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Catherine Royer

DR2 - INSERM

Email:
Catherine.Royercbs.cnrs.fr

Centre de Biochimie Structurale
29, route de Navacelles
34090 Montpellier CEDEX
France

Tel: 33 04 67 41 79 02
Fax: 33 04 67 41 79 13



Axes de recherche

Repliement des protéines: Etudes sous hautes pression
Interactions des Récepteurs Nucléaires
Dynamique Structurale des ARN



Compétences Techniques

fluorescence statique, résolue en temps et de corrélation
Analyse numérique des données d'interaction
Biochimie préparative



Mes publications

1: Moutin E, Compan V, Raynaud F, Clerte C, Bouquier N, Labesse G, Ferguson ML, Fagni L, Royer CA, Perroy J (2014) Stoichiometry of scaffold complexes in living neurons - DLC2 as a dimerization engine for GKAP, J Cell Sci () . PMID = 24938595 Pubmed

2: Declerck N, Royer CA (2013) Interactions in gene expression networks studied by two-photon fluorescence fluctuation spectroscopy, Meth Enzymol 519 () 203-30 . PMID = 23280112 Pubmed

3: Dellarole M, Kobayashi K, Rouget JB, Caro JA, Roche J, Islam MM, Garcia-Moreno E B, Kuroda Y, Royer CA (2013) Probing the physical determinants of thermal expansion of folded proteins, J Phys Chem B 117 (42) 12742-9 . PMID = 23646824 Pubmed

4: Dellarole M, Roumestand C, Royer C, Lecomte JT (2013) Volumetric properties underlying ligand binding in a monomeric hemoglobin: a high-pressure NMR study, Biochim Biophys Acta 1834 (9) 1910-22 . PMID = 23619242 Pubmed

5: Docquier A, Garcia A, Savatier J, Boulahtouf A, Bonnet S, Bellet V, Busson M, Margeat E, Jalaguier S, Royer C, Balaguer P, Cavailles V (2013) Negative regulation of estrogen signaling by ERβ and RIP140 in ovarian cancer cells, Mol Endocrinol 27 (9) 1429-41 . PMID = 23885094 Pubmed

6: Fiche JB, Cattoni DI, Diekmann N, Langerak JM, Clerte C, Royer CA, Margeat E, Doan T, Nollmann M (2013) Recruitment, assembly, and molecular architecture of the SpoIIIE DNA pump revealed by superresolution microscopy, PLoS Biol 11 (5) e1001557 . PMID = 23667326 Pubmed

7: Guca E, Roumestand C, Vallone B, Royer CA, Dellarole M (2013) Low-cost equilibrium unfolding of heme proteins using 2 μl samples, Anal Biochem 443 (1) 13-5 . PMID = 23958270 Pubmed

8: Roche J, Caro JA, Dellarole M, Guca E, Royer CA, Garcia-Moreno BE, Garcia AE, Roumestand C (2013) Structural, energetic, and dynamic responses of the native state ensemble of staphylococcal nuclease to cavity-creating mutations, Proteins 81 (6) 1069-80 . PMID = 23239146 Pubmed

9: Roche J, Dellarole M, Caro JA, Norberto DR, Garcia AE, Garcia-Moreno B, Roumestand C, Royer CA (2013) Effect of internal cavities on folding rates and routes revealed by real-time pressure-jump NMR spectroscopy, J Am Chem Soc 135 (39) 14610-8 . PMID = 23987660 Pubmed

10: Sibille N, Dellarole M, Royer C, Roumestand C (2013) Measuring residual dipolar couplings at high hydrostatic pressure: robustness of alignment media to high pressure, J Biomol NMR () . PMID = 24292655 Pubmed

11: Ferguson ML, Le Coq D, Jules M, Aymerich S, Declerck N, Royer CA (2012) Absolute quantification of gene expression in individual bacterial cells using two-photon fluctuation microscopy, Anal Biochem 419 (2) 250-259 . PMID = 21907700 Pubmed

12: Ferguson ML, Le Coq D, Jules M, Aymerich S, Radulescu O, Declerck N, Royer CA (2012) Reconciling molecular regulatory mechanisms with noise patterns of bacterial metabolic promoters in induced and repressed states, Proc Natl Acad Sci U S A 109 (1) 155-160 . PMID = 22190493 Pubmed

13: Roche J, Caro JA, Norberto DR, Barthe P, Roumestand C, Schlessman JL, Garcia AE, Garcia-Moreno BE, Royer CA (2012) Cavities determine the pressure unfolding of proteins, Proc Natl Acad Sci U S A 109 (18) 6945-6950 . PMID = 22496593 Pubmed

14: Roche J, Dellarole M, Caro JA, Guca E, Norberto DR, Yang Y, Garcia AE, Roumestand C, Garcia-Moreno B, Royer CA (2012) Remodeling of the folding free energy landscape of staphylococcal nuclease by cavity-creating mutations., Biochemistry 51 (47) 9535-46 . PMID = 23116341 Pubmed

15: Kitahara R, Hata K, Maeno A, Akasaka K, Chimenti MS, Garcia-Moreno EB, Schroer MA, Jeworrek C, Tolan M, Winter R, Roche J, Roumestand C, Montet de Guillen K, Royer CA (2011) Structural plasticity of staphylococcal nuclease probed by perturbation with pressure and pH, Proteins 79 (4) 1293-1305 . PMID = 21254234 Pubmed

16: Rouget JB, Aksel T, Roche J, Saldana JL, Garcia AE, Barrick D, Royer CA (2011) Size and sequence and the volume change of protein folding, J Am Chem Soc 133 (15) 6020-6027 . PMID = 21446709 Pubmed

17: Winter R, Royer C (2011) Protein hydration and volumetric properties, Curr Op Coll Inter Sci. () .

18: Chaix D, Ferguson ML, Atmanene C, Van Dorsselaer A, Sanglier-Cianferani S, Royer CA, Declerck N (2010) Physical basis of the inducer-dependent cooperativity of the Central glycolytic genes Repressor/DNA complex, Nucleic Acids Res () . PMID = 20462860 Pubmed

19: le Maire A, Teyssier C, Erb C, Grimaldi M, Alvarez S, de Lera AR, Balaguer P, Gronemeyer H, Royer CA, Germain P, Bourguet W (2010) A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor, Nat Struct Mol Biol 17 (7) 801-807 . PMID = 20543827 Pubmed

20: Rouget JB, Schroer MA, Jeworrek C, Puhse M, Saldana JL, Bessin Y, Tolan M, Barrick D, Winter R, Royer CA (2010) Unique features of the folding landscape of a repeat protein revealed by pressure perturbation, Biophys J 98 (11) 2712-2721 . PMID = 20513416 Pubmed

21: Savatier J, Jalaguier S, Ferguson ML, Cavailles V, Royer CA (2010) Estrogen receptor interactions and dynamics monitored in live cells by fluorescence cross-correlation spectroscopy, Biochemistry 49 (4) 772-781 . PMID = 20039662 Pubmed

22: Schroer M, Paulus M, Jeworrek C, Krywka C, Schmacke S, Zhai Y, Wieland D, Sahle C, Chimenti M, Royer C, Garcia-Moreno B, Tolan M, Winter R (2010) High-pressure SAXS study of folded and unfolded ensembles of proteins, Biophys J. 99 (10) 3430-3437 .

23: Germain P, Gaudon C, Pogenberg V, Sanglier S, Van Dorsselaer A, Royer CA, Lazar MA, Bourguet W, Gronemeyer H (2009) Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists, Chem Biol 16 (5) 479-489 . PMID = 19477412 Pubmed

24: Blin G, Margeat E, Carvalho K, Royer CA, Roy C, Picart C (2008) Quantitative analysis of the binding of ezrin to large unilamellar vesicles containing phosphatidylinositol 4,5 bisphosphate, Biophys J 94 (3) 1021-1033 . PMID = 17827228 Pubmed

25: Espenel C, Margeat E, Dosset P, Arduise C, Le Grimellec C, Royer CA, Boucheix C, Rubinstein E, Milhiet PE (2008) Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web, J Cell Biol 182 (4) 765-776 . PMID = 18710926 Pubmed

26: Krywka C, Sternemann C, Paulus M, Tolan M, Royer CA, Winter R (2008) Effect of osmolytes on pressure-induced unfolding of proteins: a high-pressure SAXS study, Chem Phys Chem 9 (18) 2809-2815 .

27: Mitra L, Rouget JB, Garcia-Moreno B, Royer CA, Winter R (2008) Towards a quantitative understanding of protein hydration and volumetric properties, Chemphyschem 9 (18) 2715-2721 . PMID = 18814170 Pubmed

28: Rosales T, Royer CA (2008) A graphical user interface for BIOEQS: a program for simulating and analyzing complex biomolecular interactions, Anal Biochem 381 (2) 270-272 . PMID = 18644343 Pubmed

29: Royer CA (2008) The nature of the transition state ensemble and the mechanisms of protein folding: a review, Arch Biochem Biophys 469 (1) 34-45 . PMID = 17923105 Pubmed

30: Royer CA, Scarlata SF (2008) Fluorescence approaches to quantifying biomolecular interactions, Methods Enzymol 450 () 79-106 . PMID = 19152857 Pubmed

31: Zorrilla S, Lillo MP, Chaix D, Margeat E, Royer CA, Declerck N (2008) Investigating transcriptional regulation by fluorescence spectroscopy, from traditional methods to state-of-the-art single-molecule approaches, Ann N Y Acad Sci 1130 () 44-51 . PMID = 18596330 Pubmed

32: Zorrilla S, Ortega A, Chaix D, Alfonso C, Rivas G, Aymerich S, Lillo MP, Declerck N, Royer CA (2008) Characterization of the control catabolite protein of gluconeogenic genes repressor by fluorescence cross-correlation spectroscopy and other biophysical approaches, Biophys J 95 (9) 4403-4415 . PMID = 18658229 Pubmed

33: Allemand F, Haentjens J, Chiaruttini C, Royer CA, Springer M (2007) Escherichia coli ribosomal protein L20 binds as a single monomer to its own mRNA bearing two potential binding sites, Nucleic Acids Res 35 (9) 3016-3031 . PMID = 17439971 Pubmed

34: Mitra L, Hata K, Kono R, Maeno A, Isom D, Rouget JB, Winter R, Akasaka K, Garcia-Moreno B, Royer CA (2007) V(i)-value analysis: a pressure-based method for mapping the folding transition state ensemble of proteins, J Am Chem Soc 129 (46) 14108-14109 . PMID = 17960902 Pubmed

35: Nahoum V, Perez E, Germain P, Rodriguez-Barrios F, Manzo F, Kammerer S, Lemaire G, Hirsch O, Royer CA, Gronemeyer H, de Lera AR, Bourguet W (2007) Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function, Proc Natl Acad Sci U S A 104 (44) 17323-17328 . PMID = 17947383 Pubmed

36: Rosales T, Georget V, Malide D, Smirnov A, Xu J, Combs C, Knutson JR, Nicolas JC, Royer CA (2007) Quantitative detection of the ligand-dependent interaction between the androgen receptor and the co-activator, Tif2, in live cells using two color, two photon fluorescence cross-correlation spectroscopy, Eur Biophys J 36 (2) 153-161 . PMID = 17021805 Pubmed

37: Viaud J, Zeghouf M, Barelli H, Zeeh JC, Padilla A, Guibert B, Chardin P, Royer CA, Cherfils J, Chavanieu A (2007) Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes, Proc Natl Acad Sci U S A 104 (25) 10370-10375 . PMID = 17563369 Pubmed

38: Zorrilla S, Chaix D, Ortega A, Alfonso C, Doan T, Margeat E, Rivas G, Aymerich S, Declerck N, Royer CA (2007) Fructose-1,6-bisphosphate acts both as an inducer and as a structural cofactor of the central glycolytic genes repressor (CggR), Biochemistry 46 (51) 14996-15008 . PMID = 18052209 Pubmed

39: Zorrilla S, Doan T, Alfonso C, Margeat E, Ortega A, Rivas G, Aymerich S, Royer CA, Declerck N (2007) Inducer-modulated cooperative binding of the tetrameric CggR repressor to operator DNA, Biophys J 92 (9) 3215-3227 . PMID = 17293407 Pubmed

40: Brun L, Isom DG, Velu P, Garcia-Moreno B, Royer CA (2006) Hydration of the folding transition state ensemble of a protein, Biochemistry 45 (11) 3473-3480 . PMID = 16533028 Pubmed

41: Mitra L, Smolin N, Ravindra R, Royer CA, Winter R (2006) Pressure perturbation calorimetric studies of the solvation properties and the thermal unfolding of proteins in solution--experiments and theoretical interpretation, Phys Chem Chem Phys 8 (11) 1249-1265 . PMID = 16633605 Pubmed

42: Royer CA (2006) Probing protein folding and conformational transitions with fluorescence, Chem Rev 106 (5) 1769-1784 . PMID = 16683754 Pubmed

43: Margeat E, Boukari H, Royer CA (2006) The Characterization of Bio-molecular Interactions Using Fluorescence Fluctuation Techniques, Protein Interactions () . PMID = Pubmed

44: Bourdoncle A, Labesse G, Margueron R, Castet A, Cavailles V, Royer CA (2005) The nuclear receptor coactivator PGC-1alpha exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1, J Mol Biol 347 (5) 921-934 . PMID = 15784253 Pubmed

45: Guillier M, Allemand F, Dardel F, Royer CA, Springer M, Chiaruttini C (2005) Double molecular mimicry in Escherichia coli: Binding of ribosomal protein L20 to its two sites in mRNA is similar to its binding to 23S rRNA, Mol Microbiol 56 (6) 1441-1456 .

46: Jackler G, Czeslik C, Steitz R, Royer CA (2005) Spatial distribution of protein molecules adsorbed at a polyelectrolyte multilayer, Physical Review E 71 (4 Pt 1) 041912 .

47: Pogenberg V, Guichou JF, Vivat-Hannah V, Kammerer S, Perez E, Germain P, de Lera AR, Gronemeyer H, Royer CA, Bourguet W (2005) Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies, J Biol Chem 280 (2) 1625-1633 . PMID = 15528208 Pubmed

48: Stricher F, Martin L, Barthe P, Pogenberg V, Mechulam A, Menez A, Roumestand C, Veas F, Royer C, Vita C (2005) A high-throughput fluorescence polarization assay specific to the CD4 binding site of HIV-1 glycoproteins based on a fluorescein-labelled CD4 mimic, Biochem J 390 (Pt 1) 29-39 . PMID = 15836438 Pubmed

49: Auguin D, Barthe P, Royer C, Stern MH, Noguchi M, Arold ST, Roumestand C (2004) Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins, J Biol Chem 279 (34) 35890-35902 . PMID = 15169787 Pubmed

50: Czeslik C, Jansen R, Ballauff M, Wittemann A, Royer CA, Gratton E, Hazlett T (2004) Mechanism of protein binding to spherical polyelectrolyte brushes studied in situ using two-photon excitation fluorescence fluctuation spectroscopy, Phys Rev E Stat Nonlin Soft Matter Phys 69 (2 Pt 1) 021401 .

51: Herberhold H, Royer CA, Winter R (2004) Effects of chaotropic and kosmotropic cosolvents on the pressure-induced unfolding and denaturation of proteins: an FT-IR study on staphylococcal nuclease, Biochemistry 43 (12) 3336-3345 . PMID = 15035605 Pubmed

52: Bayley P, Martin S, Browne P, Royer C (2003) Time-resolved fluorescence anisotropy studies show domain-specific interactions of calmodulin with IQ target sequences of myosin V, Eur Biophys J 32 (2) 122-127 . PMID = 12734700 Pubmed

53: Czeslik C, Royer C, Hazlett T, Mantulin W (2003) Reorientational Dynamics of Enzymes Adsorbed on Quartz: A Temperature- Dependent Time-Resolved TIRF Anisotropy Study, Biophys J 84 (4) 2533-2541 . PMID = 12668461 Pubmed

54: Margeat E, Bourdoncle A, Margueron R, Poujol N, Cavailles V, Royer C (2003) Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta, J Mol Biol 326 (1) 77-92 . PMID = 12547192 Pubmed

55: Poujol N, Margeat E, Baud S, Royer CA (2003) RAR Antagonists Diminish the Level of DNA Binding by the RAR/RXR Heterodimer, Biochemistry 42 (17) 4918-4925 . PMID = 12718533 Pubmed

56: Van Uden NWA, Hubel H, Faux DA, Dunstan DJ, Royer CA (2003) Negative Effective PRessures in Miquid Mixtures, High Pressure Research 23 (3) 205-209 .

57: Baud S, Margeat E, Lumbroso S, Paris F, Sultan C, Royer C, Poujol N (2002) Equilibrium binding assays reveal the elevated stoichiometry and salt dependence of the interaction between full-length human sex-determining region on the Y chromosome (SRY) and DNA, J Biol Chem 277 (21) 18404-18410 . PMID = 11877434 Pubmed

58: Kitahara R, Royer C, Yamada H, Boyer M, Saldana JL, Akasaka K, Roumestand C (2002) Equilibrium and pressure-jump relaxation studies of the conformational transitions of P13MTCP1, J Mol Biol 320 (3) 609-628 . PMID = 12096913 Pubmed

59: Maleki SJ, Royer CA, Hurlburt BK (2002) Analysis of the DNA-binding properties of MyoD, myogenin, and E12 by fluorescence anisotropy, Biochemistry 41 (35) 10888-10894 . PMID = 12196028 Pubmed

60: Royer CA (2002) Revisiting volume changes in pressure-induced protein unfolding, Biochim Biophys Acta 1595 (1-2) 201-209 . PMID = 11983396 Pubmed

61: Twist C, Royer C, Alpert B (2002) Effect of solvent diffusion on the apomyoglobin-water interface, Biochemistry 41 (32) 10343-10350 . PMID = 12162750 Pubmed

62: Royer CA (2002) A discussion of the physical basis for the pressure unfolding of proteins, Trends in HIgh pressure Bioscience and Biotechnology () 17-25 . PMID = Pubmed

63: Declerck N, Dutartre H, Receveur V, Dubois V, Royer C, Aymerich S, van Tilbeurgh H (2001) Dimer stabilization upon activation of the transcriptional antiterminator LicT, J Mol Biol 314 (4) 671-681 . PMID = 11733988 Pubmed

64: Margeat E, Poujol N, Boulahtouf A, Chen Y, Muller JD, Gratton E, Cavailles V, Royer CA (2001) The human estrogen receptor alpha dimer binds a single SRC-1 coactivator molecule with an affinity dictated by agonist structure, J Mol Biol 306 (3) 433-442 . PMID = 11178903 Pubmed

65: Roumestand C, Boyer M, Guignard L, Barthe P, Royer CA (2001) Characterization of the folding and unfolding reactions of a small beta-barrel protein of novel topology, the MTCP1 oncogene product P13, J. Mol. Biol. 312 (1) 247-259 . PMID = 11545600 Pubmed

66: Seemann H, Winter R, Royer CA (2001) Volume, expansivity and isothermal compressibility changes associated with temperature and pressure unfolding of Staphylococcal nuclease, J Mol Biol 307 (4) 1091-1102 . PMID = 11286558 Pubmed

67: Silva JL, Foguel D, Royer CA (2001) Pressure provides new insights into protein folding, dynamics and structure, Trends Biochem Sci 26 (10) 612-618 . PMID = 11590014 Pubmed

68: Szatkowski Ozers M, Hill JJ, Ervin K, Royer CA, Gorski J (2001) The dissociation rate of estrogen receptor alpha from the consensus estrogen response element, Mol Cell Endocrinol 175 (1-2) 101-109 . PMID = 11325520 Pubmed

69: Woenckhaus J, Kohling R, Thiyagarajan P, Littrell KC, Seifert S, Royer CA, Winter R (2001) Pressure-jump small-angle x-ray scattering detected kinetics of staphylococcal nuclease folding, Biophys J 80 (3) 1518-1523 . PMID = 11222312 Pubmed

70: Royer CA (2001) Super-repressor, Encyclopedia of Genetics () 1896 . PMID = Pubmed

71: Boyer M, Poujol N, Margeat E, Royer CA (2000) Quantitative characterization of the interaction between purified human estrogen receptor alpha and DNA using fluorescence anisotropy, Nucleic Acids Res 28 (13) 2494-2502 . PMID = 10871398 Pubmed

72: Grillo AO, Royer CA (2000) The basis for the super-repressor phenotypes of the AV77 and EK18 mutants of trp repressor, J Mol Biol 295 (1) 17-28 . PMID = 10623505 Pubmed

73: Royer CA (2000) Protein folding and stability: What can we learn from high pressure?, High Pressure Res 19 () 213-222 .

74: Brown MP, Grillo AO, Boyer M, Royer CA (1999) Probing the role of water in the tryptophan repressor-operator complex, Protein Sci 8 (6) 1276-1285 . PMID = 10386877 Pubmed

75: Chae YK, Abildgaard F, Royer CA, Markley JL (1999) Oligomerization of the EK18 mutant of the trp repressor of Escherichia coli as observed by NMR spectroscopy, Arch Biochem Biophys 371 (1) 35-40 . PMID = 10525287 Pubmed

76: Desai G, Panick G, Zein M, Winter R, Royer CA (1999) Pressure-jump studies of the folding/unfolding of trp repressor, J Mol Biol 288 (3) 461-475 . PMID = 10329154 Pubmed

77: Grillo AO, Brown MP, Royer CA (1999) Probing the physical basis for trp repressor-operator recognition, J Mol Biol 287 (3) 539-554 . PMID = 10092458 Pubmed

78: Panick G, Vidugiris GJ, Malessa R, Rapp G, Winter R, Royer CA (1999) Exploring the temperature-pressure phase diagram of staphylococcal nuclease, Biochemistry 38 (13) 4157-4164 . PMID = 10194332 Pubmed

79: Strugnell SA, Hill JJ, McCaslin DR, Wiefling BA, Royer CA, DeLuca HF (1999) Bacterial expression and characterization of the ligand-binding domain of the vitamin D receptor, Arch Biochem Biophys 364 (1) 42-52 . PMID = 10087163 Pubmed

80: Thenot S, Bonnet S, Boulahtouf A, Margeat E, Royer CA, Borgna JL, Cavailles V (1999) Effect of ligand and DNA binding on the interaction between human transcription intermediary factor 1alpha and estrogen receptors, Mol Endocrinol 13 (12) 2137-2150 . PMID = 10598587 Pubmed

81: Frye KJ, Royer CA (1998) Probing the contribution of internal cavities to the volume change of protein unfolding under pressure, Protein Sci 7 (10) 2217-2222 . PMID = 9792110 Pubmed

82: Margeat E, Le Grimellec C, Royer CA (1998) Visualization of trp repressor and its complexes with DNA by atomic force microscopy, Biophys J 75 (6) 2712-2720 . PMID = 9826594 Pubmed

83: Panick G, Malessa R, Winter R, Rapp G, Frye KJ, Royer CA (1998) Structural characterization of the pressure-denatured state and unfolding/refolding kinetics of staphylococcal nuclease by synchrotron small-angle X-ray scattering and Fourier-transform infrared spectroscopy, J Mol Biol 275 (2) 389-402 . PMID = 9466917 Pubmed

84: Vangala S, Vidugiris GAJ, Royer CA (1998) Probing the relation between protein structure and instrinsic tryptophan fluorescence using super-repressor mutants of the trp repressor, J. Fluorescence 8 () 1-11 .

85: Vidugiris GJ, Royer CA (1998) Determination of the volume changes for pressure-induced transitions of apomyoglobin between the native, molten globule, and unfolded states, Biophys J 75 (1) 463-470 . PMID = 9649407 Pubmed

86: Frye KJ, Royer CA (1997) The kinetic basis for the stabilization of staphylococcal nuclease by xylose, Protein Sci 6 (4) 789-793 . PMID = 9098888 Pubmed

87: Hill JJ, Royer CA (1997) Fluorescence approaches to study of protein-nucleic acid complexation, Methods Enzymol 278 () 390-416 . PMID = 9170324 Pubmed

88: Maleki SJ, Royer CA, Hurlburt BK (1997) MyoD-E12 heterodimers and MyoD-MyoD homodimers are equally stable, Biochemistry 36 (22) 6762-6767 . PMID = 9184158 Pubmed

89: Ozers MS, Hill JJ, Ervin K, Wood JR, Nardulli AM, Royer CA, Gorski J (1997) Equilibrium binding of estrogen receptor with DNA using fluorescence anisotropy, J Biol Chem 272 (48) 30405-30411 . PMID = 9374531 Pubmed

90: Reedstrom RJ, Brown MP, Grillo A, Roen D, Royer CA (1997) Affinity and specificity of trp repressor-DNA interactions studied with fluorescent oligonucleotides, J Mol Biol 273 (3) 572-585 . PMID = 9356247 Pubmed

91: Frye KJ, Perman CS, Royer CA (1996) Testing the correlation between delta A and delta V of protein unfolding using m value mutants of staphylococcal nuclease, Biochemistry 35 (31) 10234-10239 . PMID = 8756489 Pubmed

92: Gratton E, Mantulin W, Weber G, Royer CA, Jameson DM, Reininger R, Hanson R (1996) Fluorescence dynamics of biological systems using synchrotron radiation, Rev Sci Instrum 67 () 1-9 .

93: Reedstrom RJ, Martin KS, Vangala S, Mahoney S, Wilker EW, Royer CA (1996) Characterization of charge change super-repressor mutants of trp repressor: effects on oligomerization conformation, ligation and stability, J Mol Biol 264 (1) 32-45 . PMID = 8950265 Pubmed

94: Sire O, Alpert B, Royer CA (1996) Probing pH and pressure effects on the apomyoglobin heme pocket with the 2'-(N,N-dimethylamino)-6-naphthoyl-4-trans-cyclohexanoic acid fluorophore, Biophys J 70 (6) 2903-2914 . PMID = 8744328 Pubmed

95: Vidugiris GJ, Thomas JL, Royer CA (1996) Pressure-jump relaxation kinetics of unfolding and refolding transitions of staphylococcal nuclease and proline isomerization mutants, High pressure effects in molecular biophysics and enzymology () .

96: Vidugiris GJ, Truckses DM, Markley JL, Royer CA (1996) High-pressure denaturation of staphylococcal nuclease proline-to- glycine substitution mutants, Biochemistry 35 (12) 3857-3864 . PMID = 8620010 Pubmed

97: Reedstrom RJ, Royer CA (1995) Evidence for coupling of folding and function in trp repressor: physical characterization of the superrepressor mutant AV77, J Mol Biol 253 (2) 266-276 . PMID = 7563088 Pubmed

98: Royer CA (1995) Fluorescence spectroscopy, Methods Mol Biol 40 () 65-89 . PMID = 7633532 Pubmed

99: Royer CA (1995) Application of pressure to biochemical equilibria: the other thermodynamic variable, Methods Enzymol 259 () 357-377 . PMID = 8538462 Pubmed

100: Royer CA (1995) Approaches to teaching fluorescence spectroscopy, Biophys J 68 (3) 1191-1195 . PMID = 7756538 Pubmed

101: Vidugiris GJ, Markley JL, Royer CA (1995) Evidence for a molten globule-like transition state in protein folding from determination of activation volumes, Biochemistry 34 (15) 4909-4912 . PMID = 7711012 Pubmed

102: Martin KS, Royer CA, Howard KP, Carey J, Liu YC, Matthews K, Heyduk E, Lee JC (1994) Electrostatic forces contribute to interactions between trp repressor dimers, Biophys J 66 (4) 1167-1172 . PMID = 8038388 Pubmed

103: Pin S, Royer CA (1994) High-pressure fluorescence methods for observing subunit dissociation in hemoglobin, Methods Enzymol 232 () 42-55 . PMID = 8057872 Pubmed

104: LeTilly V, Royer CA (1993) Fluorescence anisotropy assays implicate protein-protein interactions in regulating trp repressor DNA binding, Biochemistry 32 (30) 7753-7758 . PMID = 8347584 Pubmed

105: Mann CJ, Royer CA, Matthews CR (1993) Tryptophan replacements in the trp aporepressor from Escherichia coli: probing the equilibrium and kinetic folding models, Protein Sci 2 (11) 1853-1861 . PMID = 8268796 Pubmed

106: Royer CA (1993) Improvements in the numerical analysis of thermodynamic data from biomolecular complexes, Anal Biochem 210 (1) 91-97 . PMID = 8489028 Pubmed

107: Royer CA (1993) Understanding fluorescence decay in proteins, Biophys J 65 (1) 9-10 . PMID = 8369464 Pubmed

108: Royer CA, Hinck AP, Loh SN, Prehoda KE, Peng X, Jonas J, Markley JL (1993) Effects of amino acid substitutions on the pressure denaturation of staphylococcal nuclease as monitored by fluorescence and nuclear magnetic resonance spectroscopy, Biochemistry 32 (19) 5222-5232 . PMID = 8494899 Pubmed

109: Royer CA, Mann CJ, Matthews CR (1993) Resolution of the fluorescence equilibrium unfolding profile of trp aporepressor using single tryptophan mutants, Protein Sci 2 (11) 1844-1852 . PMID = 8268795 Pubmed

110: Fernando T, Royer C (1992) Role of protein--protein interactions in the regulation of transcription by trp repressor investigated by fluorescence spectroscopy, Biochemistry 31 (13) 3429-3441 . PMID = 1554725 Pubmed

111: Fernando T, Royer CA (1992) Unfolding of trp repressor studied using fluorescence spectroscopic techniques, Biochemistry 31 (29) 6683-6691 . PMID = 1637807 Pubmed

112: Moss ML, Palmer RE, Kuzmic P, Dunlap BE, Henzel W, Kofron JL, Mellon WS, Royer CA, Rich DH (1992) Identification of actin and HSP 70 as cyclosporin A binding proteins by photoaffinity labeling and fluorescence displacement assays, J Biol Chem 267 (31) 22054-22059 . PMID = 1429556 Pubmed

113: Royer CA (1992) Investigation of the structural determinants of the intrinsic fluorescence emission of the trp repressor using single tryptophan mutants, Biophys J 63 (3) 741-750 . PMID = 1420911 Pubmed

114: Royer CA, Beechem JM (1992) Numerical analysis of binding data: advantages, practical aspects, and implications, Methods Enzymol 210 () 481-505 . PMID = 1584048 Pubmed

115: Royer CA, LeTilly V, Martin KS (1992) Fluorescence Approaches to the Study of Protein-DNA Interactions, Time-resolved spectroscopy in Biochemistry III III () .

116: Royer CA, Ropp T, Scarlata SF (1992) Solution studies of the interactions between the histone core proteins and DNA using fluorescence spectroscopy, Biophys Chem 43 (2) 197-211 . PMID = 1307864 Pubmed

117: Royer CA (1991) Macromolecular assemblies studied using high pressure fluorescence spectroscopy, Time-resolved laser spectroscopy in Biochemistry II () 1202 .

118: Pin S, Royer CA, Gratton E, Alpert B, Weber G (1990) Subunit interactions in hemoglobin probed by fluorescence and high- pressure techniques, Biochemistry 29 (39) 9194-9202 . PMID = 2271588 Pubmed

119: Royer CA, Chakerian AE, Matthews KS (1990) Macromolecular binding equilibria in the lac repressor system: studies using high-pressure fluorescence spectroscopy, Biochemistry 29 (20) 4959-4966 . PMID = 2194564 Pubmed

120: Royer CA, Gardner JA, Beechem JM, Brochon JC, Matthews KS (1990) Resolution of the fluorescence decay of the two tryptophan residues of lac repressor using single tryptophan mutants, Biophys J 58 (2) 363-378 . PMID = 2207244 Pubmed

121: Royer CA, Smith WR, Beechem JM (1990) Analysis of binding in macromolecular complexes: a generalized numerical approach, Anal Biochem 191 (2) 287-294 . PMID = 2085174 Pubmed

122: Royer CA, Rusch RM, Scarlata SF (1989) Salt effects on histone subunit interactions as studied by fluorescence spectroscopy, Biochemistry 28 (16) 6631-6637 . PMID = 2790017 Pubmed

123: Scarlata SF, Ropp T, Royer CA (1989) Histone subunit interactions as investigated by high pressure, Biochemistry 28 (16) 6637-6641 . PMID = 2790018 Pubmed

124: Royer CA, Alpert B (1987) Porphyrin Dynamics in the Heme pockets of Myoglobin and Hemoglobin, Chem Phys Lett 134 () 454 .

125: Royer CA, Tauc P, Herve G, Brochon JC (1987) Ligand binding and protein dynamics: a fluorescence depolarization study of aspartate transcarbamylase from Escherichia coli, Biochemistry 26 (20) 6472-6478 . PMID = 3322381 Pubmed

126: Royer CA, Weber G, Daly TJ, Matthews KS (1986) Dissociation of the lactose repressor protein tetramer using high hydrostatic pressure, Biochemistry 25 (25) 8308-8315 . PMID = 3545291 Pubmed

127: Scarlata SF, Royer CA (1986) Ligand-induced asymmetry as observed through fluorophore rotations and free energy couplings: application to neurophysin, Biochemistry 25 (17) 4925-4929 . PMID = 3768323 Pubmed

 


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