Workshops

Quatrième Ecole Nationale RéNaFoBIS: école nationale de "Biologie Structurale Intégrative"

Organisée par RéNaFoBIS (Réseau National de Formation en Biologie Structurale Intégrative), du 16 au 23 Juin 2017 à l'Ile d'Oléron.

Site web : http://www.renafobis.fr

 

Deuxième Ecole Nationale RéNaFoBIS: école nationale de "Biologie Structurale Intégrative"

Organisée par RéNaFoBIS (Réseau National de Formation en Biologie Structurale Intégrative), du 20 au 27 mai 2016 à l'Ile d'Oléron.

Site web : http://www.renafobis.fr

Plaquette : fichier pdf

 

Biocampus: Atelier technologique "Les bases fondamentales de la cryo-microscopie"

Organisé par le plateau de microscopie électronique de la plateforme PIBS, les 27 et 28 Octobre 2015 au centre de biochimie structurale (CBS), Montpellier.

To download the talks, click this link : workshop slides

 

Biocampus: Atelier technologique "Biologie structurale : pour qui, pourquoi, comment"

Organisé par la plateforme PIBS, le 29 mai 2015 à l'amphithéatre de la délégation du CNRS, route de Mende.

To download the talks, click this link : workshop slides

 

 

Teaching

We are part of the teaching teams in the Master programs from the University of Montpellier.

For more information, please download the programs bellow.

 

 

 

flyerBioS2Master-Sciences-du-MAdicament-par-Parcours-Lg-13052015-1

 

Teams

Jobs

  • PHD position: Deciphering mechanism activity of potent biased agonists active in nephrogenic insipidus disease +

    Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

    We are seeking for a higly motivated candidate to postulate for a PhD position funded by the FRM through the "Fondation Line POMARET-DELALANDE, thesis funding on rare diseases".

    Thesis topic: Deciphering mechanism activity of potent biased agonists active in nephrogenic insipidus disease.

    G-protein Coupled Receptors (GPCRs) represent the largest class of eukaryotic cell surface receptors involved in signal transduction. The V2 vasopressin receptor (V2R) is a prototypal receptor for peptides, which governs water homeostasis in the body. Mutations of V2R are responsible for a rare genetic disease, the congenital Nephrogenic Diabetes Insipidus (cNDI), characterized by excessive urine voiding, dehydration, hypernatremia. We have characterized the very first biased ligands of V2R that rescue with long lasting effects V2R mutants responsible for NDI (Jean-Alfonse et al., J Am Soc Nephr 2009; Rahmeh et al., Proc Natl Acad Sci USA 2012).

    The thesis aims at structurally characterize the mode of action of biased ligands versus non-biased ligands using liquid NMR as principal tool (Sounier et al. 2015). The PhD student will be involved in the preparative biochemistry of V2R and NMR experiments design, recording and analysis. The results that will be generated from this work will pave the way to the design of more specific V2R ligands targeting NDI with fewer side effects and longer efficacy.

    The thesis work will be carried out in close collaboration between the two groups involved: Hélène Déméné, Centre de Biochime Structurale and Bernard Mouillac, Institut de Génomique Fonctionnelle, both in Montpellier (South of France). Both groups develop transverse unique cutting-edge methodologies (biophysics, pharmacology, biochemistry, molecular simulations) to decipher the structural bases of GPCR signaling.

    Selection criteria: Master students with a background in structural biology, especially in NMR, are encouraged to apply before July,12th 2018. The "Prix de Thèse sur les Maladies Rares" funded by Fondation Pomaret-Delalande-FRM is described here (dead line: August the 2nd, 2018)

    https://www.frm.org/upload/pdf/espace-chercheur/ao_prix_pomaret2018.pdf


    Net salary/month : 1400 euros, for three years.

    If you are interested, please contact This email address is being protected from spambots. You need JavaScript enabled to view it.

    Sounier R, Mas C, Steyaert J, Laeremans T Manglik A, Huang W, Kobilka BK, Déméné H*, Granier S (2015)(*co-corresp author) Nature 524(7565):375-8 285(9): 6337-47.
    Rahmeh R, Damian M, Cottet M, Orcel H, Mendre C, Durroux T, Sharma KS, Durand G, Pucci B, Trinquet E, Zwier JM, Deupi X, Bron P, Banères JL, Mouillac* B, Granier S (2012) (*co-corresp author) Proc Natl Acad Sci USA 109(17): 6733-38.
    Jean-Alphonse F, Perkovska S, Frantz MC, Durroux T, Méjean C, Morin D, Loison S, Bonnet D, Hibert M, Mouillac B, Mendre C. (2009) J Am Soc Nephrol. 20(10):2190-203.

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Frisbi

The French Infrastructure for Integrated Structural Biology (FRISBI) provides an infrastructure for integrative structural biology approaches, from the molecular to the cellular level, integrating multi-resolution data from X-ray crystallography, small angle X-ray scattering, NMR, Cryo-EM and functional data including development for protein expression and crystallization. FRISBI is open to structural and molecular and cell biologists from both academia and industry from France and Europe.

Connexion