Philippe Barthe
Structure, dynamique et fonction des biomolécules par RMN
04 67 41 77 08
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Liste des publications
2024
2023
Does a Similar 3D Structure Mean a Similar Folding Pathway? The Presence of a C-Terminal alpha-Helical Extension in the 3D Structure of MAX60 Drastically Changes the Folding Pathway Described for Other MAX-Effectors from Magnaporthe oryzae
Lahfa M, Mouhand A, deGuillen K, Barthe P, Kroj T, Padilla A, Roumestand C, Molecules, 2023
1H, 13C and 15N backbone and side-chain resonance assignments of BmSA1, the surface antigen of Babesia microti
Mouhand A, Pissarra J, Delbecq S, Roumestand C, Barthe P, Biomol NMR Assign, 2023
A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome cExit
Martin M, deVisch A, Boudehen YM, Barthe P, Gutierrez C, Turapov O, Aydogan T, Heriaud L, Gracy J, Neyrolles O, Mukamolova GV, Letourneur F, Cohen-Gonsaud M, Microbiol Spectr, 2023
2022
PYK2 senses calcium through a disordered dimerization and calmodulin-binding element
Momin AA, Mendes T, Barthe P, Faure C, Hong S, Yu P, Kadare G, Jaremko M, Girault JA, Jaremko , Arold ST, Commun Biol, 2022
1H, 13C, 15N backbone and side-chain NMR assignments for three MAX effectors from Magnaporthe oryzae
Lahfa M, Padilla A, deGuillen K, Pissarra J, Raji M, Cesari S, Kroj T, Gladieux P, Roumestand C, Barthe P, Biomol NMR Assign, 2022
Combining High-Pressure NMR and Geometrical Sampling to Obtain a Full Topological Description of Protein Folding Landscapes: Application to the Folding of Two MAX Effectors from Magnaporthe oryzae
Dubois C, Lahfa M, Pissarra J, deGuillen K, Barthe P, Kroj T, Roumestand C, Padilla A, Int J Mol Sci, 2022
2021
Comparative Assessment of NMR Probes for the Experimental Description of Protein Folding Pathways with High-Pressure NMR
Van Deuren V, Yang YS, deGuillen K, Dubois C, Royer CA, Roumestand C, Barthe P, Biology (Basel), 2021
The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
Labbe JC, Vigneron S, Mechali F, Robert P, Roque S, Genoud C, Goguet-Rubio P, Barthe P, Labesse G, Cohen-Gonsaud M, Castro A, Lorca T, Nat Commun, 2021
Pressure and Chemical Unfolding of an alpha-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1
Dubois C, Planelles-Herrero VJ, Tillatte-Tripodi C, Delbecq S, Mammri L, Sirkia EM, Ropars V, Roumestand C, Barthe P, Int J Mol Sci, 2021
2020
2019
Structural genomics applied to the rust fungus Melampsora larici-populina reveals two candidate effector proteins adopting cystine knot and NTF2-like protein folds
deGuillen K, Lorrain C, Tsan P, Barthe P, Petre B, Saveleva N, Rouhier N, Duplessis S, Padilla A, Hecker A, Sci Rep, 2019
Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112
Alqaseer K, Turapov O, Barthe P, Jagatia H, De Visch A, Roumestand C, Wegrzyn M, Bartek IL, Voskuil MI, O'Hare HM, Ajuh P, Bottrill AR, Witney AA, Cohen-Gonsaud M, Waddell SJ, Mukamolova GV, Mol Microbiol, 2019
Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression
Cordeiro TN, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, Bailly R, Vivat V, Ebel C, Barducci A, Bourguet W, le Maire A, Bernado P, Structure, 2019
Folding of the Ig-Like Domain of the Dengue Virus Envelope Protein Analyzed by High-Hydrostatic-Pressure NMR at a Residue-Level Resolution
Saotome T, Doret M, Kulkarni M, Yang YS, Barthe P, Kuroda Y, Roumestand C, Biomolecules, 2019
Structural basis for chemically-induced homodimerization of a single domain antibody
Lesne J, Chang HJ, De Visch A, Paloni M, Barthe P, Guichou JF, Mayonove P, Barducci A, Labesse G, Bonnet J, Cohen-Gonsaud M, Sci Rep, 2019
2018
Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis
Turapov O, Forti F, Kadhim B, Ghisotti D, Sassine J, Straatman-Iwanowska A, Bottrill AR, Moynihan PJ, Wallis R, Barthe P, Cohen-Gonsaud M, Ajuh P, Vollmer W, Mukamolova GV, Cell Rep, 2018
A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jager D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U, J Nucl Med, 2018
Monitoring Unfolding of Titin I27 Single and Bi Domain with High-Pressure NMR Spectroscopy
Herrada I, Barthe P, Vanheusden M, DeGuillen K, Mammri L, Delbecq S, Rico F, Roumestand C, Biophys J, 2018
2016
2015
Evolutionarily Conserved Pattern of Interactions in a Protein Revealed by Local Thermal Expansion Properties
Dellarole M, Caro JA, Roche J, Fossat M, Barthe P, Garcia-Moreno E B, Royer CA, Roumestand C, J Am Chem Soc, 2015
The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth
Turapov O, Loraine J, Jenkins CH, Barthe P, McFeely D, Forti F, Ghisotti D, Hesek D, Lee M, Bottrill AR, Vollmer W, Mobashery S, Cohen-Gonsaud M, Mukamolova GV, Open Biol, 2015
2013
1H, 1aN and 13C Backbone resonance assignments of a conformational mutant of the adhesion protein a-Bd37 from Babesia divergens
Barthe P, Murciano B, Schetters T, Gorenflot A, Delbecq S, Roumestand C, Biomol NMR Assign, 2013
Equivalence between Euler angle conventions for the description of tensorial interactions in liquid NMR: application to different software programs
Dosset P, Barthe P, Cohen-Gonsaud M, Roumestand C, Demene H, J Biomol NMR, 2013
A disulfide-constrained miniprotein with striking tumor-binding specificity developed by ribosome display
Zoller F, Markert A, Barthe P, Hebling U, Altmann A, Lindner T, Mier W, Haberkorn U, Angew Chem Int Ed Engl, 2013
2012
Cavities determine the pressure unfolding of proteins
Roche J, Caro JA, Norberto DR, Barthe P, Roumestand C, Schlessman JL, Garcia AE, Garcia-Moreno BE, Royer CA, Proc Natl Acad Sci U S A, 2012
Combination of phage display and molecular grafting generates highly specific tumor-targeting miniproteins.
Zoller F, Markert A, Barthe P, Zhao W, Weichert W, Askoxylakis V, Altmann A, Mier W, Haberkorn U, Angew. Chem. Int. Ed. Engl., 2012
2011
2010
2009
Dynamic and structural characterization of a bacterial FHA protein reveals a new autoinhibition mechanism
Barthe P, Roumestand C, Canova MJ, Kremer L, Hurard C, Molle V, Cohen-Gonsaud M, Structure, 2009
Structural studies of the complex between Akt-in and the Akt2-PH domain suggest that the peptide acts as an allosteric inhibitor of the Akt kinase
Ropars V, Barthe P, Wang CS, Chen W, Tzou DL, Descours A, Martin L, Noguchi M, Roumestand C, Open Spect J, 2009
The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation
Cohen-Gonsaud M, Barthe P, Canova MJ, Stagier-Simon C, Kremer L, Roumestand C, Molle V, J Biol Chem, 2009
2008
2007
Structural analysis of cassiicolin, a host-selective protein toxin from Corynespora cassiicola
Barthe P, Pujade-Renaud V, Breton F, Gargani D, Thai R, Roumestand C, de Lamotte F, J Mol Biol, 2007
Unraveling protein dynamics through fast spectral density mapping
Ropars V, Bouguet-Bonnet S, Auguin D, Barthe P, Canet D, Roumestand C, J Biomol NMR, 2007
2006
DYNAMOF: a program for the dynamics analysis of relaxation data obtained at multiple magnetic fields.
Barthe P, Ropars V, Roumestand C, C. R. Chimie, 2006
Structural basis for the Akt (PKB) kinase inhibition by the peptide Akt-in: an NMR study.
Ropars V, Guichou J-F, Auguin D, Barthe P, Noguchi M, Roumestand C, C. R. Chimie, 2006
2005
The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes
Cohen-Gonsaud M, Barthe P, Bagneris C, Henderson B, Ward J, Roumestand C, Keep NH, Nat Struct Mol Biol, 2005
Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth
Huang CC, Stricher F, Martin L, Decker JM, Majeed S, Barthe P, Hendrickson WA, Robinson J, Roumestand C, Sodroski J, Wyatt R, Shaw GM, Vita C, Kwong PD, Structure, 2005
A high-throughput fluorescence polarization assay specific to the CD4 binding site of HIV-1 glycoproteins based on a fluorescein-labelled CD4 mimic
Stricher F, Martin L, Barthe P, Pogenberg V, Mechulam A, Menez A, Roumestand C, Veas F, Royer C, Vita C, Biochem J, 2005
2004
Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates
Auguin D, Barthe P, Auge-Senegas MT, Stern MH, Noguchi M, Roumestand C, J Biomol NMR, 2004
Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins
Auguin D, Barthe P, Royer C, Stern MH, Noguchi M, Arold ST, Roumestand C, J Biol Chem, 2004
Design of an amphipatic a-helical hairpin peptide
Barthe P, Cohen-Gonsaud M, Aldrian-Herrada G, Chavanieu A, Labesse G, Roumestand C, Comptes Rendus Chimie, 2004
(1)H, (15)N, and (13)C chemical shift assignments of the resuscitation promoting factor domain of Rv1009 from Mycobacterium tuberculosis
Cohen-Gonsaud M, Barthe P, Pommier F, Harris R, Driscoll PC, Keep NH, Roumestand C, J Biomol NMR, 2004
2003
Synthesis and NMR structure of p41icf, a potent inhibitor of human cathepsin L
Chiva C, Barthe P, Codina A, Gairi M, Molina F, Granier C, Pugniere M, Inui T, Nishio H, Nishiuchi Y, Kimura T, Sakakibara S, Albericio F, Giralt E, J. Am. Chem. Soc., 2003
Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes
Martin L, Stricher F, Misse D, Sironi F, Pugniere M, Barthe P, Prado-Gotor R, Freulon I, Magne X, Roumestand C, Menez A, Lusso P, Veas F, Vita C, Nat Biotechnol, 2003
1H, (15)N and (13)C chemical shift assignments of the Pleckstrin Homology domain of the Human Protein Kinase B (Pkb/Akt)
Auguin D, Barthe P, Auge-Senegas MT, Hoh F, Noguchi M, Roumestand C, J. Biomol. NMR, 2003
2002
Helix motion in protein C12A-p8(MTCP1): comparison of molecular dynamics simulations and multifield NMR relaxation data
Barthe P, Roumestand C, Demene H, Chiche L, J. Comput. Chem., 2002
Structure refinement of flexible proteins using dipolar couplings: application to the protein p8MTCP1
Demene H, Ducat T, Barthe P, Delsuc MA, Roumestand C, J. Biomol. NMR., 2002
2001
A comprehensive analysis of multifield 15N relaxation parameters in proteins: determination of 15N chemical shift anisotropies
Canet D, Barthe P, Mutzenhardt P, Roumestand C, J. Am. Chem. Soc., 2001
FIRE: predicting the spatial proximity of protein residues from 3D NOESY-HSQC
Malliavin T, Barthe P, Delsuc MA, Theor. Chem. Acc., 2001
Characterization of the folding and unfolding reactions of a small beta-barrel protein of novel topology, the MTCP1 oncogene product P13
Roumestand C, Boyer M, Guignard L, Barthe P, Royer CA, J. Mol. Biol., 2001
2000
Synthesis and NMR solution structure of an alpha-helical hairpin stapled with two disulfide bridges
Barthe P, Rochette S, Vita C, Roumestand C, Protein Sci., 2000
Engineering novel bioactive mini-proteins on natural scaffolds
Martin L, Barthe P, Combes O, Roumestand C, Vita C, Tetrahedron, 2000
1999
Refined solution structure and backbone dynamics of 15N-labeled C12A-p8MTCP1 studied by NMR relaxation
Barthe P, Chiche L, Declerck N, Delsuc MA, Lefevre JF, Malliavin T, Mispelter J, Stern MH, Lhoste JM, Roumestand C, J. Biomol. NMR., 1999
Backbone dynamics study of C12A-p8MTCP1 using the linear correlation approach at two magnetic field strengths. Effect of protein aggregation.
Barthe P, Declerck N, Delsuc MA, Lefevre JF, Roumestand C, J. Chim. Phys., 1999
Two well-defined motifs in the cAMP-dependent protein kinase inhibitor (PKIalpha) correlate with inhibitory and nuclear export function
Hauer JA, Barthe P, Taylor SS, Parello J, Padilla A, Protein Sci., 1999