics, 2006
kinDOCK: a tool for comparative docking of protein kinase ligands
Martin L, Catherinot V, Labesse G, Nucleic Acids Res, 2006
The endonuclease domain of bacteriophage terminases belongs to the resolvase/integrase/ribonuclease H superfamily: a bioinformatics analysis validated by a functional study on bacteriophage T5
Ponchon L, Boulanger P, Labesse G, Letellier L, J Biol Chem, 2006
Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors
Rondard P, Liu J, Huang S, Malhaire F, Vol C, Pinault A, Labesse G, Pin JP, J Biol Chem, 2006
The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria
Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM, FEBS Lett, 2006
2005
The nuclear receptor coactivator PGC-1alpha exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1
Bourdoncle A, Labesse G, Margueron R, Castet A, Cavailles V, Royer CA, J Mol Biol, 2005
Structural and functional analysis of the C-terminal STAS (sulfate transporter and anti-sigma antagonist) domain of the Arabidopsis thaliana sulfate transporter SULTR1.2
Rouached H, Berthomieu P, El Kassis E, Cathala N, Catherinot V, Labesse G, Davidian JC, Fourcroy P, J Biol Chem, 2005
Internal point mutations of the capsid modify the serotype of Rice yellow mottle virus
Hebrard E, Pinel-Galzi A, Catherinot V, Labesse G, Brugidou C, Fargette D, J Virol, 2005
LEA3D: A Computer-Aided Ligand Design for Structure-Based Drug Design
Douguet D, Munier-Lehmann H, Labesse G, Pochet S, J Med Chem, 2005
Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change
Cohen-Gonsaud M, Ducasse-Cabanot S, Quemard A, Labesse G, Proteins, 2005
Mutation at the exit gate of the salmonella gyrase a subunit suppresses a defect in the gyrase B subunit
Blanc-Potard AW, Labesse G, Figueroa-Bossi N, Bossi L, J Bacteriol, 2005
2004
Design of an amphipatic a-helical hairpin peptide
Barthe P, Cohen-Gonsaud M, Aldrian-Herrada G, Chavanieu A, Labesse G, Roumestand C, Comptes Rendus Chimie, 2004
Crystallization and preliminary crystallographic studies of MOMP (major outer membrane protein) from Campylobacter jejuni
Bolla JM, Saint N, Labesse G, Pages JM, Dumas C, Acta Crystallogr D Biol Crystallogr, 2004
From molecular modelling to drug design
Cohen-Gonsaud M, Catherinot V, Labesse G, Douguet D, Nucleid Acids and Molecular Biology, Vol 15, Practical Bioinformatics, Ed. by J.M. Bujnicki (2004) Springer-Verlag, 2004
Resuscitation-promoting factors possess a lysozyme-like domain
Cohen-Gonsaud M, Keep NH, Davies AP, Ward J, Henderson B, Labesse G, Trends in Biochemical Sciences, 2004
In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid
Ducasse-Cabanot S, Cohen-Gonsaud M, Marrakchi H, Nguyen M, Zerbib D, Bernadou J, Daffe M, Labesse G, Quemard A, Antimicrob Agents Chemother, 2004
2003
Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast
Ganem C, Devaux F, Torchet C, Jacq C, Quevillon-Cheruel S, Labesse G, Facca C, Faye G, Embo J, 2003
Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain
Hoellerer MK, Noble ME, Labesse G, Campbell ID, Werner JM, Arold ST, Structure (Camb), 2003
Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors
Munier-Lehmann H, Pochet S, Dugue L, Dutruel O, Labesse G, Douget D, Nucleosides Nucleotides Nucleic Acids, 2003
Use of the Protein MABA (FABG1) of MYCOBACTERIUM TUBERCULOSIS for designing and screening antibiotics
Quemard A, Labesse G, Daffe M, Ducasse S, Cohen-Gonsaud M, Douguet D, Marrakchi H, , 2003
2002
From sequence to structure to function: a case study
Douguet D, Bolla J-M, Munier-Lehmann H, Labesse G, Enzyme and Microbial Technology, 2002
Structural and nucleotide-binding properties of YajQ and YnaF, two Escherichia coli proteins of unknown function
Saveanu C, Miron S, Borza T, Craescu CT, Labesse G, Gagyi C, Popescu A, Schaeffer F, Namane A, Laurent-Winter C, Barzu O, Gilles AM, Protein Sci, 2002
Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications
Pochet S, Dugue L, Douguet D, Labesse G, Munier-Lehmann H, Chembiochem, 2002
MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II
Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffe M, Quemard A, Microbiology, 2002
Comparative modelling and immunochemical reactivity of Escherichia coli UMP kinase
Labesse G, Bucurenci N, Douguet D, Sakamoto H, Landais S, Gagyi C, Gilles AM, Barzu O, Biochem Biophys Res Commun, 2002
No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits
Kniazeff J, Galvez T, Labesse G, Pin JP, J Neurosci, 2002
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis
Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A, J Mol Biol, 2002
Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases
Labesse G, Douguet D, Assairi L, Gilles AM, Trends Biochem Sci, 2002
2001
Easier threading through web-based comparisons and cross-validations
Douguet D, Labesse G, Bioinformatics, 2001
Biochemical characterization of the helper component of Cauliflower mosaic virus
Hebrard E, Drucker M, Leclerc D, Hohn T, Uzest M, Froissart R, Strub JM, Sanglier S, van Dorsselaer A, Padilla A, Labesse G, Blanc S, J Virol, 2001
Stepwise modelling optimization from sequence to quaternary structure
Labesse G, Douguet D, Gracy J, Pons J, Chiche L, 4th European Symposium of The Protein Society, 2001
MOMP, a divergent porin from Campylobacter: cloning and primary structural characterization
Labesse G, Garnotel E, Bonnel S, Dumas C, Pages JM, Bolla JM, Biochem Biophys Res Commun, 2001
Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes
Munier-Lehmann H, Chaffotte A, Pochet S, Labesse G, Protein Sci, 2001
2000
MOMP (major outer membrane protein) of Campylobacter jejuni; a versatile pore-forming protein
De E, Jullien M, Labesse G, Pages JM, Molle G, Bolla JM, FEBS Lett, 2000
Molecular cloning and partial characterization of a plant VAP33 homologue with a major sperm protein domain
Laurent F, Labesse G, de Wit P, Biochem Biophys Res Commun, 2000
1999
Sequence analysis identifies a ras-associating (RA)-like domain in the N-termini of band 4.1/JEF domains and in the Grb7/10/14 adapter family
Wojcik J, Girault JA, Labesse G, Chomilier J, Mornon JP, Callebaut I, Biochem Biophys Res Commun, 1999
Structure modelling and site-directed mutagenesis of the rat aromatic L-amino acid pyridoxal 5'-phosphate-dependent decarboxylase: a functional study
Poupon A, Jebai F, Labesse G, Gros F, Thibault J, Mornon JP, Krieger M, Proteins, 1999
The N-termini of FAK and JAKs contain divergent band 4.1 domains
Girault JA, Labesse G, Mornon JP, Callebaut I, Trends Biochem Sci, 1999
Characterization and molecular cloning of an adenosine kinase from Babesia canis rossi
Carret C, Delbecq S, Labesse G, Carcy B, Precigout E, Moubri K, Schetters TP, Gorenflot A, Eur J Biochem, 1999
1998
Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transduction
Girault JA, Labesse G, Mornon JP, Callebaut I, Mol Med, 1998
HAH1 is a copper-binding protein with distinct amino acid residues mediating copper homeostasis and antioxidant defense
Hung IH, Casareno RL, Labesse G, Mathews FS, Gitlin JD, J Biol Chem, 1998
Engineering, expression and biochemical characterization of the hemoglobin domain of a Erwinia chrysanthemi flavohemoprotein
Labesse G, Craescu CT, Mispelter J, Chottard G, Marden MC, Pin S, Forest E, Mornon JP, Boccara M, Eur J Biochem, 1998
Crystallographic and spectroscopic studies of native, aminoquinol, and monovalent cation-bound forms of methylamine dehydrogenase from Methylobacterium extorquens AM1
Labesse G, Ferrari D, Chen ZW, Rossi GL, Kuusk V, McIntire WS, Mathews FS, J Biol Chem, 1998
Incremental threading optimization (TITO) to help alignment and modelling of remote homologues
Labesse G, Mornon J, Bioinformatics, 1998
1997
Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives
Callebaut I, Labesse G, Durand P, Poupon A, Canard L, Chomilier J, Henrissat B, Mornon JP, Cell Mol Life Sci, 1997
P-SEA: a new efficient assignment of secondary structure from C alpha trace of proteins
Labesse G, Colloc'h N, Pothier J, Mornon JP, Comput Appl Biosci, 1997
1996
CMP kinase from Escherichia coli is structurally related to other nucleoside monophosphate kinases
Bucurenci N, Sakamoto H, Briozzo P, Palibroda N, Serina L, Sarfati RS, Labesse G, Briand G, Danchin A, Barzu O, Gilles AM, J Biol Chem, 1996
MulBlast 1.0: a multiple alignment of BLAST output to boost protein sequence similarity analysis
Labesse G, Comput Appl Biosci, 1996
1995
Automat and BLAST: comparison of two protein sequence similarity search programs
Cantalloube H, Labesse G, Chomilier J, Nahum C, Cho YY, Chams V, Achour A, Lachgar A, Mbika JP, Issing W, et al., Comput Appl Biosci, 1995
Flavohaemoglobin HmpX: a new pathogenicity determinant in Erwinia chrysanthemi strain 3937
Favey S, Labesse G, Vouille V, Boccara M, Microbiology, 1995
1994
Structural comparisons lead to the definition of a new superfamily of NAD(P)(H)-accepting oxidoreductases: the single-domain reductases/epimerases/dehydrogenases (the 'RED' family)
Labesse G, Vidal-Cros A, Chomilier J, Gaudry M, Mornon JP, Biochem J, 1994
Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing
Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M, Eur J Biochem, 1994