Liste des publications

2024

• Genome-wide association analysis uncovers rice blast resistance alleles of Ptr and Pia

  Greenwood JR, Lacorte-Apostol V, Kroj T, Padilla J, Telebanco-Yanoria MJ, Glaus AN, Roulin A, Padilla A, Zhou B, Keller B, Krattinger SG, Commun Biol, 2024

• The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited

  Lahfa M, Barthe P, deGuillen K, Cesari S, Raji M, Kroj T, Le Naour-Vernet M, Hoh F, Gladieux P, Roumestand C, Gracy J, Declerck N, Padilla A, PLoS Pathog, 2024

2023

• Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae

  Le Naour-Vernet M, Charriat F, Gracy J, Cros-Arteil S, Ravel S, Veillet F, Meusnier I, Padilla A, Kroj T, Cesari S, Gladieux P, PLoS Pathog, 2023

• Does a Similar 3D Structure Mean a Similar Folding Pathway? The Presence of a C-Terminal alpha-Helical Extension in the 3D Structure of MAX60 Drastically Changes the Folding Pathway Described for Other MAX-Effectors from Magnaporthe oryzae

  Lahfa M, Mouhand A, deGuillen K, Barthe P, Kroj T, Padilla A, Roumestand C, Molecules, 2023

2022

• The activity of the RGA5 sensor NLR from rice requires binding of its integrated HMA domain to effectors but not HMA domain self-interaction

  Xi Y, Chalvon V, Padilla A, Cesari S, Kroj T, Mol Plant Pathol, 2022

• 1H, 13C, 15N backbone and side-chain NMR assignments for three MAX effectors from Magnaporthe oryzae

  Lahfa M, Padilla A, deGuillen K, Pissarra J, Raji M, Cesari S, Kroj T, Gladieux P, Roumestand C, Barthe P, Biomol NMR Assign, 2022

• Combining High-Pressure NMR and Geometrical Sampling to Obtain a Full Topological Description of Protein Folding Landscapes: Application to the Folding of Two MAX Effectors from Magnaporthe oryzae

  Dubois C, Lahfa M, Pissarra J, deGuillen K, Barthe P, Kroj T, Roumestand C, Padilla A, Int J Mol Sci, 2022

• New recognition specificity in a plant immune receptor by molecular engineering of its integrated domain

  Cesari S, Xi Y, Declerck N, Chalvon V, Mammri L, Pugniere M, Henriquet C, deGuillen K, Chochois V, Padilla A, Kroj T, Nat Commun, 2022

2020

• Structural Insights into of the Allosteric Activation of the LicT Antiterminator by PTS-Mediated Phosphorylation

  Yang Y, Padilla A, deGuillen K, Mammri L, Gracy J, Declerck N, Demene H, Structure, 2020

2019

• Structural genomics applied to the rust fungus Melampsora larici-populina reveals two candidate effector proteins adopting cystine knot and NTF2-like protein folds

  deGuillen K, Lorrain C, Tsan P, Barthe P, Petre B, Saveleva N, Rouhier N, Duplessis S, Padilla A, Hecker A, Sci Rep, 2019

2018

• Specific recognition of two MAX effectors by integrated HMA domains in plant immune receptors involves distinct binding surfaces

  Guo L, Cesari S, deGuillen K, Chalvon V, Mammri L, Ma M, Meusnier I, Bonnot F, Padilla A, Peng YL, Liu J, Kroj T, Proc Natl Acad Sci USA, 2018

2017

• Recognition of the Magnaporthe oryzae effector AVR-Pia by the decoy domain of the rice NLR immune receptor RGA5

  Ortiz D, deGuillen K, Cesari S, Chalvon V, Gracy J, Padilla A, Kroj T, Plant Cell, 2017

2015

• Structure Analysis Uncovers a Highly Diverse but Structurally Conserved Effector Family in Phytopathogenic Fungi

  deGuillen K, Ortiz-Vallejo D, Gracy J, Fournier E, Kroj T, Padilla A, PLoS Pathog, 2015

2014

• 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: Synthesis, structural studies and cytotoxic activities

  Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S, Eur J Med Chem, 2014

• Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer

  Birol M, Enchev RI, Padilla A, Stengel F, Aebersold R, Betzi S, Yang Y, Hoh F, Peter M, Dumas C, Echalier A, PLoS ONE, 2014

• Aedesin: Structure and Antimicrobial Activity against Multidrug Resistant Bacterial Strains

  Godreuil S, Leban N, Padilla A, Hamel R, Luplertlop N, Chauffour A, Vittecoq M, Hoh F, Thomas F, Sougakoff W, Lionne C, Yssel H, Misse D, PLoS ONE, 2014

2013

• N (6)-Substituted AMPs Inhibit Mammalian Deoxynucleotide N-Hydrolase DNPH1

  Amiable C, Pochet S, Padilla A, Labesse G, Kaminski PA, PLoS ONE, 2013

• Structure of the oncoprotein Rcl bound to three nucleotide analogues

  Padilla A, Amiable C, Pochet S, Kaminski PA, Labesse G, Acta Crystallogr D Biol Crystallogr, 2013

• Fragment-Based Identification of a Locus in the Sec7 Domain of Arno for the Design of Protein-Protein Interaction Inhibitors

  Rouhana J, Hoh F, Estaran S, Henriquet C, Boublik Y, Kerkour A, Trouillard R, Martinez J, Pugniere M, Padilla A, Chavanieu A, J Med Chem, 2013

• Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A

  Rouhana J, Padilla A, Estaran S, Bakari S, Delbecq S, Boublik Y, Chopineau J, Pugniere M, Chavanieu A, J Biol Chem, 2013

2012

• Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus

  Shu Y, Habchi J, Costanzo S, Padilla A, Brunel J, Gerlier D, Oglesbee M, Longhi S, J Biol Chem, 2012

2011

• Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase

  Roumestand C, Leiba J, Galophe N, Margeat E, Padilla A, Bessin Y, Barthe P, Molle V, Cohen-Gonsaud M, Structure, 2011

2010

• Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108

  Dupouy C, Zhang C, Padilla A, Pochet S, Kaminski PA, J Biol Chem, 2010

2009

• Removing the invariant salt bridge of parvalbumin increases flexibility in the AB-loop structure

  Hoh F, Cave A, Strub MP, Baneres JL, Padilla A, Acta Crystallogr D Biol Crystallogr, 2009

• NMR structure of rALF-Pm3, an anti-lipopolysaccharide factor from shrimp: model of the possible lipid A-binding site

  Yang Y, Boze H, Chemardin P, Padilla A, Moulin G, Tassanakajon A, Pugniere M, Roquet F, Destoumieux-Garzon D, Gueguen Y, Bachere E, Aumelas A, Biopolymers, 2009

• Structural characterization of the mammalian deoxynucleotide N-hydrolase Rcl and its stabilizing interactions with two inhibitors

  Yang Y, Padilla A, Zhang C, Labesse G, Kaminski PA, J Mol Biol, 2009

2007

• Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes

  Viaud J, Zeghouf M, Barelli H, Zeeh JC, Padilla A, Guibert B, Chardin P, Royer CA, Cherfils J, Chavanieu A, Proc Natl Acad Sci U S A, 2007

2004

• Resonance assignments and topology of the 15N, 13C labelled 23 kDa core domain of xenopus Mob1

  Ponchon L, Dumas C, Fesquet D, Padilla A, J Biomol NMR, 2004

• NMR solution structure of Mob1, a mitotic exit network protein and its interaction with an NDR kinase peptide

  Ponchon L, Dumas C, Kajava AV, Fesquet D, Padilla A, J Mol Biol, 2004

• Crystal Structure of the Coiled-coil Dimerization Motif of Geminin: Structural and Functional Insights on DNA Replication Regulation

  Thepaut M, Maiorano D, Guichou JF, Auge MT, Dumas C, Mechali M, Padilla A, J Mol Biol, 2004

2002

• Crystallization and preliminary X-ray crystallographic analysis of human Geminin coiled-coil domain

  Thepaut M, Hoh F, Dumas C, Calas B, Strub MP, Padilla A, Biochim Biophys Acta, 2002

2001

• Structure of rat parvalbumin with deleted AB domain: implications for the evolution of EF hand calcium-binding proteins and possible physiological relevance

  Thepaut M, Strub MP, Cave A, Baneres JL, Berchtold MW, Dumas C, Padilla A, Proteins, 2001

• Biochemical characterization of the helper component of Cauliflower mosaic virus

  Hebrard E, Drucker M, Leclerc D, Hohn T, Uzest M, Froissart R, Strub JM, Sanglier S, van Dorsselaer A, Padilla A, Labesse G, Blanc S, J Virol, 2001

2000

• Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data

  Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C, J Biomol NMR, 2000

1999

• Two well-defined motifs in the cAMP-dependent protein kinase inhibitor (PKIalpha) correlate with inhibitory and nuclear export function

  Hauer JA, Barthe P, Taylor SS, Parello J, Padilla A, Protein Sci., 1999

1998

• 15N NMR relaxation studies of calcium-loaded parvalbumin show tight dynamics compared to those of other EF-hand proteins

  Baldellon C, Alattia JR, Strub MP, Pauls T, Berchtold MW, Cave A, Padilla A, Biochemistry, 1998

• Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology

  Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H, Structure, 1998

• Solution structure of the recombinant human oncoprotein p13MTCP1

  Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C, J Biomol NMR, 1998

1997

• HIV-1 Nef protein: purification, crystallizations, and preliminary X-ray diffraction studies

  Franken P, Arold S, Padilla A, Bodeus M, Hoh F, Strub MP, Boyer M, Jullien M, Benarous R, Dumas C, Protein Sci, 1997

• Solution structure of synthetic peptide inhibitor and substrate of cAMP-dependent protein kinase. A study by 2D H NMR and molecular dynamics

  Padilla A, Hauer JA, Tsigelny I, Parello J, Taylor SS, J Pept Res, 1997

1996

• Assignment of 13C resonances and analysis of relaxation properties and internal dynamics of pike parvalbumin by 13C-NMR at natural abundance

  Alattia T, Padilla A, Cave A, Eur J Biochem, 1996

1993

• Solution conformation of a synthetic bis-headed inhibitor of trypsin and carboxypeptidase A: new structural alignment between the squash inhibitors and the potato carboxypeptidase inhibitor

  Chiche L, Heitz A, Padilla A, Le-Nguyen D, Castro B, Protein Eng, 1993

1991

• Study of the conformation in solution of the trypsin binding loop of the synthetic bis-headed inhibitor TCPI. Combination of distance geometry, distance driven dynamics and restrained molecular dynamics in water

  Chiche L, Heitz A, Padilla A, Le Nguyen D, Castro B, J Chim Phys Phys- Chim Biol, 1991