Liste des publications

2022

• A flexible and original architecture of two unrelated zinc fingers underlies the role of the multitask P1 in RYMV spread

  Poignavent V, Hoh F, Terral G, Yang Y, Gillet FX, Kim JH, Allemand F, Lacombe E, Brugidou C, Cianferani S, Demene H, Vignols F, J Mol Biol, 2022

2021

• Molecular insights into the biased signaling mechanism of the mu-opioid receptor

  Cong X, Maurel D, Demene H, Vasiliauskaite-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R, Mol Cell, 2021

• Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex

  Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B, Sci Adv, 2021

• Resolving the activation mechanism of the D99N antiterminator LicT protein

  Yang Y, Gracy J, Declerck N, Demene H, J Struct Biol, 2021

2020

• NMR chemical shift assignment of a constitutively active fragment of the antitermination protein LicT

  Yang Y, Declerck N, Demene H, Biomol NMR Assign, 2020

• Structural Insights into of the Allosteric Activation of the LicT Antiterminator by PTS-Mediated Phosphorylation

  Yang Y, Padilla A, deGuillen K, Mammri L, Gracy J, Declerck N, Demene H, Structure, 2020

2019

• NMR chemical shift backbone assignment of the viral protein P1 encoded by the African Rice Yellow Mottle Virus

  Yang Y, Poignavent V, Gillet FX, Vignols F, Demene H, Biomol NMR Assign, 2019

2018

• Pathological interactions between mutant thyroid hormone receptors and corepressors and their modulation by a thyroid hormone analogue with therapeutic potential

  Harrus D, Demene H, Vasquez EF, Boulahtouf A, Germain P, Figueira AC, Privalsky ML, Bourguet W, le Maire A, Thyroid, 2018

2017

• PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo

  Aldrian G, Vaissiere A, Konate K, Seisel Q, Vives E, Fernandez F, Viguier V, Genevois C, Couillaud F, Demene H, Aggad D, Covinhes A, Barrere-Lemaire S, Deshayes S, Boisguerin P, J Control Release, 2017

• (1)H, (13)C and (15)N backbone chemical shift assignments of camelid single-domain antibodies against active state -opioid receptor

  Sounier R, Yang Y, Hagelberger J, Granier S, Demene H, Biomol NMR Assign, 2017

2016

• The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity

  Mas-Y-Mas S, Barbon M, Teyssier C, Demene H, Carvalho JE, Bird LE, Lebedev A, Fattori J, Schubert M, Dumas C, Bourguet W, Le Maire A, PLoS One, 2016

2015

• Propagation of conformational changes during mu-opioid receptor activation

  Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Demene H, Granier S, Nature, 2015

2013

• Equivalence between Euler angle conventions for the description of tensorial interactions in liquid NMR: application to different software programs

  Dosset P, Barthe P, Cohen-Gonsaud M, Roumestand C, Demene H, J Biomol NMR, 2013

2012

• Low concentration of a Gd-chelate increases the signal-to-noise ratio in fast pulsing BEST experiments.

  Sibille N, Bellot G, Wang J, Demene H, J. Magn. Reson., 2012

2011

• Expression, purification and NMR characterization of the cyclic recombinant form of the third intracellular loop of the vasopressin type 2 receptor

  Bellot G, Pascal R, Mendre C, Urbach S, Mouillac B, Demene H, Protein Expr Purif, 2011

2009

• Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR

  Bellot G, Granier S, Bourguet W, Seyer R, Rahmeh R, Mouillac B, Pascal R, Mendre C, Demene H, J Mol Biol, 2009

2008

• Structural mechanism of signal transduction between the RNA-binding domain and the phosphotransferase system regulation domain of the LicT antiterminator

  Demene H, Ducat T, DeGuillen K, Birck C, Aymerich S, Kochoyan M, Declerck N, J Biol Chem, 2008

• The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V2 receptor

  Granier S, Jean-Alphonse F, Bacqueville D, Monteil A, Pascal R, Poncet J, Guillon G, Boudier L, Arcemisbehere L, Mouillac B, Bellot G, Demene H, Mendre C, Regul Pept, 2008

2006

• Rapid determination of protein solubility and stability conditions for NMR studies using incomplete factorial design

  Ducat T, Declerck N, Gostan T, Kochoyan M, Demene H, J Biomol NMR, 2006

• Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs

  Granier S, Jean-Alphonse F, Demene H, Guillon G, Pascal R, Mendre C, Bioorg Med Chem Lett, 2006

2004

• A cyclic peptide mimicking the third intracellular loop of the V2 vasopressin receptor inhibits signaling through its interaction with receptor dimer and G protein

  Granier S, Terrillon S, Pascal R, Demene H, Bouvier M, Guillon G, Mendre C, J Biol Chem, 2004

2003

• Active peptidic mimics of the second intracellular loop of the V(1A) vasopressin receptor are structurally related to the second intracellular rhodopsin loop: a combined 1H NMR and biochemical study

  Demene H, Granier S, Muller D, Guillon G, Dufour MN, Delsuc MA, Hibert M, Pascal R, Mendre C, Biochemistry, 2003

2002

• Helix motion in protein C12A-p8(MTCP1): comparison of molecular dynamics simulations and multifield NMR relaxation data

  Barthe P, Roumestand C, Demene H, Chiche L, J. Comput. Chem., 2002

• Structure refinement of flexible proteins using dipolar couplings: application to the protein p8MTCP1

  Demene H, Ducat T, Barthe P, Delsuc MA, Roumestand C, J. Biomol. NMR., 2002

• 1H, 15N and 13C backbone resonance assignments of the 40 kDa LicT-CAT-PRD1 protein

  Ducat T, Declerck N, Kochoyan M, Demene H, J Biomol NMR, 2002

2001

• Translocation of the pAntp peptide and its amphipathic analogue AP-2AL

  Drin G, Demene H, Temsamani J, Brasseur R, Biochemistry, 2001

2000

• NMR Determination of the Magnetic Susceptibility Anisotropy of Cytochrome c' of Rhodobacter Capsulatus by 1JHN Dipolar Coupling Constants Measurement: Characterization of Its Monomeric State in Solution

  Demene H, Tsan P, Gans P, Marion D, J. Phys. Chem. B, 2000

1999

• Protein Conformation and Dynamics. Effects of Crankshaft Motions on 1H NMR Cross-Relaxation Effects

  Demene H, Sugar I, J. Phys. Chem. A, 1999

1998

• Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC)

  Demene H, Morellet N, Teilleux V, Huynh-Dinh T, de Rocquigny H, Fournie-Zaluski MC, Roques BP, J Mol Biol, 1998

• Structure par RMN de Vpr et des proteines de nucleocapside Ncp7 et Ncp10 et de leurs complexes avec les acides nucleiques : role biologique et inhibition.

  Roques B, Morellet N, Demene H, Jullian N, Schueler W, de Rocquigny H, Cahier IMABIO : Virologie structurale : defis et perspectives, 1998

1997

• Structure, biological functions and inhibition of the HIV-1 proteins Vpr and NCp7

  Roques BP, Morellet N, de Rocquigny H, Demene H, Schueler W, Jullian N, Biochimie, 1997

1994

• 1H NMR structure and biological studies of the His23-->Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity

  Demene H, Dong CZ, Ottmann M, Rouyez MC, Jullian N, Morellet N, Mely Y, Darlix JL, Fournie-Zaluski MC, Saragosti S, et al., Biochemistry, 1994

• Three-dimensional 1H NMR structure of the nucleocapsid protein NCp10 of Moloney murine leukemia virus

  Demene H, Jullian N, Morellet N, de Rocquigny H, Cornille F, Maigret B, Roques BP, J Biomol NMR, 1994

• Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR

  Morellet N, de Rocquigny H, Mely Y, Jullian N, Demene H, Ottmann M, Gerard D, Darlix JL, Fournie-Zaluski MC, Roques BP, J Mol Biol, 1994

1993

• Replacement of His23 by Cys in a zinc finger of HIV-1 NCp7 led to a change in 1H NMR-derived 3D structure and to a loss of biological activity

  Julian N, Demene H, Morellet N, Maigret B, Roques BP, FEBS Lett, 1993

• Influence of the N- and C-terminal chains on the zinc-binding and conformational properties of the central zinc-finger structure of Moloney murine leukaemia virus nucleocapsid protein: a steady-state and time-resolved fluorescence study

  Mely Y, de Rocquigny H, Piemont E, Demene H, Jullian N, Fournie-Zaluski MC, Roques B, Gerard D, Biochim Biophys Acta, 1993