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Gilles Labesse



Centre de Biochimie Structurale

29, rue de Navacelles
F-34090 Montpellier Cedex

Tel: 33 04 67 41 77 12
Fax: 33 04 67 41 79 13

Axes de recherche

Etude de l'évolution des structures de protéines et des repliements.
Caractérisation structurales et fonctionnelles
de cibles thérapeutiques potentielles (M. tuberculosis, C. jejuni, ...).

Compétences Techniques

Modélisation macromoléculaire à basse identité de séquence (<25%).
Cristallogénèse et cristallographie

Mes publications

1: Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S (2014) 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: Synthesis, structural studies and cytotoxic activities, Eur J Med Chem 85C () 418-437 . PMID = 25108359 Pubmed

2: Moutin E, Compan V, Raynaud F, Clerte C, Bouquier N, Labesse G, Ferguson ML, Fagni L, Royer CA, Perroy J (2014) Stoichiometry of scaffold complexes in living neurons - DLC2 as a dimerization engine for GKAP, J Cell Sci () . PMID = 24938595 Pubmed

3: Sagnol S, Yang Y, Bessin Y, Allemand F, Hapkova I, Notarnicola C, Guichou JF, Faure S, Labesse G, de Santa Barbara P (2014) Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity, Nucleic Acids Res () . PMID = 25064856 Pubmed

4: Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV (2014) Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions, Antimicrob Agents Chemother 58 (5) 2798-806 . PMID = 24590482 Pubmed

5: Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV (2014) Oleoyl-Coenzyme A Regulates Interaction of Transcriptional Regulator RaaS (Rv1219c) with DNA in Mycobacteria, J Biol Chem () . PMID = 25012658 Pubmed

6: Vogelmann J, Le Gall A, Dejardin S, Allemand F, Gamot A, Labesse G, Cuvier O, Negre N, Cohen-Gonsaud M, Margeat E, Nollmann M (2014) Chromatin Insulator Factors Involved in Long-Range DNA Interactions and Their Role in the Folding of the Drosophila Genome, PLoS Genet 10 (8) e1004544 . PMID = 25165871 Pubmed

7: Amiable C, Pochet S, Padilla A, Labesse G, Kaminski PA (2013) N (6)-Substituted AMPs Inhibit Mammalian Deoxynucleotide N-Hydrolase DNPH1, PLoS ONE 8 (11) e80755 . PMID = 24260472 Pubmed

8: Kaminski PA, Labesse G (2013) Phosphodeoxyribosyltransferases, designed enzymes for deoxyribonucleotides synthesis, J Biol Chem 288 (9) 6534-41 . PMID = 23325804 Pubmed

9: Labesse G, Alexandre T, Vaupre L, Salard-Arnaud I, Him JL, Raynal B, Bron P, Munier-Lehmann H (2013) MgATP regulates allostery and fiber formation in IMPDHs, Structure 21 (6) 975-85 . PMID = 23643948 Pubmed

10: Manes G, Meunier I, Avila-Fernandez A, Banfi S, Le Meur G, Zanlonghi X, Corton M, Simonelli F, Brabet P, Labesse G, Audo I, Mohand-Said S, Zeitz C, Sahel JA, Weber M, Dollfus H, Dhaenens CM, Allorge D, De Baere E, Koenekoop RK, Kohl S, Cremers FP, Hollyfi (2013) Mutations in IMPG1 cause vitelliform macular dystrophies, Am J Hum Genet 93 (3) 571-8 . PMID = 23993198 Pubmed

11: Padilla A, Amiable C, Pochet S, Kaminski PA, Labesse G (2013) Structure of the oncoprotein Rcl bound to three nucleotide analogues, Acta Crystallogr D Biol Crystallogr 69 (Pt 2) 247-55 . PMID = 23385460 Pubmed

12: Delfosse V, Grimaldi M, Pons JL, Boulahtouf A, le Maire A, Cavailles V, Labesse G, Bourguet W, Balaguer P (2012) Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes, Proc Natl Acad Sci U S A 109 (37) 14930-14935 . PMID = 22927406 Pubmed

13: Gelin M, Poncet-Montange G, Assairi L, Morellato L, Huteau V, Dugue L, Dussurget O, Pochet S, Labesse G (2012) Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound., Structure 20 (6) 1107-17 . PMID = 22608967 Pubmed

14: Guichou JF, Labesse G (2012) Fragment and conquer: from structure to complexes to function., Structure 20 (10) 1617-9 . PMID = 23063007 Pubmed

15: Yang Y, Labesse G, Carrere-Kremer S, Esteves K, Kremer L, Cohen-Gonsaud M, Blanc-Potard AB (2012) The C-terminal domain of the virulence factor MgtC is a divergent ACT domain., J. Bacteriol. 194 (22) 6255-63 . PMID = 22984256 Pubmed

16: Gazanion E, Garcia D, Silvestre R, Gerard C, Guichou JF, Labesse G, Seveno M, Cordeiro-Da-Silva A, Ouaissi A, Sereno D, Vergnes B (2011) The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation, Mol Microbiol 82 (1) 21-38 . PMID = 21819459 Pubmed

17: Huang S, Cao J, Jiang M, Labesse G, Liu J, Pin JP, Rondard P (2011) Interdomain movements in metabotropic glutamate receptor activation, Proc Natl Acad Sci U S A 108 (37) 15480-15485 . PMID = 21896740 Pubmed

18: Labesse G, Benkali K, Salard-Arnaud I, Gilles AM, Munier-Lehmann H (2011) Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation, Nucleic Acids Res 39 (8) 3458-3472 . PMID = 21149268 Pubmed

19: le Maire A, Gelin M, Pochet S, Hoh F, Pirocchi M, Guichou JF, Ferrer JL, Labesse G (2011) In-plate protein crystallization, in situ ligand soaking and X-ray diffraction, Acta Crystallogr D Biol Crystallogr 67 (Pt 9) 747-755 . PMID = 21904027 Pubmed

20: Sitbon M, Biard-Piechaczyk M, Robert V, Briant L, Kohler S, Labesse G, Devaux C (2011) Montpellier infectious diseases (MID): 1st annual meeting (2011), Infect Genet Evol 11 (7) 1493-1498 . PMID = 21767666 Pubmed

21: Vigneron S, Gharbi-Ayachi A, Raymond AA, Burgess A, Labbe JC, Labesse G, Monsarrat B, Lorca T, Castro A (2011) Characterization of the mechanisms controlling Greatwall activity, Mol Cell Biol 31 (11) 2262-2275 . PMID = 21444715 Pubmed

22: Diouf B, Collazos A, Labesse G, Macari F, Choquet A, Clair P, Gauthier-Rouviere C, Guerineau NC, Jay P, Hollande F, Joubert D (2009) A 20-amino acid module of protein kinase C{epsilon} involved in translocation and selective targeting at cell-cell contacts, J Biol Chem 284 (28) 18808-18815 . PMID = 19429675 Pubmed

23: Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF (2009) ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity, Structure 17 (1) 139-146 . PMID = 19141290 Pubmed

24: Mann S, Colliandre L, Labesse G, Ploux O (2009) Inhibition of 7,8-diaminopelargonic acid aminotransferase from Mycobacterium tuberculosis by chiral and achiral anologs of its substrate: biological implications, Biochimie 91 (7) 826-834 . PMID = 19345718 Pubmed

25: Monnier C, Dode C, Fabre L, Teixeira L, Labesse G, Pin JP, Hardelin JP, Rondard P (2009) PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity, Hum Mol Genet 18 (1) 75-81 . PMID = 18826963 Pubmed

26: Pons JL, Labesse G (2009) @TOME-2: a new pipeline for comparative modeling of protein-ligand complexes, Nucleic Acids Res in press () . PMID = 19443448 Pubmed

27: Yang Y, Padilla A, Zhang C, Labesse G, Kaminski PA (2009) Structural characterization of the mammalian deoxynucleotide N-hydrolase Rcl and its stabilizing interactions with two inhibitors, J Mol Biol 394 (3) 435-447 . PMID = 19822152 Pubmed

28: Doan T, Martin L, Zorrilla S, Chaix D, Aymerich S, Labesse G, Declerck N (2008) A phospho-sugar binding domain homologous to NagB enzymes regulates the activity of the central glycolytic genes repressor, Proteins 71 (4) 2038-2050 . PMID = 18186488 Pubmed

29: Oezguen N, Zhou B, Negi SS, Ivanciuc O, Schein CH, Labesse G, Braun W (2008) Comprehensive 3D-modeling of allergenic proteins and amino acid composition of potential conformational IgE epitopes, Mol Immunol 45 (14) 3740-3747 . PMID = 18621419 Pubmed

30: Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y, Trinquet E, Labesse G, Pin JP, Liu J (2008) Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning, Embo J 27 (9) 1321-1332 . PMID = 18388862 Pubmed

31: Binet V, Duthey B, Lecaillon J, Vol C, Quoyer J, Labesse G, Pin JP, Prezeau L (2007) Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors, J Biol Chem 282 (16) 12154-12163 . PMID = 17310064 Pubmed

32: El Hajj H, Lebrun M, Arold ST, Vial H, Labesse G, Dubremetz JF (2007) ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii, PLoS Pathog 3 (2) e14 . PMID = 17305424 Pubmed

33: Poncet-Montange G, Assairi L, Arold ST, Pochet S, Labesse G (2007) NAD kinases use substrate-assisted catalysis for specific recognition of NAD, J Biol Chem (282) 47 . PMID = 17686780 Pubmed

34: Poncet-Montange G, Ducasse-Cabanot S, Quemard A, Labesse G, Cohen-Gonsaud M (2007) Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies, Acta Crystallogr D Biol Crystallogr 63 (Pt 8) 923-925 . PMID = 17642518 Pubmed

35: El Hajj H, Demey E, Poncet J, Lebrun M, Wu B, Galeotti N, Fourmaux MN, Mercereau-Puijalon O, Vial H, Labesse G, Dubremetz JF (2006) The ROP2 family of Toxoplasma gondii rhoptry proteins: proteomic and genomic characterization and molecular modeling, Proteomics 6 (21) 5773-5784 . PMID = 17022100 Pubmed

36: Ganem C, Miled C, Facca C, Valay JG, Labesse G, Ben Hassine S, Mann C, Faye G (2006) Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1, Mol Genet Genomics 275 (2) 136-147 . PMID = 16362371 Pubmed

37: Martin L, Catherinot V, Labesse G (2006) kinDOCK: a tool for comparative docking of protein kinase ligands, Nucleic Acids Res 34 (Web Server issu) W325-329 . PMID = 16845019 Pubmed

38: Ponchon L, Boulanger P, Labesse G, Letellier L (2006) The endonuclease domain of bacteriophage terminases belongs to the resolvase/integrase/ribonuclease H superfamily: a bioinformatics analysis validated by a functional study on bacteriophage T5, J Biol Chem 281 (9) 5829-5836 . PMID = 16377618 Pubmed

39: Rondard P, Liu J, Huang S, Malhaire F, Vol C, Pinault A, Labesse G, Pin JP (2006) Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors, J Biol Chem 281 (34) 24653-24661 . PMID = 16787923 Pubmed

40: Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM (2006) The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria, FEBS Lett 580 (13) 3018-3022 . PMID = 16674948 Pubmed

41: Blanc-Potard AW, Labesse G, Figueroa-Bossi N, Bossi L (2005) Mutation at the exit gate of the salmonella gyrase a subunit suppresses a defect in the gyrase B subunit, J Bacteriol 187 (19) 6841-6844 .

42: Bourdoncle A, Labesse G, Margueron R, Castet A, Cavailles V, Royer CA (2005) The nuclear receptor coactivator PGC-1alpha exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1, J Mol Biol 347 (5) 921-934 . PMID = 15784253 Pubmed

43: Cohen-Gonsaud M, Ducasse-Cabanot S, Quemard A, Labesse G (2005) Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change, Proteins 60 (3) 392-400 . PMID = 15977159 Pubmed

44: Douguet D, Munier-Lehmann H, Labesse G, Pochet S (2005) LEA3D: A Computer-Aided Ligand Design for Structure-Based Drug Design, J Med Chem 48 (7) 2457-2468 .

45: Hebrard E, Pinel-Galzi A, Catherinot V, Labesse G, Brugidou C, Fargette D (2005) Internal point mutations of the capsid modify the serotype of Rice yellow mottle virus, J Virol 79 (7) 4407-4414 .

46: Rouached H, Berthomieu P, El Kassis E, Cathala N, Catherinot V, Labesse G, Davidian JC, Fourcroy P (2005) Structural and functional analysis of the C-terminal STAS (sulfate transporter and anti-sigma antagonist) domain of the Arabidopsis thaliana sulfate transporter SULTR1.2, J Biol Chem 280 (16) 15976-15983 .

47: Barthe P, Cohen-Gonsaud M, Aldrian-Herrada G, Chavanieu A, Labesse G, Roumestand C (2004) Design of an amphipatic a-helical hairpin peptide, Comptes Rendus Chimie 7 (3-4) 249-252 .

48: Bolla JM, Saint N, Labesse G, Pages JM, Dumas C (2004) Crystallization and preliminary crystallographic studies of MOMP (major outer membrane protein) from Campylobacter jejuni, Acta Crystallogr D Biol Crystallogr 60 (Pt 12 Pt 2) 2349-2351 .

49: Cohen-Gonsaud M, Catherinot V, Labesse G, Douguet D (2004) From molecular modelling to drug design, Nucleid Acids and Molecular Biology, Vol 15, Practical Bioinformatics, Ed. by J.M. Bujnicki (2004) Springer-Verlag () 7-10 .

50: Cohen-Gonsaud M, Keep NH, Davies AP, Ward J, Henderson B, Labesse G (2004) Resuscitation-promoting factors possess a lysozyme-like domain, Trends in Biochemical Sciences 29 (1) 7-10 .

51: Ducasse-Cabanot S, Cohen-Gonsaud M, Marrakchi H, Nguyen M, Zerbib D, Bernadou J, Daffe M, Labesse G, Quemard A (2004) In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid, Antimicrob Agents Chemother 48 (1) 242-249 . PMID = 14693546 Pubmed

52: Ganem C, Devaux F, Torchet C, Jacq C, Quevillon-Cheruel S, Labesse G, Facca C, Faye G (2003) Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast, Embo J 22 (7) 1588-1598 . PMID = 12660165 Pubmed

53: Hoellerer MK, Noble ME, Labesse G, Campbell ID, Werner JM, Arold ST (2003) Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain, Structure (Camb) 11 (10) 1207-1217 . PMID = 14527389 Pubmed

54: Munier-Lehmann H, Pochet S, Dugue L, Dutruel O, Labesse G, Douget D (2003) Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors, Nucleosides Nucleotides Nucleic Acids 22 (5-8) 801-804 . PMID = 14565282 Pubmed

55: Quemard A, Labesse G, Daffe M, Ducasse S, Cohen-Gonsaud M, Douguet D, Marrakchi H (2003) Use of the Protein MABA (FABG1) of MYCOBACTERIUM TUBERCULOSIS for designing and screening antibiotics, WO03082911 (28th march 2003) .

56: Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A (2002) Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis, J Mol Biol 320 (2) 249-261 . PMID = 12079383 Pubmed

57: Douguet D, Bolla J-M, Munier-Lehmann H, Labesse G (2002) From sequence to structure to function: a case study, Enzyme and Microbial Technology 30 (3) 289-294 .

58: Kniazeff J, Galvez T, Labesse G, Pin JP (2002) No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits, J Neurosci 22 (17) 7352-7361 . PMID = 12196556 Pubmed

59: Labesse G, Bucurenci N, Douguet D, Sakamoto H, Landais S, Gagyi C, Gilles AM, Barzu O (2002) Comparative modelling and immunochemical reactivity of Escherichia coli UMP kinase, Biochem Biophys Res Commun 294 (1) 173-179 . PMID = 12054759 Pubmed

60: Labesse G, Douguet D, Assairi L, Gilles AM (2002) Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases, Trends Biochem Sci 27 (6) 273-275 . PMID = 12069781 Pubmed

61: Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffe M, Quemard A (2002) MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II, Microbiology 148 (Pt 4) 951-960 . PMID = 11932442 Pubmed

62: Pochet S, Dugue L, Douguet D, Labesse G, Munier-Lehmann H (2002) Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications, Chembiochem 3 (1) 108-110 . PMID = 17590962 Pubmed

63: Saveanu C, Miron S, Borza T, Craescu CT, Labesse G, Gagyi C, Popescu A, Schaeffer F, Namane A, Laurent-Winter C, Barzu O, Gilles AM (2002) Structural and nucleotide-binding properties of YajQ and YnaF, two Escherichia coli proteins of unknown function, Protein Sci 11 (11) 2551-2560 . PMID = 12381839 Pubmed

64: Douguet D, Labesse G (2001) Easier threading through web-based comparisons and cross-validations, Bioinformatics 17 (8) 752-753 . PMID = 11524382 Pubmed

65: Hebrard E, Drucker M, Leclerc D, Hohn T, Uzest M, Froissart R, Strub JM, Sanglier S, van Dorsselaer A, Padilla A, Labesse G, Blanc S (2001) Biochemical characterization of the helper component of Cauliflower mosaic virus, J Virol 75 (18) 8538-8546 . PMID = 11507199 Pubmed

66: Labesse G, Douguet D, Gracy J, Pons J, Chiche L (2001) Stepwise modelling optimization from sequence to quaternary structure, 4th European Symposium of The Protein Society 10 () 140 .

67: Labesse G, Garnotel E, Bonnel S, Dumas C, Pages JM, Bolla JM (2001) MOMP, a divergent porin from Campylobacter: cloning and primary structural characterization, Biochem Biophys Res Commun 280 (1) 380-387 . PMID = 11162527 Pubmed

68: Munier-Lehmann H, Chaffotte A, Pochet S, Labesse G (2001) Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes, Protein Sci 10 (6) 1195-1205 . PMID = 11369858 Pubmed

69: De E, Jullien M, Labesse G, Pages JM, Molle G, Bolla JM (2000) MOMP (major outer membrane protein) of Campylobacter jejuni; a versatile pore-forming protein, FEBS Lett 469 (1) 93-97 . PMID = 10708763 Pubmed

70: Laurent F, Labesse G, de Wit P (2000) Molecular cloning and partial characterization of a plant VAP33 homologue with a major sperm protein domain, Biochem Biophys Res Commun 270 (1) 286-292 . PMID = 10733941 Pubmed

71: Carret C, Delbecq S, Labesse G, Carcy B, Precigout E, Moubri K, Schetters TP, Gorenflot A (1999) Characterization and molecular cloning of an adenosine kinase from Babesia canis rossi, Eur J Biochem 265 (3) 1015-1021 . PMID = 10518797 Pubmed

72: Girault JA, Labesse G, Mornon JP, Callebaut I (1999) The N-termini of FAK and JAKs contain divergent band 4.1 domains, Trends Biochem Sci 24 (2) 54-57 . PMID = 10098398 Pubmed

73: Poupon A, Jebai F, Labesse G, Gros F, Thibault J, Mornon JP, Krieger M (1999) Structure modelling and site-directed mutagenesis of the rat aromatic L-amino acid pyridoxal 5'-phosphate-dependent decarboxylase: a functional study, Proteins 37 (2) 191-203 . PMID = 10584065 Pubmed

74: Wojcik J, Girault JA, Labesse G, Chomilier J, Mornon JP, Callebaut I (1999) Sequence analysis identifies a ras-associating (RA)-like domain in the N-termini of band 4.1/JEF domains and in the Grb7/10/14 adapter family, Biochem Biophys Res Commun 259 (1) 113-120 . PMID = 10334925 Pubmed

75: Girault JA, Labesse G, Mornon JP, Callebaut I (1998) Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transduction, Mol Med 4 (12) 751-769 . PMID = 9990861 Pubmed

76: Hung IH, Casareno RL, Labesse G, Mathews FS, Gitlin JD (1998) HAH1 is a copper-binding protein with distinct amino acid residues mediating copper homeostasis and antioxidant defense, J Biol Chem 273 (3) 1749-1754 . PMID = 9430722 Pubmed

77: Labesse G, Craescu CT, Mispelter J, Chottard G, Marden MC, Pin S, Forest E, Mornon JP, Boccara M (1998) Engineering, expression and biochemical characterization of the hemoglobin domain of a Erwinia chrysanthemi flavohemoprotein, Eur J Biochem 253 (3) 751-759 . PMID = 9654075 Pubmed

78: Labesse G, Ferrari D, Chen ZW, Rossi GL, Kuusk V, McIntire WS, Mathews FS (1998) Crystallographic and spectroscopic studies of native, aminoquinol, and monovalent cation-bound forms of methylamine dehydrogenase from Methylobacterium extorquens AM1, J Biol Chem 273 (40) 25703-25712 . PMID = 9748238 Pubmed

79: Labesse G, Mornon J (1998) Incremental threading optimization (TITO) to help alignment and modelling of remote homologues, Bioinformatics 14 (2) 206-211 . PMID = 9545453 Pubmed

80: Callebaut I, Labesse G, Durand P, Poupon A, Canard L, Chomilier J, Henrissat B, Mornon JP (1997) Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives, Cell Mol Life Sci 53 (8) 621-645 . PMID = 9351466 Pubmed

81: Labesse G, Colloc'h N, Pothier J, Mornon JP (1997) P-SEA: a new efficient assignment of secondary structure from C alpha trace of proteins, Comput Appl Biosci 13 (3) 291-295 . PMID = 9183534 Pubmed

82: Bucurenci N, Sakamoto H, Briozzo P, Palibroda N, Serina L, Sarfati RS, Labesse G, Briand G, Danchin A, Barzu O, Gilles AM (1996) CMP kinase from Escherichia coli is structurally related to other nucleoside monophosphate kinases, J Biol Chem 271 (5) 2856-2862 . PMID = 8576266 Pubmed

83: Labesse G (1996) MulBlast 1.0: a multiple alignment of BLAST output to boost protein sequence similarity analysis, Comput Appl Biosci 12 (6) 463-467 . PMID = 9021263 Pubmed

84: Cantalloube H, Labesse G, Chomilier J, Nahum C, Cho YY, Chams V, Achour A, Lachgar A, Mbika JP, Issing W, et al. (1995) Automat and BLAST: comparison of two protein sequence similarity search programs, Comput Appl Biosci 11 (3) 261-272 . PMID = 7583694 Pubmed

85: Favey S, Labesse G, Vouille V, Boccara M (1995) Flavohaemoglobin HmpX: a new pathogenicity determinant in Erwinia chrysanthemi strain 3937, Microbiology 141 ( Pt 4 () 863-871 . PMID = 7773389 Pubmed

86: Labesse G, Vidal-Cros A, Chomilier J, Gaudry M, Mornon JP (1994) Structural comparisons lead to the definition of a new superfamily of NAD(P)(H)-accepting oxidoreductases: the single-domain reductases/epimerases/dehydrogenases (the 'RED' family), Biochem J 304 ( Pt 1 () 95-99 . PMID = 7998963 Pubmed

87: Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M (1994) Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing, Eur J Biochem 219 (3) 985-992 . PMID = 8112349 Pubmed

88: Laurent F, Kotoujansky A, Labesse G, Bertheau Y (1993) Characterization and overexpression of the pem gene encoding pectin methylesterase of Erwinia chrysanthemi strain 3937, Gene 131 (1) 17-25 . PMID = 8370537 Pubmed


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